Investigation of mass-transfer in occluded rat arteryIn Vivo

Matveyev, M. Yu.; Borovikov, D. V.; Golubykh, V. L.; Domogatsky, S.P.

doi:10.1007/bf02499151

Cited by 1 publication

(1 citation statement)

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“…Convection ensures the transport of fibrinolytic components to the clot and their penetration into it. This is facilitated by pulse character of bloodstream, pressure gradient, blood viscosity and vascular wall elasticity [42]. Permeability of the clot facilitates the flow of liquids into it and formation of asymmetric channels.…”

Section: Internal Fibrinolysismentioning

confidence: 99%

Macromolecular Ensembles of Internal and External Fibrinolysis: the Resources for Enhancement of Thrombolysis Efficacy

Maksimenko

Tischenko²

2006

CMC

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The results of the search for new plasminogen activators for thrombolytic therapy have been reviewed with analysis of slowdown in this process. The reserves of increasing the effectiveness of thrombolysis are considered and the mechanisms underlying the interactions between plasminogen and its activators with fibrin are described. The domain composition of the fibrinolytic agents and the functional role of their structural elements in fibrinolytic interactions are discussed. The action of fibrin-specific and fibrin-nonspecific plasminogen activators in fibrinolysis has been evaluated. The necessity of the investigation of the regularities of internal and external fibrinolysis has been substantiated. The internal fibrinolysis became the resource for enhancement of thrombolysis efficacy. The approaches to the use of internal fibrinolysis to increase the effectiveness of enzyme therapy (monotherapy with plasminogen or new-made plasminogen activator as well as polytherapy with combination of different plasminogen activators /thrombolysis trigger plus third-generation plasminogen activator of prolonged action/) have been outlined and the relationship between this research and the current tendencies in the improvement of clinical thrombolysis (dose reduction, adjacent therapy, etc.) has been discussed.

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Section: Internal Fibrinolysismentioning

confidence: 99%