Investigation of Irisin Level in Brucella Patients

Algül, Şermin; Şenol, Feray Ferda; Uğraş, Seda; Esmer, Fatih; Kara, Mehmet; Ekici, Pınar; Özçelik, Oğuz

doi:10.5505/ejm.2021.70431

Cited by 1 publication

(3 citation statements)

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“…patients compared to the control group (p<0.05) [18]. In our study, similar to the study conducted by Bu ¨yu ¨ktuna et al and Algu ¨l et al, we determined that irisin levels (9.27 ng/mL) were higher in patients with brucellosis compared to the control group (4.79, p<0.05).…”

Section: Plos Onesupporting

confidence: 90%

“…Although there are many studies examining the metabolic effects of irisin, there is little data evaluating its role in immunity. The majority of those studies report that irisin has anti-inflammatory effects [ 10 , 18 ]. Rizk et al investigated serum irisin levels in adults with metabolic syndrome, and they reported that irisin levels were high in patients with metabolic syndrome and elevated liver enzymes [ 19 ].…”

Section: Discussionmentioning

confidence: 99%

“…Büyüktuna et al found no correlation between irisin levels and disease severity or ALT levels [ 20 ]. Algül et al found higher irisin levels in brucella patients compared to the control group (p<0.05) [ 18 ]. In our study, similar to the study conducted by Büyüktuna et al and Algül et al, we determined that irisin levels (9.27 ng/mL) were higher in patients with brucellosis compared to the control group (4.79, p<0.05).…”

Section: Discussionmentioning

confidence: 99%

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Investigation of new inflammatory biomarkers in patients with brucella

Canpolat Erkan,

Tekin

2024

PLoS ONE

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Background Delayed diagnosis and inadequate treatment of infectious and inflammatory diseases, such as Brucella, lead to high rates of mortality and morbidity. The aim of our study was to investigate the association between serum levels of apelin, presepsin, and irisin with inflammation, laboratory parameters, and blood culture in patients with brucella. Patients and methods This prospective case-control study involves 30 patients with brucellosis and 30 healthy, matched control subjects. Thirty patients who were diagnosed with brucellosis were aged ≥ 18 years. Blood samples were taken from the patients on the first day they were diagnosed with brucellosis. The values of irisin, presepsin, and apelin were studied. In addition, blood samples were also taken from 30 healthy individuals for the control group. Irisin, presepsin, and apelin values that were measured in the patients on the first day were compared with those values measured in the control group. Results The sex and age statuses of the subjects are matched among the groups. The levels of irisin were significantly higher in patients with brucellosis compared to the control group (p<0.045). There was no significant difference between the two groups in terms of apelin and presepsin levels (p values 0.087 and 0.162, respectively). There was a positive correlation between irisin levels and elevated ALT levels, as well as positive blood cultures. Conclusions It appears that the measurement of irisin levels may be beneficial in patients with brucellosis. Irisin can be used as a diagnostic marker for brucella infection and may greatly clinicians to predict the severity disease and treatment response.

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Section: Plos Onesupporting

confidence: 90%