Investigation of mechanisms of action of growth factors of autologous platelet-rich plasma used to treat erectile dysfunction

Epifanova, M.; Чалый, М. Е.; Krasnov, A O

doi:10.18565/urology.2017.4.46-48

Cited by 29 publications

(7 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“… 43 , 47 In an animal model of cavernous nerve injury, the administration of PRP growth factors resulted in a reduction in cellular apoptotic markers, reduced tissue fibrosis, neuronal regeneration, and an improvement in EF. 44 , 48 – 50 Several phase I–II human PRP clinical trials have shown promising data with good short-term safety. 17 , 50 In a mixed cohort of patients and different etiologies and reasons for PRP injections, Matz et al 17 reported that the IIEF scores improved by an average of 4.14 points in 5 patients who received PRP therapy with no serious adverse event.…”

Section: Resultsmentioning

confidence: 99%

“… 44 , 48 – 50 Several phase I–II human PRP clinical trials have shown promising data with good short-term safety. 17 , 50 In a mixed cohort of patients and different etiologies and reasons for PRP injections, Matz et al 17 reported that the IIEF scores improved by an average of 4.14 points in 5 patients who received PRP therapy with no serious adverse event.…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Regenerative technology to restore and preserve erectile function in men following prostate cancer treatment: evidence for penile rehabilitation in the context of prostate cancer survivorship

Chung

2021

Therapeutic Advances in Urology

View full text Add to dashboard Cite

Introduction: Erectile dysfunction (ED) following prostate cancer treatment is not uncommon and penile rehabilitation is considered the standard of care in prostate cancer survivorship (PCS), where both patient and his partner desire to maintain and/or recover pre-treatment erectile function (EF). There is a clinical interest in the role of regenerative therapy to restore EF, since existing ED treatments do not always achieve adequate results. Aim: To review regenerative therapies for the treatment of ED in the context of PCS. Materials and Methods: A review of the existing PubMed literature on low-intensity extracorporeal shockwave therapy (LIESWT), stem cell therapy (SCT), platelet-rich plasma (PRP), gene therapy, and nerve graft/neurorrhaphy in the treatment of ED and penile rehabilitation, was undertaken. Results: IESWT promotes neovascularization and neuroprotection in men with ED. While several systematic reviews and meta-analyses showed positive benefits, there is limited published clinical data in men following radical prostatectomy. Cellular-based technology such as SCT and PRP promotes cellular proliferation and the secretion of various growth factors to repair damaged tissues, especially in preclinical studies. However, longer-term clinical outcomes and concerns regarding bioethical and regulatory frameworks need to be addressed. Data on gene therapy in post-prostatectomy ED men are lacking; further clinical studies are required to investigate the optimal use of growth factors and the safest vector delivery system. Conceptually interpositional cavernous nerve grafting and penile re-innervation technique using a somatic-to-autonomic neurorrhaphy are attractive, but issues relating to surgical technique and potential for neural ‘regeneration’ are questionable. Conclusion: In contrast to the existing treatment regime, regenerative ED technology aspires to promote endothelial revascularization and neuro-regeneration. Nevertheless, there remain considerable issues related to these regenerative technologies and techniques, with limited data on longer-term efficacy and safety records. Further research is necessary to define the role of these alternative therapies in the treatment of ED in the context of penile rehabilitation and PCS.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Regenerative technology to restore and preserve erectile function in men following prostate cancer treatment: evidence for penile rehabilitation in the context of prostate cancer survivorship

Chung

2021

Therapeutic Advances in Urology

View full text Add to dashboard Cite

show abstract

“…The largest clinical study evaluating the efficacy of PRP in ED was performed in 75 patients with heterogeneous severities of ED (IIEF range 0–17). 71 Patients were randomized to receive either activated PRP (addition of calcium chloride to promote α–granule degranulation, n = 30), activated PRP plus oral PDE-5 inhibitor (n = 30), or non-activated PRP (without calcium chloride, n = 15). Autologous PRP was obtained by 2-step centrifugation of 72 mL of autologous blood for maximum platelet concentrations up to 2,400 k/µL and administered in 4 mL injections to each corpus cavernosum.…”

Section: Platelet-rich Plasma (Prp)mentioning

confidence: 99%

Restorative Therapies for Erectile Dysfunction: Position Statement From the Sexual Medicine Society of North America (SMSNA)

et al. 2021

View full text Add to dashboard Cite

Introduction: Current non-invasive treatments for erectile dysfunction (ED) include oral medications, intracavernosal injections, and vacuum-assisted devices. Though these therapies work well for many, a subset of patients have contraindications or are unsatisfied with these options. Restorative therapies for ED are a new frontier of treatments focused on regenerating diseased tissue and providing a potential "cure" for ED. Aim: The aim of this position statement is to examine existing clinical trial data for restorative therapies and identify elements that require further research before widespread adoption. Methods: A literature review was performed to identify all clinical trials performed with regenerative therapy for ED. This includes treatments such as stem cell therapy (SCT), platelet rich plasma (PRP), and restorative related technologies like low-intensity shockwave therapy (LiSWT). Main Outcome Measures: Most clinical trials in restorative therapies were assessed for safety, feasibility, or efficacy. This included recording adverse events, changes in sexual function and erectile function questionnaires, and diagnostics measures. Results: To date there is an absence of robust clinical data supporting the efficacy of restorative therapies regarding ED, though technologies such as LiSWT have established relative safety. Conclusions: Restorative therapies are a promising technology that represents a new frontier of treatment geared towards reversing disease pathology rather than just treating symptoms. However, current published clinical studies are limited. Future work needs to be adequately powered, multi-center, randomized, sham/ placebo-controlled trials in well-characterized patient populations to ensure safety and demonstrate efficacy. Until these studies are done, restorative therapies should be reserved for clinical trials and not offered in routine clinical practice. Liu JL, Chu KY, Gabrielson AT, et al. Restorative Therapies for Erectile Dysfunction: Position Statement From the Sexual Medicine Society of North America (SMSNA).

show abstract

“…Apart from conventionally employed CaCl 2 , the cold shock treatment to PRP in the presence of anticoagulant and chitosan may increase the stable release of PRP-contained growth factors [104]. A clinical study revealed that autologous PRP may recover erectile function through the release of its active biomaterials, such as PDGF-AA, PDGF-BB, VEGF, VEGF-D, FGF, and FGF-acid, the concentration of which could be enhanced by freezing/thawing [125]. This may be attributed to endogenous NO enhanced VEGF synthesis, which supports endothelial regeneration via angiogenesis [126].…”

Section: Clinical Efficacy Of Prp In Edmentioning

confidence: 99%

Revisiting the Regenerative Therapeutic Advances Towards Erectile Dysfunction

Liu

Chang

Wang³

et al. 2020

Cells

View full text Add to dashboard Cite

Erectile dysfunction (ED) is an inability to attain or maintain adequate penile erection for successful vaginal intercourse, leading to sexual and relationship dissatisfaction. To combat ED, various surgical and non-surgical approaches have been developed in the past to restore erectile functions. These therapeutic interventions exhibit significant impact in providing relief to patients; however, due to their associated adverse effects and lack of long-term efficacy, newer modalities such as regenerative therapeutics have gained attention due to their safe and prolonged efficacy. Stem cells and platelet-derived biomaterials contained in platelet-rich plasma (PRP) are thriving as some of the major therapeutic regenerative agents. In recent years, various preclinical and clinical studies have evaluated the individual, as well as combined of stem cells and PRP to restore erectile function. Being rich in growth factors, chemokines, and angiogenic factors, both stem cells and PRP play a crucial role in regenerating nerve cells, myelination of axons, homing and migration of progenitor cells, and anti-fibrosis and anti-apoptosis of damaged cavernous nerve in corporal tissues. Further, platelet-derived biomaterials have been proven to be a biological supplement for enhancing the proliferative and differentiation potential of stem cells towards neurogenic fate. Therefore, this article comprehensively analyzes the progresses of these regenerative therapies for ED.

show abstract

Investigation of mechanisms of action of growth factors of autologous platelet-rich plasma used to treat erectile dysfunction

Cited by 29 publications

References 0 publications

Regenerative technology to restore and preserve erectile function in men following prostate cancer treatment: evidence for penile rehabilitation in the context of prostate cancer survivorship

Regenerative technology to restore and preserve erectile function in men following prostate cancer treatment: evidence for penile rehabilitation in the context of prostate cancer survivorship

Restorative Therapies for Erectile Dysfunction: Position Statement From the Sexual Medicine Society of North America (SMSNA)

Revisiting the Regenerative Therapeutic Advances Towards Erectile Dysfunction

Contact Info

Product

Resources

About