Investigation of insulin resistance in the popularly used four rat models of type-2 diabetes

Chao, Pin-Chun; Li, Yingxiao; Chang, Chin-Hong; Shieh, Ja Ping; Cheng, Juei‐Tang; Cheng, Kai‐Chun

doi:10.1016/j.biopha.2018.02.084

Cited by 95 publications

(71 citation statements)

References 44 publications

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“…Second, we proved that blood glucose concentrations in fat-fed rats are not higher than values in chow-fed rats. This conclusion is consistent with previous reports that fasting glucose challenge insulin concentrations were signi cantly higher in high-fat rats, it appears likely that insulinmediated glucose disposal was decreased in these animals, which may lead to the lower blood glucose [21]. In Carvalho's study, compared with STZ mice fed with low-fat diet, STZ mice fed with HFD had lower blood glucose and higher body weight [22].…”

Section: Discussionsupporting

confidence: 90%

Study on optimization and stability of a single dose streptozotocin-induced diabetic modeling in rats

Zhang

Hong

et al. 2020

Preprint

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BackgroundOptimization of experimental conditions in streptozotocin induced diabetic model in Sprague Dawley (SD) rats to evaluate the stability of the model.MethodsMale and female SD rats were randomly divided into control group, STZ 45 group (STZ: 45 mg / kg), STZ 65 group (STZ: 65 mg / kg), STZ 85 group (STZ: 85 mg / kg), high fat diet with STZ 45 group (STZ: 45 mg / kg), high fat diet with STZ 65 group (STZ: 65 mg / kg), high fat diet with STZ 85 group (STZ: 85 mg / kg). N = 6 in each group. The changes of body weight and blood glucose were observed dynamically.ResultsThere was no significant difference in blood glucose or body weight between the STZ 45 group and the control group in both male and female rats, whether or not they were on a high-fat diet. However, there were significant differences in blood glucose between the high-dose STZ group and the control group in both male and female rats, regardless of whether the rats were on a high-fat diet or not (P < 0.05 or P < 0.01). Compared with the control group, there were significant differences in blood glucose levels (P < 0.05 or P < 0.01) and higher blood glucose levels in the male rats fed with the normal diet than that in those fed with the high-fat diet.ConclusionsIn this study, male rats fed with ordinary feed and injected STZ dose of 65 mg / kg were the most stable and ideal diabetic rat.

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Section: Discussionsupporting

confidence: 90%

Study on optimization and stability of a single dose streptozotocin-induced diabetic modeling in rats

Zhang

Hong

et al. 2020

Preprint

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“…injected with 55 mg of streptozotocin/kg body weight dissolved in citrate buffer (pH 4.5) after i.p. injection of 120 mg of nicotinamide/kg body weight dissolved in saline [13,14] level higher than 200 mg/dl after 48 h of streptozotocin/nicotinamide administration were considered as diabetic rats.…”

Section: Preparation Of Diabetic Ratsmentioning

confidence: 99%

Selenium decreases triglycerides and VLDL-c in diabetic rats exposed to electromagnetic radiation from mobile phone base stations

Ismaiil

Joumaa

Moustafa

2019

Journal of Taibah University for Science

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This study investigated the effects of exposure of diabetic rats to electromagnetic radiation (EMR) of 900 MHz from cell phone base stations antenna for four weeks on plasma triglycerides and cholesterol. We also examined whether selenium administration into these rats affects the levels of these parameters. Our results showed that the exposure of diabetic rats to this EMR increased the plasma triglycerides, total cholesterol and VLDL-c. The daily intraperitoneally injection of 2.0 μg selenium/kg body weight as sodium selenite into these rats decreased the triglycerides and VLDL-c levels compared to diabetic rats with EMR exposure. Selenium also restored the normal levels of plasma triglycerides, total cholesterol and HDL-c as compared to control rats. In conclusion, selenium decreased the elevated levels of triglycerides and cholesterol in diabetic rats exposed to EMR from cell phone base stations and hence it may decrease the development of some diabetic complications.

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“…Diabetes mellitus is a chronic metabolic disease, which has become a leading health concern worldwide. [1][2][3] The two types of diabetes are type 1 diabetes and type two diabetes (T2D), with much higher prevalence of T2D, which increases general multimorbidity posing social and economic burden. 4 T2D development is underlined by both genetic and environmental factors affecting energy balance and leading to a nexus of weight gain and insulin resistance (IR).…”

Section: Introductionmentioning

confidence: 99%

Low basal metabolic rate as a risk factor for development of insulin resistance and type 2 diabetes

Maciak

Sawicka

Sadowska

et al. 2020

BMJ Open Diab Res Care

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IntroductionIdentification of physiological factors influencing susceptibility to insulin resistance and type 2 diabetes (T2D) remains an important challenge for biology and medicine. Numerous studies reported energy expenditures as one of those components directly linked to T2D, with noticeable increase of basal metabolic rate (BMR) associated with the progression of insulin resistance. Conversely, the putative link between genetic, rather than phenotypic, determination of BMR and predisposition to development of T2D remains little studied. In particular, low BMR may constitute a considerable risk factor predisposing to development of T2D.Research design and methodsWe analyzed the development of insulin resistance and T2D in 20-week-old male laboratory mice originating from three independent genetic line types. Two of those lines were subjected to divergent, non-replicated selection towards high or low body mass-corrected BMR. The third line type was non-selected and consisted of randomly bred animals serving as an outgroup (reference) to the selected line types. To induce insulin resistance, mice were fed for 8 weeks with a high fat diet; the T2D was induced by injection with a single dose of streptozotocin and further promotion with high fat diet. As markers for insulin resistance and T2D advancement, we followed the changes in body mass, fasting blood glucose, insulin level, lipid profile and mTOR expression.ResultsWe found BMR-associated differentiation in standard diabetic indexes between studied metabolic lines. In particular, mice with low BMR were characterized by faster body mass gain, blood glucose gain and deterioration in lipid profile. In contrast, high BMR mice were characterized by markedly higher expression of the mTOR, which may be associated with much slower development of T2D.ConclusionsOur study suggests that genetically determined low BMR makeup involves metabolism-specific pathways increasing the risk of development of insulin resistance and T2D.

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Investigation of insulin resistance in the popularly used four rat models of type-2 diabetes

Cited by 95 publications

References 44 publications

Study on optimization and stability of a single dose streptozotocin-induced diabetic modeling in rats

Study on optimization and stability of a single dose streptozotocin-induced diabetic modeling in rats

Selenium decreases triglycerides and VLDL-c in diabetic rats exposed to electromagnetic radiation from mobile phone base stations

Low basal metabolic rate as a risk factor for development of insulin resistance and type 2 diabetes

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