The study of non-stationary flows featuring shock waves is motivated by the need to understand the physics of shock wave phenomena, as well as by the variety of applications in which shock waves appear spanning from engineering to astrophysics. In the case of shock (blast) wave propagation in an enclosure the interest stems from explosion dynamics which arises from the very sudden release of chemical, nuclear, electrical or mechanical energy in a limited space.Even though past studies have investigated instabilities occurring when two fluids of different densities are impulsively accelerated into each other by a shock wave, known as Richtmyer-Meshkov (or impulsive Rayleigh-Taylor) instability (6,18) , the investigation of flow instabilities arising from the interaction of blast waves with a solid structure has received scarce attention. Flow instabilities have been experimentally detected in the case of cylindrical blast waves (7,14) . Burrows and Fryxell (1992) (5) have also shown that instabilities can occur in the mantles of nascent neutron stars implying that the standard spherically symmetric models of neutron star birth and supernova explosion may be inadequate. The above findings follow earlier analytical work (4) regarding the formation of convective ABSTRACT The paper presents an investigation of flow instabilities occurring in shock-wave propagation and interaction with the walls of an enclosure. The shock-wave propagation is studied in connection with perturbed and unperturbed cylindrical blasts, initially placed in the centre of the enclosure, as well as for three different blast intensities corresponding to Mach numbers M s = 2, 5 and 10. The instability is manifested by a symmetry-breaking of the flow even for the case of an initially perfectly-symmetric blast. It is shown that the symmetry-breaking initiates around the centre of the enclosure as a result of the interaction of the shock waves reflected from the walls, with the low-density region in the centre of the explosion. The instability leads to fast attenuation of the shock waves, especially for smaller initial blast intensities. The computations reveal that the vortical flow structures arising from the multiple shock reflections and flow instability are Mach number dependent. The existence of perturbations of large amplitude in the initial condition strengthens the instability and has significant effects on the instantaneous wall pressure distributions. The computational investigation has been performed using high-resolution Riemann solvers for the gas dynamic equations.