Investigation of nucleophilic substitution pathway for the reactions of 1,4-benzodioxan-6-amine with chlorocyclophosphazenes

Chiral configurations in cyclophosphazene chemistry

“…If the two centers of chirality are different then 1,3-disubstitution should give two racemic diastereoisomers, though no examples are yet known. If the two centers of chirality are the same, then 1,3-disubstitution should still give two diastereoisomers, where the 1,3-trans arrangement of substituents leads to a racemate as found for compounds 93a* [111], 93b* [112], 93c* [113] and the 1,3-cis arrangement gives a meso derivative as found for compounds 94* [114] and 95 [115]. The 1,5-disubstituted cyclotetraphosphazenes have no analogy in cyclotriphosphazene derivatives and their stereogenic properties also depend on substitution at the 3,7 positions.…”

“…Compound 123 [156] which has a pseudoasymmetric center is a meso form. Although it is of interest to find that a number of metallo-cyclotriphosphazenes have centers of chirality and that they exist in racemic or meso forms (107)(108)(109)(110)(111)(112)(113)(114)(115)(116)(117)(118)(119)(120)(121)(122)(123), it is perhaps more important for the synthetic chemist to understand what structural types lead to metallocyclophosphazenes with centers of chirality, especially because an achiral molecule may become chiral after complexation. The compounds (107)(108)(109)(110)(111)(112)(113)(114)(115)(116)(117)(118)(119)(120)(121)(122)(123) should be sub-divided into catagories that depend primarily on the number of binding sites of the metal to the cyclophosphazene derivative and then by the configurational arrangement of the substituents involved in the binding and whether skeletal nitrogens are also involved in complexation, because this leads to great diversity of binding modes.…”

Novel BODIPY-bridged cyclotriphosphazenes

“…Nucleophilic substitution reactions of phosphazenes with functional groups (alcohols, amines, thiols, etc.) have been widely studied [12][13][14][15]. Recently, derivatization of a phosphazene core with organic chromophores has attracted much attention.…”

Nucleophilic substitution reactions of monofunctional nucleophilic reagents with cyclotriphosphazenes containing 2,2-dioxybiphenyl units

“…The substitution type in the cyclotriphosphazene ring is directed by electronic, steric, and mechanistic effects [10][11][12][13]. When electron donating groups are on the N 3 P 3 ring, the positive charge at the phosphor atoms reduce and monofunctional alcohols react almost exclusively by the nongeminal pathway [14].…”