Investigation of neural functional connectivity in thick acute mouse brain slices with novel multi-region 3D neural probe arrays
Wesley Charles Smith,
Zoia Naumkina,
Hyo Geun Shin
et al.
Abstract:There are significant limitations in investigating complex neural circuitsin vivo, including drawbacks to midline-adjacent surgeries, limited accessibility to deep brain regions and number of feasible regional targets for simultaneous recordings, and analytical or experimental biases from recording one columnar plane. On the other hand, recording extracellular neural signalsex vivoorin vitrousing planar microelectrode arrays (MEAs) only permits slice surface recordings, and since conventional slices under 400 … Show more
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