Accelerator Driven Systems (ADS) are an old technological idea: Relativistic proton accelerators deliver their beams onto massive heavy element targets, thus producing abundant neutron fluences. Placing this target into sub-critical nuclear fission assemblies is yielding substantial fission reactions, thus additional fission energy (Rubbia called such a system “Energy Amplifier”). This technology has recently attracted considerable attention due to advances in the construction of powerful accelerators. It allows the safe and cheap production of nuclear energy simultaneously with the destruction (Transmutation) of long lived radioactive waste, in particular plutonium and other minor actinides (neptunium and americium). The principles and the present-state-of-the-art are described, including first experiments to transmute plutonium this way. This technology needs, however, many more years of further “research and development” before large scale ADS's can be constructed. It may be even necessary to investigate the question, if all basic physics phenomena of this technology are already sufficiently well understood.