Investigation of ischemia-modified albumin and thiol/disulfide homeostasis for the determination of oxidative stress in sheep with toxoplasmosis

Aydın, Ömer; Özkurt, Güzin; Çamkerken, İlker; Eren, Emre; Yanar, Kerim Emre; Aktaş, Mustafa Sinan

doi:10.1016/j.smallrumres.2023.107023

Small Ruminant Research

2023

DOI: 10.1016/j.smallrumres.2023.107023

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Investigation of ischemia-modified albumin and thiol/disulfide homeostasis for the determination of oxidative stress in sheep with toxoplasmosis

Ömer Aydın,

Güzin Özkurt,

İlker Çamkerken

et al.

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2024

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Cited by 3 publications

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Evaluation of pregnancy toxemia in goats: Metabolic profile, hormonal findings, and redox balance

Uzti̇mür,

Ünal

2024

Small Ruminant Research

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Evaluation of pregnancy toxemia in goats: Metabolic profile, hormonal findings, and redox balance

Uzti̇mür,

Ünal

2024

Small Ruminant Research

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Lipid peroxidation and thiol/disulfide homeostasis in cattle with trichophytosis

Bölükbaşı,

Merhan

2024

Dicle Üniv Vet Fak Derg

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The aim of this study was to determine thiol/disulfide homeostasis in cattle with trichophytosis and to determine the changes in malondialdehyde (MDA), catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase (GSH-Px=GPx) levels due to the disease. 15 cattle with trichophytosis and 15 healthy cattle in the control group constituted the material of the study. Blood samples were taken from the jugular vein of the animals in tubes with and without anticoagulant. MDA, CAT, SOD, total thiol, native thiol analyses were performed in serum and GSH-Px analyses were performed in plasma. It was determined that total thiol, native thiol and native thiol/total thiol levels among biochemical parameters in cattle with trichophytosis decreased statistically significantly. It was determined that disulfide/native thiol and disulfide/total thiol levels increased statistically compared to the control group. Although the disulfide level increased compared to the control group, it was not statistically significant. In addition, it was determined that MDA level increased compared to the control group, CAT, SOD and GSH-Px levels decreased statistically significantly compared to the control group. In conclusion, the findings obtained from the study showed that trichophytosis causes oxidative stress in cattle, and the use of oxidative stress markers, especially thiol/disulfide homeostasis markers, would contribute to the pathogenesis of trichophytosis.

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Determination of Thiol/Disulfide Homeostasis and Oxidative Stress Index in Sheeppox Virus

Adıgüzel,

Merhan

2024

Animal Health Production and Hygiene

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The aim of the study was to determine the thiol/disulfide homeostasis and oxidative stress parameter levels in sheep infected with pox virus and to investigate their diagnostic significance. 1-2 years old Morkaraman breed sheep (20 infected with pox virus, 10 healthy) were used in the study. Total thiol, native thiol, total antioxidant capacity (TAC) and total oxidant capacity (TOC) analyses were performed in sera obtained from blood samples taken from the jugular vein of the sheep in tubes without anticoagulant. When the pox virus infected group and healthy sheep were compared, it was determined that total thiol and native thiol levels were significantly decreased; disulfide, disulfide/native thiol and disulfide/total thiol levels increased but were not statistically significant. In addition, it was determined that serum TOC and oxidative stress index (OSI) levels increased, while TAC level decreased. In conclusion, the findings obtained in the study suggest that the disease causes oxidative stress, and the use of oxidative stress markers, especially thiol/disulfide homeostasis markers, may contribute to the pathogenesis of smallpox and be an auxiliary parameter for its diagnosis.

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Investigation of ischemia-modified albumin and thiol/disulfide homeostasis for the determination of oxidative stress in sheep with toxoplasmosis

Cited by 3 publications

References 43 publications

Evaluation of pregnancy toxemia in goats: Metabolic profile, hormonal findings, and redox balance

Evaluation of pregnancy toxemia in goats: Metabolic profile, hormonal findings, and redox balance

Lipid peroxidation and thiol/disulfide homeostasis in cattle with trichophytosis

Determination of Thiol/Disulfide Homeostasis and Oxidative Stress Index in Sheeppox Virus

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