Investigation of numerical models for planning of electrochemotherapy treatments of invasive ductal carcinoma

Electrochemotherapy is a selective electrical-based cancer treatment. A thriving treatment depends on the local electric field generated by pairs of electrodes. Electrode damage as deflection can directly affect this treatment pillar, the distribution of the electric field. Mechanical deformations such as tip misshaping and needle deflection are reported with needle electrode reusing in veterinary electrochemotherapy. We performed in vitro and in silico experiments to evaluate potential problems with ESOPE type II electrode deflection and potential treatment pitfalls. We also investigated the extent to which the electric currents of the electroporation model can describe deflection failure by comparing in vitro with the in silico model of potato tuber (Solanum tuberosum). The in silico model was also performed with the tumor electroporation model, which is more conductive than the vegetal model. We do not recommend using deflected electrodes. We have found that a deflection of ± 2 mm is unsafe for treatment. Inward deflection can cause dangerous electrical current levels when treating a tumor and cannot be described with the in silico vegetal model. Outward deflection can cause blind spots in the electric field.

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Investigation of numerical models for planning of electrochemotherapy treatments of invasive ductal carcinoma

Cited by 5 publications

References 12 publications

Electrochemotherapy Effectiveness Loss Due to Electrode Bending: An In Silico and In Vitro Study

Electrochemotherapy Effectiveness Loss Due to Electrode Bending: An In Silico and In Vitro Study

Evaluation and Quantification of Electrode Arrangement Performance for Electrochemotherapy

Electrochemotherapy treatment safety under parallel needle deflection

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