Investigation of microemulsion system for transdermal delivery of ligustrazine phosphate

Abstract

Ligustrazine phosphate is commonly used as an efficient drug to treat a variety of cardiovascular disorders with frequent administration for a short biological half-life. The purpose of the present study was to investigate a microemulsion system for transdermal delivery of ligustrazine phosphate for the convenient, efficient and safe administration. The existence regions of microemulsions containing isopropyl myristate, labrasol, plurol oleique ® and water were investigated in pseudo-ternary phase diagrams, according to which microemulsion vehicles were prepared to observe average diameter, pH value, stability and evaluate respective effect of each component on percutaneous delivery in vitro. The prepared microemulsions had average diameters ranging from 32.1 to 108.7 nm, mild pH values and suitable stability. The optimized microemulsion with permeation flux of 41.01 g/cm 2 /h across rat skin in vitro, showed no obvious irritation on back skin of rabbits. The results indicated that the studied microemulsion system might be a promising vehicle for transdermal delivery of ligustrazine phosphate.

Design and optimization of self-nanoemulsifying drug delivery systems of simvastatin aiming dissolution enhancement

“…However, increasing HLBmix above the value of 10 with ternary formulae P6 and P7 containing Lauroglycol TM FCC (oil), cause a slight increase in the z-average diameter. The decrease in droplet size may be the result of more surfactant being available for adsorption and the formation of a more closely packed surfactant film at the oil-water interface, thereby providing stable and condense interfacial film (Zhao et al, 2010;Gupta et al, 2011), as well as the decrease interfacial tension in the system, both of which in favor of the formation of nanoemulsions with smaller droplet size (Wang et al, 2009;Cui et al, 2011). This decrease in droplet size could be also attributed to the decrease in co-surfactant concentration with subsequent decrease in the expansion of the interfacial film supported by the presence of cosurfactant (Gao et al, 1998).…”

CaCO3-based carriers with prolonged release properties for antifungal drug delivery to hair follicles

“…[18][19][20][21] A number of them were designed for topical application for potentiating the absorption of the active moieties into various skin layers, thus providing improved local bioavailability. 22 Thus, the use of various vehicles with supramolecular structure (micelles, 23 dendrimers 24 ), vesicular carriers (including liposomes, 25,26 ethosomes, 27 and niosomes 28 ), emulsion systems, 29,30 solid, 31,32 or polymeric 33 particles was recently demonstrated to be beneficial in the treatment of fungal skin infections. 13,34,35 The speed and depth of the carrier penetration into the skin can differ depending on its nature.…”

Transdermal delivery of kojic acid from microemulgel

“…1996), employing vesicular drug delivery systems (El Maghraby et al, 2001;Ntimenou et al, 2012) delivering hydrophilic drugs using microneedles (Oh et al, 2008) or augmenting transdermal flux using laser systems (Gómez et al, 2008;Lee at al., 2001). Microemulsion provides another promising alternative for transdermal delivery for hydrophilic drugs (Cui et al, 2011;Hosmer et al, 2009;Kreilgaard et al, 2000;Zhang and MichniakKohn, 2011).…”