Investigation of Microplastics in Digestion System: Effect on Surface Microstructures and Probiotics

Chen, Hui; Chen, Hongmei; Nan, Shugang; Liu, Huan; Chen, Ling

doi:10.1007/s00128-022-03571-x

Cited by 8 publications

(2 citation statements)

References 59 publications

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“…The fluorescence intensities of all three samples (Cy5.5-COOH, Cy-PP (approximately 5 µm), and Cy-PP (10-50 µm)) were maintained over 95% for 10 min of exposure. Furthermore, in vitro digestion process simulation was performed before in vivo biodistribution study to prove the stability of Cy-PP microplastics in the body [41]. The simulated digestion consisted of three solutions: salivary, gastric, and intestinal fluids (SF, GF, and IF, respectively).…”

Section: In Vitro Stability Studymentioning

confidence: 99%

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Toxicity and Biodistribution of Fragmented Polypropylene Microplastics in ICR Mice

Lee

Kim

Kang

et al. 2023

IJMS

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Currently, polypropylene (PP) is used in various products, thus leading to high daily exposure in humans. Thus, it is necessary to evaluate the toxicological effects, biodistribution, and accumulation of PP microplastics in the human body. In this study, administration of two particle sizes of PP microplastics (approximately 5 and 10–50 µm) did not lead to any significant changes in several toxicological evaluation parameters, including body weight and pathological examination, compared with the control group in ICR mice. Therefore, the approximate lethal dose and no-observed-adverse-effect level of PP microplastics in ICR mice were established as ≥2000 mg/kg. Furthermore, we manufactured cyanine 5.5 carboxylic acid (Cy5.5-COOH)-labeled fragmented PP microplastics to monitor real-time in vivo biodistribution. After oral administration of the Cy5.5-COOH-labeled microplastics to the mice, most of the PP microplastics were detected in the gastrointestinal tract and observed to be out of the body after 24 h in IVIS Spectrum CT. Therefore, this study provides a new insight into the short-term toxicity, distribution, and accumulation of PP microplastics in mammals.

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Section: In Vitro Stability Studymentioning

confidence: 99%

“…Cyanine 5.5 carboxylic acid (Cy5.5-COOH) was purchased from Lumiprobe Ltd. (Wan Chai, Hong Kong). For the stability test with the digestive system, three kinds of simulated solutions, salivary, gastric, and intestinal fluids (SF, GF, and IF) were prepared using a previously described method [41].…”

Section: Materials and Reagentmentioning

confidence: 99%

Toxicity and Biodistribution of Fragmented Polypropylene Microplastics in ICR Mice

Lee

Kim

Kang

et al. 2023

IJMS

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Toxicological impacts of microplastics on human health: a bibliometric analysis

Mittal,

Tiwari,

Singh

et al. 2023

Environ Sci Pollut Res

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Plastic has been known as an arti cial polymer whereas environmental microplastics become a global concern. Microplastics are reported to cause immunotoxicity in human through gut deposition and entering the bloodstream. This study is a comprehensive indication of the recent research on microplastics toxicity in the gastrointestinal system. We performed bibliographic analysis using VOS viewer software, and analyzed the data received on microplastics and their impact on gut health which has grown exponentially since 2016. Recent ndings also support the microplastic toxicity in combination with heavy metals. The smaller particle size and other factors enhanced the adsorption ability of environmental contamination such as heavy metals on microplastic which increased their bioaccumulation. Such toxic complexes of heavy metals and microplastic are a concern to natural ecosystems, so recent ndings of environmental biologists are more focused on it. Few reports also demonstrated, the bio lm formation on microplastic surfaces which might cause greater environmental as well as human health risks. Notably, terms of determining the microplastics in human tissues through several analytical techniques are still limited to some extent. Future research should be focused on the quanti cation of microplastics in human tissues, the combined effect of microplastics with other contaminants, and their effects on the pre-existing diseases. This study boosts understanding of the potential impacts of microplastic and nano-plastic toxicity in the human gastrointestinal system.

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