Investigation of &lt;i&gt;Toxoplasma gondii&lt;/i&gt; Seropositivity in Pregnant Women in Kastamonu Province, Turkey

Tüfekci, Enis Fuat; Yaşar-Duman, Melike; Çalışır, Büşra; Kilinc, Cetin; Uzel, Ahmet

doi:10.4274/tpd.galenos.2022.28247

Cited by 4 publications

(1 citation statement)

References 13 publications

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“…Toxoplasmosis is a common infection, is a protozoan parasite, Toxoplasma gondii infection is usually asymptomatic; however, people with low immunity will have serious neurological symptoms, but infection during pregnancy will cause serious clinical symptoms, and the risk of mother-to-child transmission of toxoplasmosis is greater than that of pre-pregnancy infection. Infection occurs through food or water contaminated with cat feces on the one hand, and through the use of undercooked, contaminated meat on the other [25,26] . At present, there are few studies on the relationship between raising pet cats during pregnancy and neonatal congenital heart disease.…”

Section: Discussionmentioning

confidence: 99%

Analysis of maternal factors affecting the occurrence of congenital heart disease in newborns in Lanzhou area and potency of a nomogram prediction model

Jiao,

Sun,

Jing

et al. 2023

Preprint

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Objective To analyze the maternal influencing factors of neonatal congenital heart defects (CHDs), to achieve the effect of prevention of neonatal CHDs. Methods A questionnaire survey was conducted on 134 newborns with CHDs from March 2022 to January 2023 as the case group, and 268 pregnant women were included in the control group according to the 1: 2 matching principle with age as the matching condition. Baseline data, pregnancy complications, and other clinical data of all subjects were collected. Logistic regression analysis was used to screen the risk factors affecting neonatal congenital heart disease. R software was used to construct a nomogram model for predicting the incidence of congenital heart disease. Results Logistic regression analysis showed that hypertensive disorder complicating pregnancy ( HDCP ) was a risk factor for CHDs ( OR = 3.77,95% CI : 2.18–6.53 ), gestational diabetes mellitus ( GDM ) was a risk factor for CHDs ( OR = 3.69,95% CI : 2.11–6.46 ), and keeping cats during pregnancy was a risk factor for CHDs ( OR = 2.73,95% CI : 1.02–7.34 ). The probability of GDM leading to congenital heart disease in offspring was 49.70%, the probability of HDCP leading to congenital heart disease in offspring was 48.60%, and the probability of raising cats during pregnancy leading to congenital heart disease in offspring was 38.00%.he probability of CHDs in offspring induced by HDCP and GDM was 78.70%, the probability of CHDs in offspring induced by HDCP and cats was 70.90%, the probability of CHDs in offspring induced by GDM and cats was 70.30%, and the probability of CHDs in offspring induced by HDCP, GDM, and cats was 90.50%. The nomogram predicts that the correction curve of the offspring CHDs model approaches the ideal curve. Conclusion We established a nomogram model of maternal influencing factors to predict the risk of congenital heart disease in neonates with good differentiation and consistency. This novel predictive model will help clinicians prevent congenital heart disease in offspring by improving maternal influencing factors.

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Section: Discussionmentioning

confidence: 99%

Analysis of maternal factors affecting the occurrence of congenital heart disease in newborns in Lanzhou area and potency of a nomogram prediction model

Jiao,

Sun,

Jing

et al. 2023

Preprint

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Genetic characterization of Toxoplasma gondii strains isolated from humans living in İzmir, Türkiye

Karakavuk,

Can,

Çeltik

et al. 2024

Indian Journal of Medical Microbiology

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Current status of TORCH infection Seroprevalence in pregnant women: a cross-sectional study in Al Sharqia Governorate, Egypt

et al. 2023

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Background TORCH infections during pregnancy significantly impact neonatal and maternal mortality rates worldwide. This study aimed to gather baseline serological data for pregnant women's immunological status to infection and determine if definite TORCH pathogens (cytomegalovirus, rubella virus, and Herpes simplex virus) were associated with Toxoplasma infection, to improve prenatal care and provide appropriate infection control strategies. Methodology Blood samples were gathered from 210 pregnant women attending Al Zagazig University hospitals from February to May 2023. Samples were examined for specific IgM and IgG antibodies against TORCH pathogens by electrochemiluminescence technique. Results Regarding TORCH infection, 60 (28.6%) cases were seronegative, while 77 (36.7%), 63 (30.0%), 56 (26.7%), and 15 (7.1%) were positive IgG antibodies against Toxoplasma gondii, cytomegalovirus, rubella virus, and Herpes simplex virus, respectively. There was no estimate for IgM for cytomegalovirus, rubella virus, or Herpes simplex virus, indicating that no primary infection had been detected during the pregnancy. There was a statistically significant association between seroprevalence of toxoplasmosis infections (IgM and IgG) and age group ≤ 25 years, which is the most common childbearing age group. Cytomegalovirus seropositivity was found in those beyond 25 years (P-value 0.001). Antibodies to mono-infections were found in 97/210 (46.2%) subjects. It is substantially higher under-25 years age group, 71/97 (73.2%), P-value of 0.001. 45/210 (21.4%) participants had antibodies to two agents, with no significant difference in the age group over 25 years, 26/45 (57.8%). Antibodies to three agents were assessed in eight instances, all under 25 years. Conclusions According to our findings, serological evaluation for the TORCH complex in all pregnant women is recommended to determine infection immunity, current immunization regimens, and infection reactivation. Low TORCH antibodies rates amongst pregnant women in Egypt's Sharqia governorate might be an appropriate starting point for prenatal screening initiatives.

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Investigation of <i>Toxoplasma gondii</i> Seropositivity in Pregnant Women in Kastamonu Province, Turkey

Cited by 4 publications

References 13 publications

Analysis of maternal factors affecting the occurrence of congenital heart disease in newborns in Lanzhou area and potency of a nomogram prediction model

Analysis of maternal factors affecting the occurrence of congenital heart disease in newborns in Lanzhou area and potency of a nomogram prediction model

Genetic characterization of Toxoplasma gondii strains isolated from humans living in İzmir, Türkiye

Current status of TORCH infection Seroprevalence in pregnant women: a cross-sectional study in Al Sharqia Governorate, Egypt

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