Investigation of multiple factors which may contribute to vitamin D levels of bedridden pregnant women and their preterm neonates

Skouroliakou, Maria; Ntountaniotis, Dimitrios; Massara, Paraskevi; Koutri, Katerina

doi:10.3109/14767058.2015.1094788

Cited by 6 publications

(7 citation statements)

References 25 publications

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“…In the present study, the Pearson correlation coefficient for the serum level of vitamin D in mothers and infants shows a strong and significant relationship between the serum level of vitamin D in mothers and preterm infants. In this context, Skouroliakou et al reported a strong and significant correlation between the serum level of vitamin D in mothers and preterm infants, which confirms the results of the present study [ 20 ]. In the study of Mafinejad et al, a strong and significant relationship was demonstrated between serum levels of vitamin D in mothers and preterm infants, which is in line with the results of the present study.…”

Section: Discussionsupporting

confidence: 92%

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Association between vitamin D level in mother’s serum and the level of vitamin D in the serum of pre-term infants

2023

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Background Vitamin D deficiency and insufficiency is common in mothers and infants. The present study was conducted with the aim of association between the level of vitamin D in the mother’s serum and the level of vitamin D in the serum of preterm infants. Method The present descriptive – analytical study was performed on 140 mothers and preterm infants referred to the Kamali hospital in Alborz University of Medical Sciences. Sampling was done from available mothers after hospitalization for delivery and their infants during the first 72 hours after delivery. Information from mothers and infants were collected with researcher made check list, including age, type of delivery, number of pregnancies, vitamin D during this pregnancy, infants birth age, gender, and birth weight. Data analysis was performed using SPSS version 24 software. Results The average age of mothers was 28 ± 5 years and the average age of infants at the time of birth was 30 ± 1 weeks. Forty two infants (67%) were boys and 23 infants (33%) were girls. The results showed a high rate of vitamin D insufficiency and deficiency in mother (44, 49%) and preterm infants (49, 38%). The results of the Pearson correlation test showed that there is a strong and significant relationship between the serum vitamin D level of mothers and preterm infants (P = 0.001). Logistic regression tests showed that mother’s vitamin D level had an effect on the infant’s vitamin D level. Conclusion Considering high rate of vitamin D deficiency and insufficiency and relationship between vitamin D in preterm infants serum and mothers, diagnostic screenings are recommended to investigate vitamin D disorders in pregnant mothers, which should be planned, implemented and followed up in the form of a therapeutic program to prevent the occurrence of complications caused by this disorder in the mother and infant.

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Section: Discussionsupporting

confidence: 92%

“…In this field, in the study of Skouroliakou et al, the logistic regression model showed the effect of mothers’ serum vitamin D level in predicting the level of more than 20 ng/ml of vitamin D in preterm infants, which confirms the results of the present study [ 20 ].…”

Section: Discussionsupporting

confidence: 89%

Association between vitamin D level in mother’s serum and the level of vitamin D in the serum of pre-term infants

2023

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“…Unadjusted analysis of the association between clinical data and vitamin D levels in the CB that was conducted on 241 mother-infant pairs (72.6% black and 81.3% multiparous) revealed lower vitamin D levels in the cord blood of nulliparous women [31]. Comparable to previous reports we found no difference between the CB vitamin D status and maternal multivitamin supplementation [30, 32]. However, others have reported that the use of multivitamins, which usually include 400 IU vitamin D 3 , is associated with increased concentrations of 25(OH)D in CB [4].…”

Section: Discussionmentioning

confidence: 38%

Prevalence and risk factors for vitamin D insufficiency and deficiency at birth and associated outcome

et al. 2016

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BackgroundOccurrence and consequence of cord blood (CB) vitamin D insufficiency/deficiency has not been adequately explored despite rising concern regarding this topic in pediatrics. This study was designed to determine the rate, maternal risk factors, and clinical outcomes in infants in association with vitamin D insufficient/deficient status at birth.MethodsAmerican Academy of Pediatrics (AAP) defined levels (ng/mL) were utilized to categorize the vitamin D status in CB samples as deficient (5–15), insufficient (16–20), and sufficient (21–100). We used descriptive statistics and multiple regression models to identify the rate and factors associated with vitamin D deficiency/insufficiency and related outcomes in the enrolled mother-infant pairs.ResultsThis prospective study was conducted at a single center on postpartum women and their infants. Vitamin D deficiency and insufficiency was recorded in 38.9 and 29.8% respectively of the 265 CB samples. Deficient CB vitamin D levels in infants were associated with maternal Black, Hispanic, or Asian race/ethnicity, younger age, and increased number of pregnancies. The likelihood for infants to be born with an insufficient vitamin D level increases with younger maternal age and the number of pregnancies as well as Asian ethnicity. We did not find an association between the vitamin D status at birth and pre-discharge clinical characteristics of the neonates.ConclusionsThe likelihood for an infant to be born with vitamin D deficiency/insufficiency is relatively high and is related mainly to younger maternal age, gravidity, and non-White race/ethnicity. Our findings raise a question regarding the adequacy of the AAP recommended vitamin D supplementation requirements without knowing the infant’s vitamin D status at birth.

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“…In our neonatal unit, premature and HIV exposed newborns are supplemented with a multivitamin formula that consists of 400 IU of vitamin D (in each 0.6mls), other essential vitamins, and Omega 3 from fish oil. This is based on recommendations from the national guidelines [ 25 ].…”

Section: Discussionmentioning

confidence: 99%

Vitamin D Status and Associated Factors in Neonates in a Resource Constrained Setting

Bhimji

Naburi

Aboud

et al. 2018

International Journal of Pediatrics

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Vitamin D deficiency (VDD) is emerging as a serious public health problem globally; however due to lack of resources, vitamin D levels are not routinely measured among neonates. The study was conducted to determine vitamin D levels in neonates and factors associated with the same. A cross-sectional study was conducted among neonates admitted at neonatal ward of a tertiary care hospital. Means and proportions were calculated from summarized data in frequency tables. Chi square test was used to determine association between vitamin D and various associated factors such as sex, infant birth weight, gestation age, parity of the mother, maternal age, and HIV status of the mother. A total of 170 neonates were studied, out of which 80% had vitamin D deficiency. Neonates born to HIV-infected mothers were significantly less likely to have vitamin D deficiency (OR 0.21, 95% CI 0.06 – 0.77, p = 0.009). Subgroup analysis revealed the association to be stronger in terms neonates (p = 0.005). The association was not observed among preterm newborns. The prevalence of vitamin D deficiency in neonates was observed to be very high and needs more attention.

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Investigation of multiple factors which may contribute to vitamin D levels of bedridden pregnant women and their preterm neonates

Cited by 6 publications

References 25 publications

Association between vitamin D level in mother’s serum and the level of vitamin D in the serum of pre-term infants

Association between vitamin D level in mother’s serum and the level of vitamin D in the serum of pre-term infants

Prevalence and risk factors for vitamin D insufficiency and deficiency at birth and associated outcome

Vitamin D Status and Associated Factors in Neonates in a Resource Constrained Setting

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