Investigation of LFA-1 rs2230433 variation in renal cell carcinoma tissues

Pençe, Halime Hanım

doi:10.14744/hnhj.2019.63325

Haydarpasa Numune Med J

2019

DOI: 10.14744/hnhj.2019.63325

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Investigation of LFA-1 rs2230433 variation in renal cell carcinoma tissues

Halime Hanım Pençe¹

Abstract: Results: LFA-1 rs2230433 GC and CC genotypes were found similar between tumor and control groups (p>0.05). However, GG genotype was higher in tumors (8%) than controls (2%). Discussion and Conclusion:Our results showed that normal GG genotype is higher in tumors. Thus, GG genotype can be related to tumorigenic features.

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2024

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Population-enriched innate immune variants may identify candidate gene targets at the intersection of cancer and cardio-metabolic disease

Yeyeodu,

Hanafi,

Webb

et al. 2024

Front. Endocrinol.

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Both cancer and cardio-metabolic disease disparities exist among specific populations in the US. For example, African Americans experience the highest rates of breast and prostate cancer mortality and the highest incidence of obesity. Native and Hispanic Americans experience the highest rates of liver cancer mortality. At the same time, Pacific Islanders have the highest death rate attributed to type 2 diabetes (T2D), and Asian Americans experience the highest incidence of non-alcoholic fatty liver disease (NAFLD) and cancers induced by infectious agents. Notably, the pathologic progression of both cancer and cardio-metabolic diseases involves innate immunity and mechanisms of inflammation. Innate immunity in individuals is established through genetic inheritance and external stimuli to respond to environmental threats and stresses such as pathogen exposure. Further, individual genomes contain characteristic genetic markers associated with one or more geographic ancestries (ethnic groups), including protective innate immune genetic programming optimized for survival in their corresponding ancestral environment(s). This perspective explores evidence related to our working hypothesis that genetic variations in innate immune genes, particularly those that are commonly found but unevenly distributed between populations, are associated with disparities between populations in both cancer and cardio-metabolic diseases. Identifying conventional and unconventional innate immune genes that fit this profile may provide critical insights into the underlying mechanisms that connect these two families of complex diseases and offer novel targets for precision-based treatment of cancer and/or cardio-metabolic disease.

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Population-enriched innate immune variants may identify candidate gene targets at the intersection of cancer and cardio-metabolic disease

Yeyeodu,

Hanafi,

Webb

et al. 2024

Front. Endocrinol.

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show abstract

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Investigation of LFA-1 rs2230433 variation in renal cell carcinoma tissues

Cited by 1 publication

References 12 publications

Population-enriched innate immune variants may identify candidate gene targets at the intersection of cancer and cardio-metabolic disease

Population-enriched innate immune variants may identify candidate gene targets at the intersection of cancer and cardio-metabolic disease

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