Investigation of Macular Structural and Microcirculatory Characteristics of Posterior Staphyloma in High Myopic Eyes by Swept Source Optical Coherence Tomography Angiography

Li, Haoru; Wang, Qingxin; Liu, Yucheng; Wang, Xin; He, Qichun; Chen, Yanhui; Wei, Ruihua

doi:10.3389/fphys.2022.856507

Cited by 7 publications

(7 citation statements)

References 39 publications

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“…PST was negatively correlated with optic disc tilt, PPA area, and optic disc vascular density (0–2 mm) and positively correlated with mean PST. Previous studies have revealed that subfoveal scleral thickness is negatively correlated with age and axial length, and positively correlated with subfoveal choroidal thickness [ 30 , 31 ]. We arrived at similar conclusions in the PST study.…”

Section: Discussionmentioning

confidence: 99%

Relationship between the structure and microcirculation of the optic disc region and myopic traction maculopathy in highly myopic eyes

Bai,

Sui,

et al. 2023

Graefes Arch Clin Exp Ophthalmol

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Purpose To explore the characteristics and influencing factors structural and microcirculatory of optic disc and peripapillary tissue in eyes with myopia traction maculopathy (MTM). Methods There were 100 eyes from 77 patients in this study. We used 1:1 matching axial length in myopic eyes. Patients were divided into two groups according to the presence or absence of MTM. Fundus structure parameters were obtained by swept source optical coherence tomography (SS-OCT), and the optic disc microcirculation parameters were obtained by OCT angiography (OCTA). Results MTM group were older (P = 0.001) and had poorer Best-corrected Visual Acuity (BCVA) (P = 0.011), the optic disc-fovea distance (DFD) was longer (P < 0.019), optic disc tilt was greater (P < 0.001), area of peripapillary atrophy (PPA) was larger (P < 0.001), and PPA/optical disc area (ONH) was higher (P < 0.001). The peripapillary scleral thickness (PST) was lower in the MTM group (P < 0.001). The mean peripapillary choroidal thickness (PCT) (P < 0.001) and PCT in the 10 orientations were significantly lower in the MTM group than in the NMTM group (all P < 0.01). Vascular density in the nasosuperior (NS) region of the optic disc was significantly lower in the MTM group (P = 0.037). The generalized estimating equation suggested that PPA area (P = 0.028), mean PCT (P = 0.008), superior PCT (P = 0.027), inferonasal PCT (P = 0.040), temporoinferior PCT (P = 0.013), and PST (P = 0.046) correlated with MTM. Age, axial length, optic disc tilt, PPA area, mean PCT, and optic disc central zone (0–2 mm) vascular density (all P < 0.05) were significantly correlated with PST. Conclusions The enlarged PPA area and thinner PCT and PST in eyes with MTM are more significant. Lower PST in high myopia was related to abnormalities of PCT and microcirculation. Trial registration Clinical Trial Registration number: ChiCTR2100046590

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Section: Discussionmentioning

confidence: 99%

Relationship between the structure and microcirculation of the optic disc region and myopic traction maculopathy in highly myopic eyes

Bai,

Sui,

et al. 2023

Graefes Arch Clin Exp Ophthalmol

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“…Owing to mechanical stretching caused by the limited bulge, subfoveal CT significantly decreased in the PS group [ 3 , 16 ]. However, our study showed that in adults with axial length ≥ 26 mm, a significant reduction was only observed in the superior thickness in the PS subgroup compared with that in group 1.…”

Section: Discussionmentioning

confidence: 99%

“…Thinning of the choroid in eyes with PS mainly appears in the small vascular layer, followed by the medium blood vessel [ 15 ]. The subfoveal and parafoveal choroidal capillary perfusion areas in eyes with PS are smaller than those in no posterior staphyloma eyes [ 16 ]. Moreover, these changes may be involved in the formation of neovascularization and myopic maculopathy in eyes with PS [ 17 , 18 ].…”

Section: Introductionmentioning

confidence: 99%

Effects of posterior staphyloma on choroidal structure in myopic adults: a retrospective study

Zhou,

Xiong,

Sun

et al. 2023

BMC Ophthalmol

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Background Studies on the choroid of myopic eyes with posterior staphyloma have shown that choroidal thickness decreased. This retrospective study further analysed the effects of posterior scleral staphyloma on choroidal blood vessels and matrix components compared to non-pathological myopia. Methods In this cross-sectional study, ninety-one eyes were divided into pathological (posterior staphyloma) and non-pathological myopia. The latter was further divided into three groups (Group 1: 26 mm ≤ axial length; Group 2: 24 mm ≤ axial length < 26 mm; Group 3: 22 mm ≤ axial length < 24 mm). Choroidal thickness, total choroidal area, luminal area, stromal area, and choroidal vascularity index were calculated. Results The CVI in N1, N2, I1, S2 of the posterior staphyloma group were lower than those of group 1 (both P < 0.05). The mean height of posterior staphyloma was associated with mean CT (Pearson correlation: r = -0.578, P = 0.039) but not with the mean CVI in posterior staphyloma group. In all groups, the mean choroidal thickness, total choroidal area, luminal area, and stromal area were significantly associated with axial length (P < 0.001), and the mean choroidal vascularity index was significantly associated with the mean choroidal thickness (P < 0.001). Conclusion The choroidal structure of pathological myopia with posterior staphyloma and non-pathological myopia with longer axial length demonstrates alterations in which choroidal vessels are more impaired than the stroma. A lower choroidal vascularity index should be alert to pathological changes for myopia with axial length > 26 mm.

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“…OCT and OCTA measurements were obtained about 1 h after cycloplegia to eliminate the potential confounding effects of accommodation on choroidal thickness and blood perfusion 13 . To minimise the potential confounding effects of diurnal variation, all measurements were conducted between 12:00 and 15:00 h. The SS‐OCT/OCTA system (VG200S; SVision Imaging, http://intalight.com) was used to assess the macular structures and vascular characteristics with high resolution and reproducibility 14,15 . The device was equipped with an SS laser and an eye‐tracking mechanism to eliminate eye movement artefacts.…”

Section: Methodsmentioning

confidence: 99%

“…com) was used to assess the macular structures and vascular characteristics with high resolution and reproducibility. 14,15 The device was equipped with an SS laser and an eye-tracking mechanism to eliminate eye movement artefacts. The central wavelength of the swept-source (SS) laser was 1050 nm (full width range, 990-1100 nm) with a scan rate of 200,000 A-scans per second.…”

Section: Swept-source Oct (Ss-oct)/octa Image Acquisitionmentioning

confidence: 99%

Retinal and choroidal structure and vascularity in Chinese emmetropic and myopic children

Liu,

Gou

et al. 2024

Ophthalmic Physiologic Optic

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PurposeThis study evaluated the structural features of the retinal and choroidal regions and their correlations with ocular biometric and vascular parameters in Chinese children using optical coherence tomography angiography (OCTA).MethodsA total of 159 children, 6–13 years of age, were included in this prospective study. The sample consisted of 55 emmetropes (spherical equivalent ≤ +0.75 and > −0.50 D), 53 low‐moderate myopes (≤ −0.50 to > −6.00 D) and 51 high myopes without pathological changes (≤ −6.00 D). Optical coherence biometry was used to measure axial length (AL) and anterior segment parameters. Swept‐source optical coherence tomography/OCTA was used to assess the macular structures and vascular characteristics in a 6 × 6 mm region centred on the macula.ResultsIn a comprehensive analysis adjusting for age, sex, AL, macular blood perfusion, intraocular pressure and anterior segment parameters, retinal thickness (RT) showed a significant positive association with deep retinal vascular density and superficial retinal vascular density in the foveal area, but not with AL. Moreover, RT exhibited a significant negative association with AL in the parafoveal and perifoveal regions. Further, a significant positive correlation was observed between choroidal thickness and both choroidal vascular volume and choriocapillaris perfusion area, along with a negative correlation with AL across the entire macular region.ConclusionsThis study showed that the thickness of retina and choroid in Chinese children was not only associated with AL but also showed dynamic properties such as the blood perfusion of the retina and choroid, particularly in the foveal area.

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Investigation of Macular Structural and Microcirculatory Characteristics of Posterior Staphyloma in High Myopic Eyes by Swept Source Optical Coherence Tomography Angiography

Cited by 7 publications

References 39 publications

Relationship between the structure and microcirculation of the optic disc region and myopic traction maculopathy in highly myopic eyes

Relationship between the structure and microcirculation of the optic disc region and myopic traction maculopathy in highly myopic eyes

Effects of posterior staphyloma on choroidal structure in myopic adults: a retrospective study

Retinal and choroidal structure and vascularity in Chinese emmetropic and myopic children

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