Investigation of iron’s neurotoxicity during cerebral maturation in the neonatal rat model of haemolysis

Akar, Ebru; Ünalp, Aycan; Dınız, Gülden; Ortaç, Ragıp; Senturk, Banu; Yılmaz, Osman; Kıray, Müge; Tepetam, Merve; Çöker, Canan; Cangar, Şükrü

doi:10.5114/fn.2015.54623

Cited by 6 publications

(2 citation statements)

References 25 publications

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“…Exposure to Fe is primarily through food consumption, although toxic levels of Fe accumulation are usually due to disrupted Fe homeostasis and metabolism in the brain 32 , 33 . Hemolysis, the breakdown of red blood cells, in the young brain with an immature blood-brain barrier (BBB) can also lead to aberrant Fe accumulation, which results in neuronal damages 34 . Fe accumulation can cause increased ROS levels, lipid peroxidation, protein oxidation, DNA damage, dopamine autoxidation, and mitochondrial fragmentation 35 – 38 .…”

Section: Essential Metalsmentioning

confidence: 99%

Metals and Neurodegeneration

2016

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Metals play important roles in the human body, maintaining cell structure and regulating gene expression, neurotransmission, and antioxidant response, to name a few. However, excessive metal accumulation in the nervous system may be toxic, inducing oxidative stress, disrupting mitochondrial function, and impairing the activity of numerous enzymes. Damage caused by metal accumulation may result in permanent injuries, including severe neurological disorders. Epidemiological and clinical studies have shown a strong correlation between aberrant metal exposure and a number of neurological diseases, including Alzheimer’s disease, amyotrophic lateral sclerosis, autism spectrum disorders, Guillain–Barré disease, Gulf War syndrome, Huntington’s disease, multiple sclerosis, Parkinson’s disease, and Wilson’s disease. Here, we briefly survey the literature relating to the role of metals in neurodegeneration.

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Section: Essential Metalsmentioning

confidence: 99%

Metals and Neurodegeneration

2016

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“…. Iron (Fe): Excess Fe deposition in a developing brain due to haemolysis may lead to immature blood brain barrier formation and neuron damage or neurodegeneration with brain iron accumulation (NBIA)[22][23].5. Manganese (Mn):6.…”

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confidence: 99%

A Review on Toxins Mediated Neuro Diseases and Ameliorative Role of Certain Phytochemicals

Gupta,

Pandey,

Singh

et al. 2023

J Pharmacol Clin Toxicol

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According to an estimate, about 6.8 million people die every year as a result of neurological disorders. These disorders arise due to degeneration of nerve cells and disrupt normal brain functions impacting personal and professional behaviour like cognition, retention and neurological functions. Though there are many reasons attributed to the emergence of neurodegenerative diseases like genetic, environmental, age, physiological processes etc. The free radicals are formed in the body as a normal product of aerobic metabolism, but it can also be formed due to increased exposure of environmental toxins like heavy metals (aluminium, arsenic, copper, iron, manganese, zinc, cadmium, lead), pesticides (organochlorines, organophosphates), and chronic inflammations or certain disease conditions. If the turnover of free radicals is not maintained, they ultimately lead to initiation of several diseases such as the hepatic, renal, cardiac, neurodegenerative disorders and many more. Brain cells completely depend on oxygen and glucose for energy requirement the increased free radicals may disrupt this process making the individual susceptible to diseases. In this review we have discussed an update of various aspects of neurodegenerative diseases arising due to environment neurotoxins, intrinsic factors, and their amelioration.

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Iron-mediated oxidative cell death is a potential contributor to neuronal dysfunction induced by neonatal hemolytic hyperbilirubinemia

Viktorínová

2018

Archives of Biochemistry and Biophysics

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Investigation of iron’s neurotoxicity during cerebral maturation in the neonatal rat model of haemolysis

Abstract: A b s t r a c t Introduction: Haemolytic disease of newborns due to rhesus and AB0 incompatibility is encountered frequently in neonatal clinics

Cited by 6 publications

References 25 publications

Metals and Neurodegeneration

Metals and Neurodegeneration

A Review on Toxins Mediated Neuro Diseases and Ameliorative Role of Certain Phytochemicals

Iron-mediated oxidative cell death is a potential contributor to neuronal dysfunction induced by neonatal hemolytic hyperbilirubinemia

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