Investigation of inflammatory bowel disease risk factors in 4 families in central China

Xu, Shuai; Zou, Hui; Zhang, Heng; Zhu, Siying; Zhou, Rui

doi:10.3892/etm.2017.5582

Cited by 7 publications

(7 citation statements)

References 45 publications

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“…However, these studies found that the common variants in NOD2/CARD15 found in Caucasians with CD are not associated with CD in the both Chinese Zhuang and Han population. Further analysis also revealed that CARD15 gene polymorphism was not associated UC in Chinese populations ( 38 , 39 ). Studies comparing IBD-related susceptibility genes between Chinese patients and Western patients might answer this question in the future.…”

Section: Resultsmentioning

confidence: 92%

A Systematic Review of Epidemiology and Risk Factors Associated With Chinese Inflammatory Bowel Disease

2018

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Background: Recent epidemiological data have revealed a dramatically rising prevalence and incidence of inflammatory bowel diseases (IBDs) in Mainland China, a rapidly growing industrialized region, over the last two decades.Objectives: We performed a systematic review to investigate the changing trends in the incidence of IBD in Mainland China and summarized the recent findings in risk factors associated with Chinese IBD.Methods: Relevant references were obtained from an electronic database search via MEDLINE and EMBASE (for English literatures), the China Academic Journals Full-text Database (CJFD) and the China Science Periodical Database (CSPD) in Wanfang Data (for Chinese literatures).Results: Total 1,584 abstracts in Chinese and 171 abstracts in English were collected. Eight full-text with epidemiological data, 25 with risk factor data in Chinese and 7 full-text with epidemiological data, 12 with risk factor data in English were finally identified and included for analysis. Data from included epidemiological studies has showed a striking increase in the incidence rate of IBD in Mainland China over time, and current incidence rates for IBD, UC, and CD were 1.80 (IBD), 1.33 (UC), and 0.46/1,000,000 (CD), though it varies among regions and ethnic minority populations. In addition, several risk factors including environmental factors, diet, intestinal infectious agents, hygiene, stress, and lifestyle have been reported to be associated with the increased incidence of Chinese IBD.Conclusion: This systematic review revealed an increased incidence of IBD in Mainland China. Although it is still lower than that in the Western world, however, China has a huge population; therefore, the total number of IBD patients might not be so little as previously thought and the disease burden of IBD in China is likely underestimated.HIGHLIGHTS Recent epidemiological data have revealed a dramatically rising prevalence and incidence of inflammatory bowel diseases (IBD) in Mainland China, a rapidly growing industrialized region, over the last two decades.This systematic review based on recent epidemiological data has revealed a striking increase in the incidence rate of IBD in Mainland China, though it varies among regions and ethnic minority populations.Several potential risk factors of IBD including environmental factors, diet, intestinal infectious agents, hygiene, stress, and lifestyle have been reported to be associated with the increased incidence of Chinese IBD.This systematic review on epidemiologic and risk factor studies has expanded understanding of the occurrence, distribution, geographic variance and risk factors of Chinese IBD and will provide clinicians important information in understanding current status of IBD in Mainland China.

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Section: Resultsmentioning

confidence: 92%

A Systematic Review of Epidemiology and Risk Factors Associated With Chinese Inflammatory Bowel Disease

2018

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“…A Chinese study reported family history describing the most commonly affected types of relatives were cousin (41.1%), sibling (37.5%), and parent (28.6%). 16 The explanation for different family history of IBD among different countries is possibly that families have different genetic backgrounds, and often different environments and lifestyles. Interestingly, maternal family history of IBD was found not significantly associated with IBD.…”

Section: Discussionmentioning

confidence: 99%

Consanguinity and Positive Family History of Inflammatory Bowel Diseases in Children: A Multicenter Case–Control Study

Hasosah

2022

Journal of Child Science

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Inflammatory bowel diseases (IBD), which comprise Crohn's disease (CD) and ulcerative colitis (UC), are rising trend in Saudi population. We aim to examine the association between consanguinity and family history and the risk of childhood IBD in Saudi children. A multicenter case–control study conducted in three tertiary hospitals in Jeddah and Riyadh, Saudi Arabia, during periods 2009 to 2021. Data about demographics, consanguinity, family history of IBD, and type of IBD were collected using a structured questionnaire. The same questionnaire was applied in matched case–control. Odds ratios (OR) and 95% confidence intervals (CI) were estimated using unconditional logistic regression analysis that was performed to compare both groups. The study population included 335 children: 167 IBD patients (49.9%) and 168 controls (50.1%). Of these IBD, 93 patients (56%) were CD and 74 patients (44%) were UC. Most of participants were females (72.1%) and their age more than 10 years (51.5%). There was first-degree consanguinity in 66 IBD patients (49.6%). No significant difference in first-degree consanguinity between cases and controls was noted (49.6% in cases vs. 50.4% in controls; OR = 1.02; 95% CI = 0.66–1.57). The consanguinity showed a more significant association with CD than UC (p < 0.05). Family history of IBD (father, siblings, and grandparents) as risk factors for IBD was identified: paternal history of IBD (OR = 0.25, 95% CI = 0.08–0.76), siblings' history of IBD (OR = 2.16, 95% CI = 1.92–2.43), and grandparent's history of IBD (OR = 0.22, 95% CI = 0.07–0.65). Family history of IBD showed a more significant association with CD than UC (p < 0.05). Consanguinity is strongly associated with IBD with more significant association with CD than UC and may possibly explain IBD rise in Saudi Arabia. The greatest risk of family history of IBD is in first-degree relatives, especially in siblings' rather than parents and grandparents.

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“…If the recipient’s lifestyle does not change to that of the donor after FMT, then the effect on the recipient’s microbial makeup may disappear over time. People living in different continents and regions have their own unique dietary habits[ 106 ]. The diet of Europeans is rich in cheese, butter and other high-fat and high-calorie foods, while the diet of Africans is low in calories and high in dietary fiber[ 107 ].…”

Section: Concomitant Lifestyle and Dietmentioning

confidence: 99%

Fecal microbiota transplantation in the metabolic diseases: Current status and perspectives

Ji¹,

Wen²,

Duan³

2022

WJG

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With the development of microbiology and metabolomics, the relationship between the intestinal microbiome and intestinal diseases has been revealed. Fecal microbiota transplantation (FMT), as a new treatment method, can affect the course of many chronic diseases such as metabolic syndrome, malignant tumor, autoimmune disease and nervous system disease. Although the mechanism of action of FMT is now well understood, there is some controversy in metabolic diseases, so its clinical application may be limited. Microflora transplantation is recommended by clinical medical guidelines and consensus for the treatment of recurrent or refractory Clostridium difficile infection, and has been gradually promoted for the treatment of other intestinal and extraintestinal diseases. However, the initial results are varied, suggesting that the heterogeneity of the donor stools may affect the efficacy of FMT. The success of FMT depends on the microbial diversity and composition of donor feces. Therefore, clinical trials may fail due to the selection of ineffective donors, and not to faulty indication selection for FMT. A new understanding is that FMT not only improves insulin sensitivity, but may also alter the natural course of type 1 diabetes by modulating autoimmunity. In this review, we focus on the main mechanisms and deficiencies of FMT, and explore the optimal design of FMT research, especially in the field of cardiometabolic diseases.

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Investigation of inflammatory bowel disease risk factors in 4 families in central China

Cited by 7 publications

References 45 publications

A Systematic Review of Epidemiology and Risk Factors Associated With Chinese Inflammatory Bowel Disease

A Systematic Review of Epidemiology and Risk Factors Associated With Chinese Inflammatory Bowel Disease

Consanguinity and Positive Family History of Inflammatory Bowel Diseases in Children: A Multicenter Case–Control Study

Fecal microbiota transplantation in the metabolic diseases: Current status and perspectives

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