Investigation of pH-Sensitive Swelling and Curcumin Release Behavior of Chitglc Hydrogel

Deka, Chayanika; Deka, Deepanwita; Bora, Montu Moni; Jha, Dhruva Kumar; Kakati, Dilip Kumar

doi:10.1007/s10924-018-1272-x

Cited by 11 publications

(3 citation statements)

References 44 publications

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“… 58 In this context, it should be noted that the deswelling/swelling rate of PAAVSA/Fe 3 O 4 is ∼0.3 g/(g·min) (i.e., about 17 g/(g·h)), which is very much compatible with the requisite rates for the controlled drug release process for various drug delivery systems. 59 Thus, the pH-sensitive PAAVSA/Fe 3 O 4 magnetic hydrogel with its pH-dependent sustained loading/release profile indicates its potential to be used in site-specific delivery of drugs 60 for controlled drug transport applications with a requirement of sustained delivery over a longer time period/prolonged drug retention time, such as local gastric diseases (e.g., gastritis, gastric ulcer, and gastric carcinoma), 61 in vitro release of the drug (e.g., curcumin) to cure cuts and burns, 62 as an anticancer drug carrier, 47 in tumors, and in diseased blood vessel. 63 In this context, it should be noted that the biocompatibility (cytotoxicity) of the hydrogel (for 72 h) was evaluated with HEK-293 cells and discussed elsewhere, 37 where the biocompatible and nontoxic nature of the hydrogel was observed.…”

Section: Results and Discussionmentioning

confidence: 99%

Target-Specific Superparamagnetic Hydrogel with Excellent pH Sensitivity and Reversibility: A Promising Platform for Biomedical Applications

2020

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Superparamagnetism has been widely used for many biomedical applications, such as early detection of inflammatory cancer and diabetes, magnetic resonance imaging (MRI), hyperthermia, etc., whereas incorporation of superparamagnetism in stimulus-responsive hydrogels has now gained substantial interest and attention for application in these fields. Recently, pH-responsive superparamagnetic hydrogels showing the potential use in disease diagnosis, biosensors, polymeric drug carriers, and implantable devices, have been developed based on the fact that pH is an important environmental factor in the body and some disease states manifest themselves by a change in the pH value. However, improvement in pH sensitivity of magnetic hydrogels is a dire need for their practical applications. In this study, we report the distinctly high pH sensitivity of new synthesized dual-responsive magnetic hydrogel nanocomposites, which was accomplished by copolymerization (free-radical polymerization) of two pH-sensitive monomers, acrylic acid (AA) and vinylsulfonic acid (VSA) with an optimum ratio, in the presence of presynthesized superparamagnetic iron oxide nanoparticles (Fe 3 O 4 (OH) x ). The monomers contain pH-sensitive functional groups (COO – and SO 3 – for AA and VSA, respectively), and they have also been widely used as biomaterials because of the good biocompatibility. The pH sensitivity of the superparamagnetic hydrogel, poly(acrylic acid- co -vinylsulfonic acid), PAAVSA/Fe 3 O 4 , was investigated by swelling studies at different pH values from pH 7 to 1.4. Distinct pH reversibility of the system was also demonstrated through swelling/deswelling analysis. Thermal stability, chemical configuration, magnetic response, and structural properties of the system have been explored by suitable characterization techniques. Furthermore, the study reveals a pH-responsive significant change in the overall morphology and packing fraction of iron oxide nanoparticles in PAAVSA/Fe 3 O 4 via energy-dispersive X-ray (EDX) elemental mapping with the field emission scanning electron microscopy (FESEM) study (for freeze-dried PAAVSA/Fe 3 O 4 , swelled at different pH values), implying a drastic change in susceptibility and induced saturation magnetization of the system. These important features could be easily utilized for the purpose of diagnosis using magnetic probe and/or impedance analysis techniques.

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Section: Results and Discussionmentioning

confidence: 99%

Target-Specific Superparamagnetic Hydrogel with Excellent pH Sensitivity and Reversibility: A Promising Platform for Biomedical Applications

2020

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“…Moreover, a network-like structure was developed because of hydrogen bonds between the bound water molecules and more water molecules. Finally, higher swelling is caused by excess water, which enters the hydrogel's network [30]. Maximum hydrogel swelling was observed at low pH.…”

Section: Ph-sensitivity On Swelling Behavior Of Chitosan and Chitosanmentioning

confidence: 99%

Antibacterial Properties and pH Sensitive Swelling of Insitu Formed Silver-Curcumin Nanocomposite Based Chitosan Hydrogel

El‐Hady

Saeed

2020

Polymers

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A simple method was used to prepare curcumin/silver nanocomposite based chitosan hydrogel. In an alkaline medium, chitosan and chitosan nanocomposite hydrogels were prepared using the physical crosslinking method. The prepared hydrogels were stable for a long period at room temperature. In one step, silver nanoparticles were prepared insitu using silver nitrate solution and curcumin oxide within the hydrogel network formation. In the meantime, curcumin compound served as both a reducing and stabilizing agent. The structure and surface morphology of nanocomposite hydrogels were characterized by FTIR, SEM, and EDX analysis confirmed the formation of silver nanoparticles within the hydrogel network. Moreover, Images of TEM showed a spherical shape of silver nanoparticles with an average size of 2–10 nm within the matrix of the hydrogel. The formation mechanism of nanocomposite based hydrogel was reported. Besides that, the effect of chitosan and silver nitrate concentrations were studied. The swelling capacity of the prepared nanocomposite hydrogels was also performed at different pH of 4, 7, and 9. From the experimental results, the swelling capacity of hydrogels depends on the concentrations of chitosan and silver nitrate. The prepared composite based hydrogel exceeds a higher swelling degree than chitosan hydrogels at low pH. The antibacterial activity of the nanocomposite hydrogels was also examined; the results showed that the prepared nanocomposite hydrogels outperformed the pure chitosan hydrogels. This shows them to be a promising material for the biomedical field as a wound dressing and drug release.

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“…The results suggest their anti-inflammatory effect, enhancing vascularization properties, faster wound closure, and other important factors contributing to wound repair, such as improved epidermis and dermis regeneration or better collagen deposition [58]. The sustained curcumin release profile from the composites contributes to enhanced antibacterial properties, reducing the probability of infection and the healing time [53,[60][61][62]. In vivo research showed that when synthesized using a hot, high-pressure homogenization technique, curcumin solid lipid nanoparticle hydrogels remain stable under autoclave conditions as well as photostable.…”

Section: Wound Healingmentioning

confidence: 98%

Wondrous Yellow Molecule: Are Hydrogels a Successful Strategy to Overcome the Limitations of Curcumin?

Stachowiak,

Mlynarczyk,

Dlugaszewska

2024

Molecules

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Curcumin is a natural compound with a great pharmaceutical potential that involves anticancer, anti-inflammatory, antioxidant, and neuroprotective activity. Unfortunately, its low bioavailability, instability, and poor water solubility significantly deteriorate its clinical use. Many attempts have been made to overcome this issue, and encapsulating curcumin in a hydrogel matrix may improve those properties. Hydrogel formulation is used in many drug delivery forms, including classic types and novel forms such as self-assembly systems or responsive to external factors. Reviewed studies confirmed better properties of hydrogel-stabilized curcumin in comparison to pure compound. The main enhanced characteristics were chemical stability, bioavailability, and water solubility, which enabled these systems to be tested for various diseases. These formulations were evaluated for wound healing properties, effectiveness in treating skin diseases, and anticancer and regenerative activity. Hydrogel formulation significantly improved biopharmaceutical properties, opening the opportunity to finally see curcumin as a clinically approved substance and unravel its therapeutic potential.

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Investigation of pH-Sensitive Swelling and Curcumin Release Behavior of Chitglc Hydrogel

Cited by 11 publications

References 44 publications

Target-Specific Superparamagnetic Hydrogel with Excellent pH Sensitivity and Reversibility: A Promising Platform for Biomedical Applications

Target-Specific Superparamagnetic Hydrogel with Excellent pH Sensitivity and Reversibility: A Promising Platform for Biomedical Applications

Antibacterial Properties and pH Sensitive Swelling of Insitu Formed Silver-Curcumin Nanocomposite Based Chitosan Hydrogel

Wondrous Yellow Molecule: Are Hydrogels a Successful Strategy to Overcome the Limitations of Curcumin?

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