Investigation of New Dihydropyridine Derivative Solutions by Using of 2d Dosy NMR

Abstract

As a result of the multicomponent condensation reaction between the thiophenylidenemalononitril and malononitriles with (S)-(-)-1-phenylethylamine new heterocyclic dihydropyridine derivative [(S)-(-)-6amino-2-imino-1-(1-phenylethyl)-4-(thiophen-2-yl)-1,2-dihydropyridine-3,5-dicarbonitrile] was synthesized. DMSO-d 6 solutions of the new compound have been investigated in the presence of βcyclodextrin by using the 2D DOSY method. As confirmed by our investigations, water molecules formed the combined intermolecular hydrogen bond with the β-cyclodextrin and sample. Also, the hydrodynamic radius of new dihydropyridine derivative has been calculated.