Investigation of morphology and structure of drug‐loaded PLA‐b‐PEO‐b‐PLA polymeric micelle: A dissipative particle dynamics simulations study
Dongmei Liu,
Ye Lin,
Danping Wang
et al.
Abstract:The dissipative particle dynamics (DPD) simulation was used to study the morphologies and structures of the paclitaxel‐loaded PLA‐b‐PEO‐b‐PLA polymeric micelle. We focused on the influences of PLA block length, PLA‐b‐PEO‐b‐PLA copolymer concentration, paclitaxel drug content on morphologies and structures of the micelle. Our simulations show that: (i) with the PLA block length increase, the self‐assemble structure of PLA‐b‐PEO‐b‐PLA copolymers with paclitaxel vary between onion‐like structure (core‐middle laye… Show more
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