Investigation of mechanisms linking depressed mood to nicotine dependence

Lerman, Caryn; Audrain, Janet; Orleans, C. Tracy; Boyd, Richard; Gold, Karen; Main, David; Caporaso, Neil E.

doi:10.1016/0306-4603(95)00032-1

Cited by 201 publications

(176 citation statements)

References 34 publications

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“…Contrary to previous study findings which had reported a strong link between inattention symptoms and smoking, our data suggests that there is no significant relationship between ADHD-inattention scores and FNDT scores. In addition, Lerman et al (36) suggested that inattention scores were more likely to show a correlation with depressive symptoms; in addition, by emphasizing the high prevalence of smoking in depression, the authors hypothesized an independent mediating effect of depression is much more likely than that of smoking. In our study, comorbidity of depression was an exclusion criterion.…”

Section: Discussionmentioning

confidence: 99%

Attention-Deficit/Hyperactivity Disorder and Nicotine Dependence in Adults

Bilgi¹,

Aksoy

Onur

et al. 2017

Arch Neuropsychiatr

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Introduction: The aim of this study is to assess clinical characteristics and smoking profiles of individuals diagnosed with attention-deficit/ hyperactivity disorder (ADHD) and compare their nicotine dependence status with healthy controls for better understanding the mutual and complex relationship between ADHD and smoking. Methods:We included the following participants in the study: 40 adults with the diagnosis of ADHD, 40 participants who visited the smoking cessation polyclinic without any psychiatric disorders, and 40 healthy controls. A sociodemographic data form, Wender Utah Rating Scale (WURS), Adult ADD/ADHD Diagnosis and Evaluation Inventory, and Fagerstrom Nicotine Dependence Test (FNDT) were administered to the participants.Results: Mean age of the ADHD, nicotine dependence, and control groups was 28.68±7.22, 34.17±8.60, 33.70±7.45 years, respectively. Percentages of females and males were 27.5% and 72.5% in the ADHD group, 50% and 50% in the nicotine dependence group, 47.5% and 52.5% in the control group. The attention-deficit scores in the ADHD, nicotine dependence, and control groups were 21.18±5.05, 7.23±3.96, 4.75±2.65, respectively (p=0.001), whereas the hyperactivity scores were.73±5.84, 6.43±4.2, and 3.58±2.27, respectively (p=0.001). The related features scores were 56.53±12.96, 24.30±13.93, and 13.13±6.11, respectively (p=0.001), whereas the WURS scores were 61.88±12.69, 23.03±16.07, 11.90±8.15, respectively (p=0.001). FNDT scores in ADHD and nicotine dependence groups were 5.83±2.11 and 6.20±2.74, respectively (p=0.495).Conclusion: Considering the argument of ADHD being an independent risk factor for nicotine dependence, we think the co-occurrence of the smoking addiction and ADHD symptoms in the context of dopamine dysregulation is important in the clinical setting. Treatment modalities and of preventive strategies should be considered while keeping this in mind.

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Section: Discussionmentioning

confidence: 99%

Attention-Deficit/Hyperactivity Disorder and Nicotine Dependence in Adults

Bilgi¹,

Aksoy

Onur

et al. 2017

Arch Neuropsychiatr

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“…As previously reported, depression is also caused by nicotine (NC), an addictive substance in tobacco which alters the level of mood, as one of the most frequently observed psychiatric symptoms associated with its use (Lerman et al, 1996;Picciotto, 1998Picciotto, , 2002. Among the symptoms observed in depression, anhedonia, an affective symptom related to the inability to experience pleasure, has been regarded as a cardinal sign correlated with the severity of depression (Snaith, 1992).…”

Section: Introductionmentioning

confidence: 99%

Depression-related anhedonic behaviors caused by immobilization stress: a comparison with nicotine-induced depression-like behavioral alterations and effects of nicotine and/or "antidepressant" drugs

Hayase

2011

J. Toxicol. Sci.

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-Anhedonia, an affective symptom related to the inability to experience pleasure, is one of the representative symptoms observed in depression. In the present study, considering that repeated nicotine (NC) also causes "depressive" symptoms, the depression-related anhedonic behavioral alterations caused by a typical depression-inducing stressor, immobilization stress (IM), combined with or without NC administration, were examined in mice and compared with the depression-like behavioral alterations caused by NC. In the repeated IM (10 min, 4 days) group, as well as the repeated NC (0.3 mg/kg, s.c., 4 days) group, depression-related behavioral despair was observed in both forced swimming and tail suspension tests. Depression-related anhedonic behavioral alterations, as judged in the sucrose test, were observed only in the IM group. In the group treated with IM plus NC (IM-NC group), NC antagonized the IM-induced anhedonic attenuation of sucrose consumption in the sucrose test. Furthermore, in the IM-NC group, NC attenuated the effects of antidepressants which inhibit the reuptake of monoamines in the forced swimming test. Against the IM-induced anhedonia in the sucrose test, the cannabinoid agonists anandamide and CP 55940, in addition to the antidepressants previously reported, restored the preference for sucrose to control levels, with or without NC co-treatment. The absence of anhedonic behavioral alterations, the antidepressant-like anti-anhedonic effects against IM, and the effects against some antidepressant drugs all seemed to be characteristic of the effects of NC. Neural mechanisms other than those involved in the depression-like effects of NC seemed to contribute to the IM-induced anhedonic component of depression.

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“…is a characteristic of NC, as previously reviewed [4,5]. Depression is one of the most frequently-observed psychiatric symptoms associated with NC abuse, and has been reported mainly as a withdrawal symptom which occurs in dependent smokers [6,7]. Furthermore, in some daily smokers, direct depressant effects, which disappear soon after the cessation of smoking, have also been reported, and this is consistent with some animal experimental data [8-10].…”

Section: Introductionmentioning

confidence: 99%

Differential effects of TRPV1 receptor ligands against nicotine-induced depression-like behaviors

Hayase

2011

BMC Pharmacol

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BackgroundThe contributions of brain cannabinoid (CB) receptors, typically CB1 (CB type 1) receptors, to the behavioral effects of nicotine (NC) have been reported to involve brain transient receptor potential vanilloid 1 (TRPV1) receptors, and the activation of candidate endogenous TRPV1 ligands is expected to be therapeutically effective. In the present study, the effects of TRPV1 ligands with or without affinity for CB1 receptors were examined on NC-induced depression-like behavioral alterations in a mouse model in order to elucidate the "antidepressant-like" contributions of TRPV1 receptors against the NC-induced "depression" observed in various types of tobacco abuse.ResultsRepeated subcutaneous NC treatments (NC group: 0.3 mg/kg, 4 days), like repeated immobilization stress (IM) (IM group: 10 min, 4 days), caused depression-like behavioral alterations in both the forced swimming (reduced swimming behaviors) and the tail suspension (increased immobility times) tests, at the 2 h time point after the last treatment. In both NC and IM groups, the TRPV1 agonists capsaicin (CP) and olvanil (OL) administered intraperitoneally provided significant antidepressant-like attenuation against these behavioral alterations, whereas the TRPV1 antagonist capsazepine (CZ) did not attenuate any depression-like behaviors. Furthermore, the endogenous TRPV1-agonistic CB1 agonists anandamide (AEA) and N-arachidonyldopamine (NADA) did not have any antidepressant-like effects. Nevertheless, a synthetic "hybrid" agonist of CB1 and TRPV1 receptors, arvanil (AR), caused significant antidepressant-like effects. The antidepressant-like effects of CP and OL were antagonized by the TRPV1 antagonist CZ. However, the antidepressant-like effects of AR were not antagonized by either CZ or the CB1 antagonist AM 251 (AM).ConclusionsThe antidepressant-like effects of TRPV1 agonists shown in the present study suggest a characteristic involvement of TRPV1 receptors in NC-induced depression-like behaviors, similar to those caused by IM. The strong antidepressant-like effects of the potent TRPV1 plus CB1 agonist AR, which has been reported to cause part of its TRPV1-mimetic and cannabimimetic effects presumably via non-TRPV1 or non-CB1 mechanisms support a contribution from other sites of action which may play a therapeutically important role in the treatment of NC abuse.

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Investigation of mechanisms linking depressed mood to nicotine dependence

Cited by 201 publications

References 34 publications

Attention-Deficit/Hyperactivity Disorder and Nicotine Dependence in Adults

Attention-Deficit/Hyperactivity Disorder and Nicotine Dependence in Adults

Depression-related anhedonic behaviors caused by immobilization stress: a comparison with nicotine-induced depression-like behavioral alterations and effects of nicotine and/or "antidepressant" drugs

Differential effects of TRPV1 receptor ligands against nicotine-induced depression-like behaviors

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