Investigation of novel alginate−magnesium aluminum silicate microcomposite films for modified-release tablets

Pongjanyakul, Thaned; Priprem, Aroonsri; Puttipipatkhachorn, Satit

doi:10.1016/j.jconrel.2005.07.003

Cited by 88 publications

(39 citation statements)

References 27 publications

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“…It is also used as coverage material for food preservation and as burn dressing material. Although alginate films have been studied up to now [2,3], only few research reports exist showing the addition of layered silicates to alginate polymer for different purposes [4][5][6]. Calcium alginate barrier films modified by montmorillonite clay were prepared for decreasing the permeation of small molecules through calcium alginate films [4].…”

Section: Introductionmentioning

confidence: 99%

Biocomposite films based on alginate and organically modified clay

Tezcan

Günister

Özen

et al. 2012

International Journal of Biological Macromolecules

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Section: Introductionmentioning

confidence: 99%

Biocomposite films based on alginate and organically modified clay

Tezcan

Günister

Özen

et al. 2012

International Journal of Biological Macromolecules

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“…A host of different constituents were used in the polymeric part of these hybrid materials, ranging from chitosan (14,28,36-38,56,72), alginate (51,62,71), guar gum (22) and hyaluronic acid (72), to synthetic polyvinyl alcohol (48,49), poly (lactic-co-glycolic acid) (32,57,69), polyurethane (4,6,21,34,35), and poly(L-lactic acid) (5,8,63), among others. These polymers were employed predominantly as matrices (22,26,32,35,49,66,74,89), but in some cases formed the composite coating (64,70,71).…”

Section: Polymersmentioning

confidence: 99%

Clay and Polymer-Based Composites Applied to Drug Release: A Scientific and Technological Prospection

Meirelles

Raffin

2017

J Pharm Pharm Sci

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-There has been a growing trend in recent years for the development of hybrid materials, called composites, based on clay and polymers, whose innovative properties render them attractive for drug release. The objective of this manuscript was to conduct a review of original articles on this topic published over the last decade and of the body of patents related to these carriers. A scientific prospection was carried out spanning the period from 2005 to 2015 on the Web of Science database. The technological prospection encompassed the United States Patent and Trademark Office, the European Patent Office, the World International Patent Office and the National Institute of Industrial Property databases, filtering patents with the code A61K. The survey revealed a rise in the number of publications over the past decade, confirming the potential of these hybrids for use in pharmaceutical technology. Through interaction between polymer and clay, the mechanical and thermal properties of composites are enhanced, promoting stable, controlled drugs release in biological media. The most cited clays analyzed in the articles was montmorillonite, owing to its high surface area and capacity for ion exchange. The polymeric part is commonly obtained by copolymerization, particularly using acrylate derivatives. The hybrid materials are obtained mainly in particulate form on a nanometric scale, attaining a modified release profile often sensitive to stimuli in the media. A low number of patents related to the topic were found. The World International Patent Office had the highest number of lodged patents, while Japan was the country which published the most patents. A need to broaden the application of this technology to include more therapeutic classes was identified. Moreover, the absence of regulation of nanomaterials might explain the disparity between scientific and technological output.

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“…Nowadays, composite hydrogels of polysaccharides were fabricated, and displayed improved properties, such as swelling/absorption of water, mechanical/thermal behavior, higher specific strength, lower specific gravity, higher resistances to corrosion and oxidation [20][21][22][23]. Many candidates, mineral clays [24], polyurethane [25], polyvinyl alcohol (PVA) [26] and polyvinyl chloride (PVC) [27], have been used to take shape composites hydrogel with chitosan.…”

Section: Introductionmentioning

confidence: 99%

Preparation of polyvinyl alcohol/chitosan hydrogel compounded with graphene oxide to enhance the adsorption properties for Cu(II) in aqueous solution

Wang

et al. 2015

J Polym Res

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A novel bio-adsorbent, composite hydrogel beads, composed of polyvinyl alcohol (PVA), chitosan (CS) and graphene oxide (GO) was prepared by an instantaneous gelation method. The micromorphology and thermal stability of the PVA/CS/GO hydrogel beads were characterized by scanning electronic microscope (SEM) and thermo gravimetric analysis (TGA) respectively. Adsorption of Cu(II) onto PVA/CS/GO hydrogel beads was investigated with respect to pH, initial concentration, temperature and adsorption time. Adsorption data were well matched by Langmuir isotherm and pseudo-second-order kinetic model at the optimum pH 5.5. The maximum adsorption capacities of PVA/CS/GO hydrogel beads were found to be 162 mg g −1 for Cu(II) at 30°C, which was much higher than that of PVA/CS hydrogel. Thermodynamic studies indicated that the adsorption was spontaneous and endothermic process in nature. Besides, desorption efficiency and reusability of the adsorbents were assessed on basis of six consecutive adsorption-desorption cycles. Based on these studies, it can be seen that PVA/CS/ GO hydrogel beads will be a potential recyclable adsorbent for removal of hazardous metal ions in waste water.

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Investigation of novel alginate−magnesium aluminum silicate microcomposite films for modified-release tablets

Cited by 88 publications

References 27 publications

Biocomposite films based on alginate and organically modified clay

Biocomposite films based on alginate and organically modified clay

Clay and Polymer-Based Composites Applied to Drug Release: A Scientific and Technological Prospection

Preparation of polyvinyl alcohol/chitosan hydrogel compounded with graphene oxide to enhance the adsorption properties for Cu(II) in aqueous solution

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