Investigation of non-HDL cholesterol and C-reactive protein in diabetes patients

Hsu, Wen-Tung; Pien, Hsiu-Chuan; Huang, Hai-I; Tu, Yi-Yu; Kuo, Wu‐Hsien; Tsai, Kwang-Yang; Chen, Li-Mien

doi:10.1016/j.bgm.2013.08.002

Cited by 3 publications

(2 citation statements)

References 11 publications

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“…In a study conducted by Wang and Chang in a diabetic patient group, it was shown that non-HDL-C correlates with CRP levels and non-HDL-C is an independent predictor for in ammation in this patient group [15]. Hsu et al found results which were similar to those in Wang's work [31]. It has been suggested in a recent study that non-HDL-C may be superior to CRP in determining future cardiovascular events in children and adolescents with type 1 diabetes [32].…”

Section: Discussionsupporting

confidence: 64%

The relationship between non-HDL cholesterol and coronary collateral circulation

Yıldırım¹,

Se²,

Argan³

et al. 2020

Preprint

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Objective Non high density lipoprotein cholesterol (non HDL-C) covers all aterojenic lipoproteins and correlates with C reactive protein (CRP) which is reliable marker of inflammation. CRP is related to poor angiographic coronary collateral circulation (CCC). We aimed to show whether non HDL-C is associated with CCC.Methods Patients who underwent coronary angiography for stable coronary artery disease and at least one epicardial coronary artery occluded in the proximal or middle region were included in the study. Accrording to the Rentrop scoring system Rentrop 0 and 1 were considered to be poor CCC, and Rentrop 2 and 3 were considered to be good CCC. Non-HDL-C was calculated by subtracting HDL-C from total cholesterol (TC).Results 84 patients were included in the study. While 44 patients (52%) had good CCC, 40 patients (48%) had poor CCC. TC was found to be higher in the poor CCC group than in the good CCC group (224.3 ± 35.6 vs 179.2 ± 25.5 p = 0.000). HDL-C levels were found to be lower in the poor CCC group than in the good CCC group (37.3 ± 9.8 vs 44.1 ± 8.6 p = 0.001). Non-HDL-C cholesterol levels were higher in the group with poor CCC (185.7 ± 39.2 vs 132.8 ± 28.1 p = 0.000). CRP levels were found to be higher in the poor CCC group (3.73 ± 2.5 vs 1.67 ± 1.4 p = 0,000).Conclusion Non-HDL-C is independent predictors of poor CCC.

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Section: Discussionsupporting

confidence: 64%

The relationship between non-HDL cholesterol and coronary collateral circulation

Yıldırım¹,

Se²,

Argan³

et al. 2020

Preprint

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show abstract

“…The lack of association in this study might be attributed to the small sample size. On the other hand, a number of studies have explored the relationship of CRP with lipids level in diabetic patients, with conflicting results [14,15]. Also, possible explanation for these results are facts that a newly diagnosed patients with T2D and there were yet not disturbed lipid metabolism and lipid levels is in reference range/interval.…”

Section: Resultsmentioning

confidence: 99%

Association of Marker of Inflammation, Hepatic Enzymes and Lipid Profile in Type 2 Diabetes

Mandal¹

2022

RAD Conference Proceedings

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Type 2 diabetes mellitus (T2D) is a condition characterized by hyperglycemia as well as chronic inflammation, and is associated with disturbed lipids metabolism and impaired hepatic function. It is well known that the liver plays a key role in maintenance of normal glucose levels during the fasting and post prandial periods while C reactive protein as a marker of inflammation is produced in the liver. Altered lipoprotein levels and elevated hepatic enzymes have been identified as an independent risk factor for the development of many metabolic disorders including T2D. Aim of this study was to evaluate C-reactive protein (CRP) as well hepatic enzymes and to find their association with the lipid profile in non-treated T2D patients. Biochemical parameters, CRP, hepatic enzymes (alanine amino transferase, aspartate amino transferase, gamma-glutamyl transferase, and alkaline phosphatase) were measured by using VITROS 350 Chemistry System. Glycemic control parameters, lipid profile and liver enzymes were increased in diabetics and differed from control group (p<0.001). The significant association between CRP with HDL levels as well as association of ALT and GGT activity with HDL levels was observed in control group. Also, a negative association of GGT with VLDL levels was revealed in healthy subjects. In non-treated diabetics a negative significant association between AST and HDL levels as well as a positive association of AST and LDL levels was found while lack of association between lipid profile and other liver enzymes. Interestingly, in diabetes patients a negative association between CRP and AP levels was observed. These findings suggest that marker of inflammation (CRP), hepatic enzymes activities and impaired lipid metabolism may play an important role in pathogenesis of T2D and related complications.

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Non-HDL cholesterol predictive factor of type 2 diabetes in the city of Tlemcen

Dali-Sahi

Kachekouche

Dennouni-Medjati

et al. 2019

Diabetes & Metabolic Syndrome: Clinical Research & Revi

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Investigation of non-HDL cholesterol and C-reactive protein in diabetes patients

Cited by 3 publications

References 11 publications

The relationship between non-HDL cholesterol and coronary collateral circulation

The relationship between non-HDL cholesterol and coronary collateral circulation

Association of Marker of Inflammation, Hepatic Enzymes and Lipid Profile in Type 2 Diabetes

Non-HDL cholesterol predictive factor of type 2 diabetes in the city of Tlemcen

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