Investigation of isoflavone constituents from tuber of Apios americana Medik and its protective effect against oxidative damage on RIN-m5F cells

Zhou, Weiying; Yang, Liangyuan; Deng, Ke; Xu, Guangzi; Wang, Yan; Ni, Qinxue; Zhang, Youzuo

doi:10.1016/j.foodchem.2022.134655

Cited by 6 publications

(5 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The consumption of foods enriched with active ingredients may potentially reduce oxidative damage and prevent chronic diseases, including obesity, hypertension, and diabetes 3 – 5 , 34 . Thus, this study focused on the anti-diabetic effect of mixed grains, with different blending ratios; our results showed that mixed grains are a good source of antioxidants.…”

Section: Resultsmentioning

confidence: 99%

Comparative study on the effects of grain blending on functional compound content and in vitro biological activity

Han,

Woo,

Lee

et al. 2024

Sci Rep

View full text Add to dashboard Cite

In this study, changes in bioactive compound contents and the in vitro biological activity of mixed grains, including oats, sorghum, finger millet, adzuki bean, and proso millet, with eight different blending ratios were investigated. The total phenolic compounds and flavonoid contents ranged from 14.43–16.53 mg gallic acid equivalent/g extract and 1.22–5.37 mg catechin equivalent/g extract, respectively, depending on the blending ratio. The DI-8 blend (30% oats, 30% sorghum, 15% finger millet, 15% adzuki bean, and 10% proso millet) exhibited relatively higher antioxidant and anti-diabetic effects than other blending samples. The levels of twelve amino acids and eight organic acids in the grain mixes were measured. Among the twenty metabolites, malonic acid, asparagine, oxalic acid, tartaric acid, and proline were identified as key metabolites across the blending samples. Moreover, the levels of lactic acid, oxalic acid, and malonic acid, which are positively correlated with α-glucosidase inhibition activity, were considerably higher in the DI-blending samples. The results of this study suggest that the DI-8 blend could be used as a functional ingredient as it has several bioactive compounds and biological activities, including anti-diabetic activity.

show abstract

Section: Resultsmentioning

confidence: 99%

Comparative study on the effects of grain blending on functional compound content and in vitro biological activity

Han,

Woo,

Lee

et al. 2024

Sci Rep

View full text Add to dashboard Cite

show abstract

“…In addition, our analysis found that NQO1 and NRF2 are involved in response to xenobiotic stimulus, fluid shear stress, and atherosclerosis pathways in cancer. Previous studies have shown that oxidative stress-related genes such as NQO1 are enriched in fluid shear stress and atherosclerotic pathways in a hydrogen peroxide-induced RIN-m5F cell injury model, suggesting that the NRF2 signaling pathway may play a protective role ( Zhou et al, 2023 ). However, our study also found that NQO1 may also be related to folate biosynthesis and response to the xenobiotic stimulus.…”

Section: Discussionmentioning

confidence: 99%

Pan-cancer and single-cell analysis reveal the prognostic value and immune response of NQO1

Shen,

Jiang,

Yang

et al. 2023

Front. Cell Dev. Biol.

View full text Add to dashboard Cite

Background: Overexpression of the NAD(P)H: Quinone Oxidoreductase 1 (NQOI) gene has been linked with tumor progression, aggressiveness, drug resistance, and poor patient prognosis. Most research has described the biological function of the NQO1 in certain types and limited samples, but a comprehensive understanding of the NQO1’s function and clinical importance at the pan-cancer level is scarce. More research is needed to understand the role of NQO1 in tumor infiltration, and immune checkpoint inhibitors in various cancers are needed.Methods: The NQO1 expression data for 33 types of pan-cancer and their association with the prognosis, pathologic stage, gender, immune cell infiltration, the tumor mutation burden, microsatellite instability, immune checkpoints, enrichment pathways, and the half-maximal inhibitory concentration (IC50) were downloaded from public databases.Results: Our findings indicate that the NQO1 gene was significantly upregulated in most cancer types. The Cox regression analysis showed that overexpression of the NQO1 gene was related to poor OS in Glioma, uveal melanoma, head and neck squamous cell carcinoma, kidney renal papillary cell carcinoma, and adrenocortical carcinoma. NQO1 mRNA expression positively correlated with infiltrating immune cells and checkpoint molecule levels. The single-cell analysis revealed a potential relationship between the NQO1 mRNA expression levels and the infiltration of immune cells and stromal cells in bladder urothelial carcinoma, invasive breast carcinoma, and colorectal cancer. Conversely, a negative association was noted between various drugs (17-AAG, Lapatinib, Trametinib, PD-0325901) and the NQO1 mRNA expression levels.Conclusion: NQO1 expression was significantly associated with prognosis, immune infiltrates, and drug resistance in multiple cancer types. The inhibition of the NQO1-dependent signaling pathways may provide a promising strategy for developing new cancer-targeted therapies.

show abstract

“…The content of MDA could accurately reflect the degree of lipid oxidation and cellular oxidative stress. The higher the content of MDA, the higher the degree of cellular oxidative stress and the higher the cellular oxidative damage caused [49]. Some endogenous antioxidant enzymes exist in the antioxidant system of cells, such as GSH-Px, SOD, and CAT, which could reduce cellular oxidative damage by controlling the dynamic balance of free radicals in the body.…”

Section: Protective Effect Of Glycosylated Proteins On Oxidative Dama...mentioning

confidence: 99%

Antioxidant Activity and Cell Protection of Glycosylated Products in Different Reducing Sugar Duck Liver Protein Systems

Zhan

Luo

Sun

et al. 2023

Foods

View full text Add to dashboard Cite

Duck liver is an important by-product of duck food. In this study, we investigated the effects of glucose, fructose, and xylose on the antioxidant properties of glycosylated products of duck liver protein and their protective effects on HepG2 cells. The results show that the glycosylation products of the three duck liver proteins (DLP-G, DLP-F, and DLP-X) all exhibit strong antioxidant activity; among three groups, DLP-X shows the strongest ability to scavenge DPPH, ·OH free radicals, and ABTS+ free radicals. The glycosylated products of duck liver protein are not toxic to HepG2 cells and significantly increase the activity of antioxidant enzymes such as SOD, CAT, and GSH-Px in HepG2 cells at the concentration of 2.0 g/L, reducing oxidative stress damage of cells (p < 0.05). DLP-X has a better effect in reducing oxidative damage and increasing cellular activity in HepG2 cells than DLP-G and DLP-F (p < 0.05). In this study, the duck liver protein glycosylated products by glucose, fructose, and xylose were named as DLP-G, DLP-F, and DLP-X, respectively.

show abstract

Investigation of isoflavone constituents from tuber of Apios americana Medik and its protective effect against oxidative damage on RIN-m5F cells

Cited by 6 publications

References 29 publications

Comparative study on the effects of grain blending on functional compound content and in vitro biological activity

Comparative study on the effects of grain blending on functional compound content and in vitro biological activity

Pan-cancer and single-cell analysis reveal the prognostic value and immune response of NQO1

Antioxidant Activity and Cell Protection of Glycosylated Products in Different Reducing Sugar Duck Liver Protein Systems

Contact Info

Product

Resources

About