Investigation of NH<sub>3</sub>absorption by protic imidazolium thiocyanate-based deep eutectic solvents with multiple binding sites and low viscosity

Zhou, Ziyue; Li, Ké; Zong, Kai; Deng, Xiaoxia; Deng, Dongshun

doi:10.1039/d1nj03816h

Cited by 10 publications

(5 citation statements)

References 49 publications

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“…Therefore, we can only say there is a possibility that these systems are protic ionic liquids and not molecular liquids. This possibility also explains the high increase of the solubility of both APIs [ 44 , 45 ].…”

Section: Discussionmentioning

confidence: 99%

Solids Turn into Liquids—Liquid Eutectic Systems of Pharmaceutics to Improve Drug Solubility

et al. 2022

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The low solubility of active pharmaceutical ingredients (APIs) is a problem in pharmaceutical development. Several methodologies can be used to improve API solubility, including the use of eutectic systems in which one of the constituents is the API. This class of compounds is commonly called Therapeutic Deep Eutectic Systems (THEDES). THEDES has been gaining attention due to their properties such as non−toxicity, biodegradability, and being non−expensive and easy to prepare. Since the knowledge of the solid liquid diagram of the mixture and the ideal eutectic point is necessary to ascertain if a mixture is a deep eutectic or just a eutectic mixture that is liquid at ambient temperature, the systems studied in this work are called Therapeutic Liquid Eutectic Systems (THELES). Therefore, the strategy proposed in this work is to improve the solubility of chlorpropamide and tolbutamide by preparing THELES. Both APIs are sulfonylurea compounds used for the treatment of type 2 diabetes mellitus and have low solubility in water. To prepare the THELES, several coformers were tested, namely, tromethamine, L(+)−arginine, L−tryptophan, citric acid, malic acid, ascorbic acid, and p−aminobenzoic acid, in molar ratios of 1:1 and 1:2. To improve viscosity, water was added in different molar ratios to all systems. THELES were characterized by mid−infrared spectroscopy (MIR), and differential scanning calorimetry. Their viscosity, solubility, and permeability were also determined. Their stability at room temperature and 40 °C was accessed by MIR. Cytocompatibility was performed by metabolic activity and cell lysis evaluation, according to ISO10993−5:2009, and compared with the crystalline APIs. THELES with TRIS were successfully synthesized for both APIs. Results showed an increased solubility without a decrease in the permeability of the APIs in the THELES when compared with the pure APIs. The THELES were also considered stable for 8 weeks at ambient temperature. The cells studied showed that the THELES were not toxic for the cell lines used.

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Section: Discussionmentioning

confidence: 99%

Solids Turn into Liquids—Liquid Eutectic Systems of Pharmaceutics to Improve Drug Solubility

et al. 2022

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“…[Im][NO 3 ]/EG (1 : 3) DES possessed a fast absorption rate and reversible NH 3 ability of 0.172 g NH 3 per g DES at 40 °C and 0.1 MPa. Deng et al 164 adopted a similar strategy and prepared series of [Im][SCN]-based DES. Interestingly, these [Im][SCN]-based DES exhibited extremely lower viscosity, better NH 3 absorption and separation selectivity than [Im][NO 3 ]-based DES.…”

Section: Dess Materials For Nh3 Absorptionmentioning

confidence: 99%

Ionic liquids and deep eutectic solvents for NH₃ absorption and separation: a review

Li,

Zong,

Wang

et al. 2023

New J. Chem.

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“…Table summarizes the functional types and NH 3 absorption capacities of representative DESs reported in the literature. − Although DESs can be more easily obtained than ILs, high viscosity is still a drawback of most DESs, which mainly comes from the strong hydrogen-bond interaction between HBAs and HBDs . In addition, most DESs currently reported are constructed from halide compounds, which are highly corrosive to industrial facilities .…”

Section: Liquid Absorptionmentioning

confidence: 99%

A Mini-Review on NH₃ Separation Technologies: Recent Advances and Future Directions

Zhang

Zheng

et al. 2022

Energy Fuels

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NH3 has been recognized as a future carrier of energy considering its high content of H. It can be combusted directly, or decomposed on-site to release H2. For the application of NH3 as an energy carrier, the efficient separation of NH3 is an important task. So far, many technologies such as physical condensation, liquid absorption, solid adsorption, and membrane separation are available for the separation of NH3. Recently, the integration of physical condensation and solid adsorption was also proposed for the separation of NH3, to simultaneously utilize the advantages of both technologies. However, an up-to-date review providing an overall description of NH3 separation technologies is still absent. In this mini-review, we briefly summarized the recent advances in NH3 separation technologies, and mainly discussed the publications in the past five years. First, we sequentially introduced physical condensation, liquid absorption, solid adsorption, membrane separation, and integration technologies. Then, the future directions for the development of NH3 separation technologies were analyzed.

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Investigation of NH₃absorption by protic imidazolium thiocyanate-based deep eutectic solvents with multiple binding sites and low viscosity

Abstract: Protic [Im][SCN]-based DESs with multiple binding sites and low viscosity for NH3 capture and separation are reported.

Cited by 10 publications

References 49 publications

Solids Turn into Liquids—Liquid Eutectic Systems of Pharmaceutics to Improve Drug Solubility

Solids Turn into Liquids—Liquid Eutectic Systems of Pharmaceutics to Improve Drug Solubility

Ionic liquids and deep eutectic solvents for NH₃ absorption and separation: a review

A Mini-Review on NH₃ Separation Technologies: Recent Advances and Future Directions

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Investigation of NH3absorption by protic imidazolium thiocyanate-based deep eutectic solvents with multiple binding sites and low viscosity

Abstract: Protic [Im][SCN]-based DESs with multiple binding sites and low viscosity for NH3 capture and separation are reported.

Cited by 10 publications

References 49 publications

Solids Turn into Liquids—Liquid Eutectic Systems of Pharmaceutics to Improve Drug Solubility

Solids Turn into Liquids—Liquid Eutectic Systems of Pharmaceutics to Improve Drug Solubility

Ionic liquids and deep eutectic solvents for NH3 absorption and separation: a review

A Mini-Review on NH3 Separation Technologies: Recent Advances and Future Directions

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Product

Resources

About

Investigation of NH₃absorption by protic imidazolium thiocyanate-based deep eutectic solvents with multiple binding sites and low viscosity

Ionic liquids and deep eutectic solvents for NH₃ absorption and separation: a review

A Mini-Review on NH₃ Separation Technologies: Recent Advances and Future Directions