Investigation of Nonlinear Magnetic Properties Magneto-Mechano-Chemical Synthesized Nanocomplex from Magnetite and Antitumor Antibiotic Doxorubicin

Орел, В.Е.; Shevchenko, A. V.; Rykhalskiy, A. Y.; Burlaka, Anatoliy; Лукин, С. Н.; Schepotin, I.

doi:10.1007/978-3-319-06611-0_8

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Antitumor effect of superparamagnetic iron oxide nanoparticles conjugated with doxorubicin during magnetic nanotherapy of Lewis Lung carcinoma

Орел

Romanov

Rykhalskyi

et al. 2016

Materialwissenschaft Werkst

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Superparamagnetic Iron(II,III) oxide Fe 3 O 4 nanoparticles (NP) in magnetic nanocomplex (MNC2) with antitumor drug doxorubicin (DOXO) induced a greater antitumor and antimetastatic effect compared to the magnetic nanocomplex (MNC1) composed of ferromagnetic nanoparticles with DOXO and conventional DOXO during magnetic nanotherapy of animals with Lewis lung carcinoma. The intratumor temperature did not exceed 39°C. MNC2 had g-factors of 2.00, 2.30 and 4.00. MNC1 had the g-factor of 2.50. The MNC2 increased the content of Nitric oxide -Iron(II) sulfide protein N complex and NADH-ubiquinone in tumor as compared to MNC1 or conventional DOXO. The results have been analyzed in terms of increased level of reactive oxygen species which could induce death of tumor cells.

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