Investigation of nanovesicle liposome powder production from soy lecithin by spray drying

Chun, Ji‐Yeon; Godoi, Fernanda Condi de; Bansal, Nidhi; Morand, Marion; Bhandari, Bhesh

doi:10.1080/07373937.2016.1229333

Cited by 10 publications

(4 citation statements)

References 32 publications

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“…Negative values higher than −35 mV in liposomes were considered to be stable. [ 23 ] Higher negative charge induces sufficient electrostatic repulsion to prevent flocculation and coalescence of emulsion upon reconstitution. High value of ζ‐potential, either positive or negative, means the higher stability governed by the repulsion between the charged double layers of macromolecules.…”

Section: Resultsmentioning

confidence: 99%

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Nanoliposome Powder Containing Shrimp Oil Increases Free Flowing Behavior and Storage Stability

Gulzar

Benjakul

2020

Euro J Lipid Sci & Tech

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Shrimp oil nanoliposomes dried by freeze-drying and spray-drying are characterized, in which carboxy methyl cellulose and fumed silica (SiO 2 ) at various proportions are used as wall material and anti-caking agent. Spray-dried powder (SDP) is spherical in shape with average particle size of 5.33 ± 2.55 µm, while the freeze-dried powder (FDP) having average size of 240.8 ± 237.4 µm is irregular. SDP shows better flowability than FDP, which is more porous with much lower bulk density. Encapsulation efficiency (68.52 ± 1.85%) and solubility (85.22 ± 1.4) of SDP are greater than FDP (51.18 ± 3.81% and 71.25 ± 1.3, respectively) (p < 0.05). However, the wettability of FDP is higher with shorter reconstitution time. FDP exhibits lower oxidation of total encapsulated oil and better retention of n-3 fatty acids (p < 0.05). Overall, both FDP and SDP are thermodynamically stable and the aforementioned powders have the prolonged storage time of six weeks. Practical Applications: Oil from shrimp cephalothorax, a byproduct from shrimp processing industries, is one of the rich sources of omega-3 fatty acids and astaxanthin. Encapsulation of shrimp oil in nanoliposomes is a promising technology, which can be utilized to protect the oil against oxidation and mask the off-odors. Shrimp oil nanoliposome powder prepared using spray-drying and freeze-drying processes and added with the anticaking agents offers numerous advantages such as good flowability, better solubility, and enhanced encapsulation efficiency in addition to the improved oxidative stability and no significant loss of bioactive PUFAs. The shrimp oil nanoliposome powder could be used in the fortification of number of food products, particularly beverages. Moreover, due to the powdered form, the shelf stability is increased, handling and transportation becomes easier, and the cost is significantly reduced.

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Section: Resultsmentioning

confidence: 99%

“…A few studies have shown that liposomes retain their stability and narrow size distribution in the powder form. [ 23 ]…”

Section: Introductionmentioning

confidence: 99%

Nanoliposome Powder Containing Shrimp Oil Increases Free Flowing Behavior and Storage Stability

Gulzar

Benjakul

2020

Euro J Lipid Sci & Tech

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“…High ZP was observed on the surface of the prepared bilosomal formulae, ranged between −30.6 mV and −49.5 mV, as shown in Table 1 and Figure 1(C) . This range could guarantee high physical stability for the bilosomes over the long term due to the significant repulsion between the similarly charged surfaces (Chun et al., 2017 ; Sala et al., 2017 ). A two-factor interaction model was adopted to analyze the measured ZP values.…”

Section: Resultsmentioning

confidence: 99%

Molecular docking and statistical optimization of taurocholate-stabilized galactose anchored bilosomes for the enhancement of sofosbuvir absorption and hepatic relative targeting efficiency

et al. 2020

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The work aimed to improve both absorption and hepatic availability of sofosbuvir. Bilosomes and galactose-anchored bilosomes were investigated as potential nanocarriers for this purpose. Sofosbuvir is a class III drug with high solubility and low permeability. Thus, the drug entrapment into lipid-based galactose-anchored carriers would enhance drug permeability and improve its liver availability. The galactosylated taurocholate was designed and synthesized based on molecular docking studies, where both galactose and taurocholate molecules were connected in a way to avoid affecting crucial interactions and avoid steric clashes with their cellular uptake receptors. The suggested nano-carriers were prepared using a thin-film hydration technique with sodium taurocholate and span 60 as stabilizers. The prepared formulae were statistically optimized using a central composite design. The optimized plain and galactosylated formulae, composed of SAA to drug ratio of 1:1 w/w and sodium taurocholate to span ratio of 10:1 w/w, have a vesicular size, zeta potential and entrapment efficiency in the range of 140–150 nm, −50 mV and 85%, respectively. The optimized formulae were lyophilized to increase their physical stability and facilitate accurate drug dosing. In vivo results showed that Sofosbuvir availability in the liver was significantly increased after oral administration of the plain and the galactosylated bilosomal formulae when compared to the oral drug solution with relative targeting efficiencies (RTIs) of 1.51 and 3.66, respectively. These findings confirmed the hypothesis of considering the galactosylated bilosomes a promising nanocarrier to efficiently target sofosbuvir to the liver.

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“…The spray dried product is then collected from the inner surface of the chamber and hydrated with the buffer solution of needed pH and finally preserved in refrigerator for future use. The technique is very effective for the encapsulation of a number of cargo molecules [100][101][102].…”

Section: Preparationsmentioning

confidence: 99%

Liposomes-The 21st Century’s Drug Delivery System: Developments in the Last Two Decade

Adhikari

2023

ajc

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Liposomes have been thoroughly investigated and are utilized for various illnesses for the past few decades starting from its first discovery in 1961. Since then, therapeutic efficiency of liposomes is enhanced by increasing drug absorbance while fast deterioration and adverse effects are avoided or minimized. This will extend the biological halfway life. Liposomes are more attractive for usage as drug delivery carriers with all of these characteristics and versatility to modify their surface to create additional specific functionalities. In various phases of research, there are numerous new liposomal compositions that improve the therapeutic efficiency of new and old medicines used in pre-clinical and clinical studies. Current multimodal imaging advances aimed at better diagnosing and monitoring liposome therapies as diagnostic tools. Liposomes are major possibilities for medication delivery improvement. Recent researches show that the liposomes can be taken widely in cancer treatments. The primary properties of these structures include minimal toxicity, cytocompatibility, reduced clearance rates, tissue targeting and sustained drug release. Liposomes offer a variety of benefits as shown by approval of Doxil, as compared to traditional chemotherapy with free medication treatment. There are a multitude of liposomes depending on their size, lamellar number, shape and composition. Diagnostic, therapeutic, improved vaccination are covered by clinical use of these systems. Drug and gene delivery are two therapeutic aspects, where due to their unique characteristics liposomes might be beneficial. Several illnesses have been examined with respect to the participation of liposomes, with some good results. Cancer is a life-threatening disease. These structures have been examined in this respect, both in imaging and in chemotherapy. These investigations have resulted in different liposome compositions in different clinical stages. We take this great opportunity to present various surface functionalization strategies and bio-applications of liposomes developed during the last two decades covering the notable work published from 2011 to 2021 in this review. In addition, we provide opinions on the liposome industry, its commercial market and the prospective developments in the field of liposome technology. It is anticipated that this review will serve as a valuable resource, fostering interest and engagement among scientists worldwide in the field of liposome research.

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Investigation of nanovesicle liposome powder production from soy lecithin by spray drying

Cited by 10 publications

References 32 publications

Nanoliposome Powder Containing Shrimp Oil Increases Free Flowing Behavior and Storage Stability

Nanoliposome Powder Containing Shrimp Oil Increases Free Flowing Behavior and Storage Stability

Molecular docking and statistical optimization of taurocholate-stabilized galactose anchored bilosomes for the enhancement of sofosbuvir absorption and hepatic relative targeting efficiency

Liposomes-The 21st Century’s Drug Delivery System: Developments in the Last Two Decade

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