Investigation of lipid peroxide and glutathione redox status of chicken conserning on high dietary selenium intake

Balogh, Krisztián; Kovács-Weber, Mária; Erdélyi, Márta; Mézes, Miklós

doi:10.1556/abiol.58.2007.3.3

Cited by 18 publications

(13 citation statements)

References 21 publications

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“…Activity of GPx, part of the antioxidant defence system, was not significantly lower in the other hybrids with lower weight gain, which result is partly in agreement with a previous research, which showed a negative correlation between weight gain and GPx activity in pig (Lingaas et al 1991). GPx activity in liver and kidney homogenates showed overall positive correlation with the GSH content, which was also found in our previous experiment with poultry (Balogh et al 2007). This positive correlation can be explained based on the previous data that GPx is an enzyme with allosteric activation property by its substrates (namely hydrogen-peroxide and other oxygen containing free radicals) and co-substrate (GSH) (Perona et al 1978).…”

Section: Discussionsupporting

confidence: 89%

Correlations between daily weight gain, lipid peroxidation and glutathione status of liver and kidney in different pig genotypes

et al. 2012

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Four pig hybrids (Pannon, Középtiszai and Dalland) were fattened up to 100±2 kg body weight. Feed intake and body weight were measured and daily weight gain was calculated. Malondialdehyde (MDA) and reduced glutathione (GSH) content, and glutathione peroxidase (GPx) activity were measured in liver and kidney. Daily weight gain was significantly lower in Pannon and Hungahib-39 hybrids. Amount of MDA was significantly higher in the liver of the hybrids with higher daily weight gain, and similar tendency was found in kidney. GSH content of liver did not differ significantly among the hybrids. The kidney of the Középtiszai hybrid had significantly lower GSH concentration than the others. GPx activity was the lowest in liver and kidney of Középtiszai hybrid. There was no significant correlation between daily weight gain and MDA content in liver, but positive correlation was found in the kidney of Pannon and Hungahib-39 hybrids. Daily weight gain showed significant correlation with GSH content of liver of Középtiszai hybrid. Between daily weight gain and GPx activity negative correlations were found in all hybrids and tissues, but none of them was significant. GSH content showed negative significant correlation with MDA content of liver of Középtiszai and in kidney of Pannon hybrid. Correlation between GSH content and GPx activity was positive and significant in the liver and kidney of Pannon hybrid. The results showed that different daily weight gain of pig hybrids has effect on the lipid peroxide and glutathione status of liver and kidney.

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Section: Discussionsupporting

confidence: 89%

Correlations between daily weight gain, lipid peroxidation and glutathione status of liver and kidney in different pig genotypes

et al. 2012

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“…Such observation has been made for example in erythrocytes, plasma, kidney and liver of rats fed with a diet containing 3, 6 and 10 mg/kg of Se as selenite or selenomethionine [198]. Other authors observed that excess Se in the diet (both organic and inorganic) was associated with the increased GPx activity in the liver of chicken and, importantly, these changes were accompanied by the toxic effects like increased lipid peroxidation and decreased cell viability [199]. Similar changes linked to the increased GPx activity accompanied by the increased lipid peroxidation have been observed in isolated fish hepatocytes, exposed to toxic dose of selenite [176].…”

Section: Biochemical Evidencementioning

confidence: 85%

Selenium and Human Health: Witnessing a Copernican Revolution?

Jabłońska

Vinceti

2015

Journal of Environmental Science and Health, Part C

140

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In humans, selenium was hypothesized to lower the risk of several chronic diseases, mainly due to the antioxidant activity of selenium-containing proteins. Recent epidemiologic and laboratory Downloaded by [New York University] at 16:24 19 June 2015 ACCEPTED MANUSCRIPT ACCEPTED MANUSCRIPT 2studies, however, are changing our perception of the biological effects of this nutritionally essential trace element. We reviewed the most recent epidemiologic and biochemical literature on selenium, synthesizing the findings from these studies into a unifying view. Randomized trials have shown that selenium did not protect against cancer and other chronic diseases, but even increased the risk of specific neoplasms such as advanced prostate cancer and skin cancer, in addition to type 2 diabetes. Biochemical studies indicate that selenium may exert a broad pattern of toxic effects at unexpectedly low concentrations. Furthermore, its upregulation of antioxidant proteins (selenium-dependent and selenium-independent) may be a manifestation of self-induced oxidative stress. In conclusion, toxic effects of selenium species occur at lower concentrations than previously believed. Those effects may include a large range of proteomic changes and adverse health effects in humans. Since the effects of environmental exposure to this element on human health still remain partially unknown, but are potentially serious, the toxicity of selenium exposure should be further investigated and considered as a public health priority.

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“…Reduced glutathione is also involved in the protection from oxidative stress in the infected lungs. GSH is the most important cellular antioxidant and plays a major role in protecting cells against oxidative stress [2]. It has been postulated that loss of GSH may eompromise the cellular antioxidant defense system and lead to accumulation of reactive oxygen species.…”

Section: Biochemical Studiesmentioning

confidence: 99%

Oxidative stress status in mouflons infected with lung worm Dictyocaulus viviparus

Nanev¹,

Gabrashanska²,

Vladov³

et al. 2011

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The purpose of our study is to examine the lung oxidative stress status in mouflons naturally infected with the nematode Dictyocaulus viviparus by determination of the malondyaldehyde (MDA) eoncentration as a biomarker of lipid peroxidation and its relation to the antioxidant status (glutathione, vitamin A, vitamin E, vitamin C, enzymes SOD, CAT, GPx and the trace elements selenium and zinc). 16 mouflons, non-infected and infected with D. v/vipafus were studied. Animals were shot in a hunt during the hunting season in ecological areas (naturally and anthropogenically non-polluted) in the Rhodope Mountains in Bulgaria. Antioxidant/oxidant imbalance occurred in the animals with dictyocaulosis. Levels of vitamin A, C and E, GSH and selenium were reduced, SOD, GPx and CAT activity was suppressed, whereas MDA level was increased in the lungs infected with D. viviparus compared to the non-infected. The zinc level was not ehanged in the infected animals. The results of the present study indicate that the antioxidant/oxidant imbalance was expressed mainly by significant reduction of the antioxidant enzyme activities. The present findings confirm that parasitic infection correlates well with OS status which can be assessed using enzymatic and nonenzymatic biomarkers. The pathogenesis of D. viviparus infection needs to be re-examined in order to understand more deeply the consequences of such an infection in the animal body.

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Investigation of lipid peroxide and glutathione redox status of chicken conserning on high dietary selenium intake

Cited by 18 publications

References 21 publications

Correlations between daily weight gain, lipid peroxidation and glutathione status of liver and kidney in different pig genotypes

Correlations between daily weight gain, lipid peroxidation and glutathione status of liver and kidney in different pig genotypes

Selenium and Human Health: Witnessing a Copernican Revolution?

Oxidative stress status in mouflons infected with lung worm Dictyocaulus viviparus

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