Investigation of Melissa officinalis L. Essential Oil for Antifungal Activity against Cladosporium carrionii

Menezes, Camilla Pinheiro de; Guerra, Felipe Queiroga Sarmento; Pinheiro, Lílian Sousa; Trajano, Vinícius Nogueira; Pereira, Fillipe de Oliveira; Souza, Valmir Gomes De; Souza, Fábio Santos de; Lima, Edeltrudes de Oliveira

doi:10.9734/ijtdh/2015/17841

Cited by 10 publications

(5 citation statements)

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“…This leads in some case to a huge difference between chemotype of the same plants collected in different areas or different period of time during the same day or during different maturity stages. This has been reported for Allium sativum [24][25][26] and for Lavandula angustifolia [14,[27][28][29][30] and Melissa officinalis [4,12,13,16,[31][32][33][34][35][36]].…”

Section: Biosynthesis Of Terpenoidssupporting

confidence: 57%

Essential Oil’s Chemical Composition and Pharmacological Properties

Fokou¹,

Dongmo²,

Boyom³

2020

Essential Oils - Oils of Nature

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Essential oil, sent by nature, is a complex mixture of volatile secondary metabolites. Its composition varies along with many parameters that can lead to misunderstanding of its wonderful pharmacological property. In fact, from postharvest treatment to the compound's identification through extraction approaches, the original chemotype of essential oils can be misdescribed. The pharmacological potentials of these oils are well known in the traditional system since time immemorial. Nowadays, some chemotypes of these oils had shown the effect against WHO's top 10 killer diseases. But the misuses of these essential oils are in part due to the lack of robust and easy analysis strategy that can allow the quality of the essential oils.

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Section: Biosynthesis Of Terpenoidssupporting

confidence: 57%

Essential Oil’s Chemical Composition and Pharmacological Properties

Fokou¹,

Dongmo²,

Boyom³

2020

Essential Oils - Oils of Nature

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“…In previous studies, it was observed that Melissa officinalis essential oil (at 256 µg/mL) has antifungal activity, inhibiting the mycelial growth and conidial germination of C. carrionii [24]. M. officinalis essential oil is characterized by monoterpene compounds and citral is the principal component present [25].…”

Section: Resultsmentioning

confidence: 99%

Evaluation of the antifungal activity and mode of action of citral against Cladophialophora carrionii.

Menezes

Perez

Sousa

et al. 2023

Rev. Colomb. Cienc. Quím. Farm.

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Introduction: Cladophialophora carrionii is one of the most frequent etiologic agents of human chromoblastomycosis, a chronic cutaneous disease. Such fungal infections are difficult to treat and underlines the need for new antifungal agents. Citral is a monoterpene with known pharmacological properties, including antimi-crobial activity. Aims: To investigate the antifungal activity of citral against strains of C. carrionii. Methodology: The minimum inhibitory concentration (MIC) and the minimum fungicidal concentration (MFC) were determined by broth microdilution techniques. Citral was tested to evaluate its effects on C. carrionii mycelia growth and germination of fungal conidia. Next, it was investigated the possible citral action on cell walls (sorbitol assay) and cell membranes (ergosterol binding assay). Results: The MIC50 and MFC50 of citral were respectively 128 μg/mL and 512 μg/mL. The study shows that citral displayed in vitro antifungal potential against strains of C. carrionii, where it was capable of inhibiting both its mycelial growth and germination of conidia for this fungus, whilst affecting the structure of fungal cell membranes. Citral’s mechanism of action involves binding to ergosterol. Further study is needed to completely describe its effects before clinical use as a therapeutic antifungal agent.

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“…The same limitations apply to the evaluation of fungal growth inhibition by essential oils. The test methodology and the type of essential oils used have a great influence on the result [29]. Note that although standard antifungal susceptibility tests are currently available, information from in vitro studies is limited as it only provides a static measure of antimicrobial activity in a specific medium.…”

Section: Discussionmentioning

confidence: 99%