In radial inflow turbine design, the optimization of turbine geometry for aerodynamic performance improvement is often constrained by the requirement of reliability, thus facing a trade-off. One of the vital challenges for a better trade-off is how to mitigate the forced response of turbine wheel, while maintaining high efficiency, so as to avoid high cycle fatigue failure. In this article, using a grooved surface on nozzle vanes for the forced response reduction was investigated. In light of the fact that the investigation on the high cycle fatigue issue involves both aerodynamic interactions and structural analyses, a customized computer code was developed using MATLAB software to couple computational fluid dynamics simulations with finite element analysis calculations. Partial results were compared against experimental results, respectively, to validate the numerical method. The coupled numerical method reveals that using the grooved surface on the nozzle vane alters the shock wave structure, decreases the peak stress of turbine wheel by 8%, and deteriorates turbine efficiency by 0.05 percentage points.