Investigation of obesogenic effects of hexachlorobenzene, DDT and DDE in male rats

Report of the Scientific Committee of the Spanish Agency for Food Safety and Nutrition (AESAN) on the available evidence in relation to the potential obesogenic activity of certain chemical compounds that may be present in foods

“…perature, cold tolerance and energy expenditure, and a transient increase in body fat, in the female offspring when they reached the adult stage(vonder Embse et al, 2021), concluding that exposure to DDT and DDE produces a decrease in the thermogenesis of brown adipose tissue in rodents.However, in other studies such asAl-Obaidi et al (2022), performed in rats, a reduction in the browning of white adipose tissue has been observed, with no changes in thermogenesis in brown adipose tissue after 5 weeks of treatment with DDT or DDE.…”

Effects of chronic high fat diet on mediobasal hypothalamic satiety neuron function in POMC-Cre mice

“…Obesity is a major cause of the metabolic syndrome, which includes insulin resistance, type 2 diabetes, and dyslipidemia. Although the precise mechanisms by which obesity induces or exacerbates metabolic risk factors are still unknown, excessive fat accumulation, particularly increased visceral fat is associated with insulin resistance and abnormal glucose and lipid metabolism [ 2 , 4 ]. In addition, chronic low-grade inflammation in adipose tissue contributes to the pathogenesis of insulin resistance and metabolic syndrome [ 38 ].…”

“…Obesity is a chronic and multifactorial disease that is defined as the accumulation of fat in the body as a result of an imbalance between calorie intake and energy expenditure [ 1 , 2 ]. This complex condition not only creates health risks of its own, but also increases the likelihood of other diseases affecting various body systems.…”

Effect of Pesticides on Peroxisome Proliferator-Activated Receptors (PPARs) and Their Association with Obesity and Diabetes

“…Furthermore, in a mixture of mancozeb and imidacloprid, the increase in cholesterol and triglycerides is enhanced [78]. Including organophosphate, DDT, and DDE could alter adipogenesis processes and reduce PPARγ expression [79]. Another organophosphate, chlorpyrifos promotes obesity but is not related to the expression of PPARγ, it alters mitochondrial function and thermogenesis in mice [7].…”