Investigation of phosphorous doping effects on polymeric carbon dots: Fluorescence, photostability, and environmental impact

Zhi, Bo; Gallagher, Miranda J.; Frank, Benjamin; Lyons, Taeyjuana Y.; Qiu, Tian A.; Da, Joseph; Mensch, Arielle C.; Hamers, Robert J.; Rosenzweig, Zeev; Fairbrother, D. Howard; Haynes, Christy L.

doi:10.1016/j.carbon.2017.12.004

Cited by 130 publications

(93 citation statements)

References 86 publications

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“…Consistent with the TEM image, Gly‐CDs showed high monodispersity, with a calculated average size of 11.4 nm. As shown by the X‐ray diffraction (XRD) pattern in Figure 1c, Gly‐CDs possessed the component of amorphous carbon due to the broad peak at around 20° 48. The sharp peak at around 14.9° may be ascribed to the crystallinity of Gly‐CDs, and the graphitic carbon accounted for only a small amount of Gly‐CDs carbon, so no apparent lattice fringe could be observed in the TEM image 49.…”

Section: Resultssupporting

confidence: 62%

Glycyrrhizic‐Acid‐Based Carbon Dots with High Antiviral Activity by Multisite Inhibition Mechanisms

Tong

Zhou

et al. 2020

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With the gradual usage of carbon dots (CDs) in the area of antiviral research, attempts have been stepped up to develop new antiviral CDs with high biocompatibility and antiviral effects. In this study, a kind of highly biocompatible CDs (Gly‐CDs) is synthesized from active ingredient (glycyrrhizic acid) of Chinese herbal medicine by a hydrothermal method. Using the porcine reproductive and respiratory syndrome virus (PRRSV) as a model, it is found that the Gly‐CDs inhibit PRRSV proliferation by up to 5 orders of viral titers. Detailed investigations reveal that Gly‐CDs can inhibit PRRSV invasion and replication, stimulate antiviral innate immune responses, and inhibit the accumulation of intracellular reactive oxygen species (ROS) caused by PRRSV infection. Proteomics analysis demonstrates that Gly‐CDs can stimulate cells to regulate the expression of some host restriction factors, including DDX53 and NOS3, which are directly related to PRRSV proliferation. Moreover, it is found that Gly‐CDs also remarkably suppress the propagation of other viruses, such as pseudorabies virus (PRV) and porcine epidemic diarrhea virus (PEDV), suggesting the broad antiviral activity of Gly‐CDs. The integrated results demonstrate that Gly‐CDs possess extraordinary antiviral activity with multisite inhibition mechanisms, providing a promising candidate for alternative therapy for PRRSV infection.

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Section: Resultssupporting

confidence: 62%

Glycyrrhizic‐Acid‐Based Carbon Dots with High Antiviral Activity by Multisite Inhibition Mechanisms

Tong

Zhou

et al. 2020

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165

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“…These observations indicate that the variation in the surface functional groups according to EDA use induced a remarkable inuence on the morphology. 45 Fouriertransform infrared (FT-IR) spectroscopy, XPS, and 31 P NMR measurements were conducted to identify functional group variations on the CD surfaces. The FT-IR spectrum of alendronate revealed the characteristic absorptions of amine at 3476.21 cm À1 and the phosphorous stretching region at 1043.6, 1014.63 (V s , V as of PO 3 ), and 912.83 cm À1 (V, POH), as shown in Fig.…”

Section: Resultsmentioning

confidence: 99%

Bone-targeting carbon dots: effect of nitrogen-doping on binding affinity

Lee

Park

et al. 2019

RSC Adv.

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“…For this study, CAEDADs were synthesized as previously reported. [18] In brief, 2 ml of 4 M aqueous CA solution (8 mmol) was transferred into a 100-ml beaker, and then 540 μl (8.09 mmol) of EDA was added. The mixture was stirred for 30 min and allowed to cool.…”

Section: Synthesis Of Caedadsmentioning

confidence: 99%

“…[13] "Bottom-up" fluorescent nanoparticles synthesized by low-temperature reaction of citric acid (CA) with amines have attracted attention from multiple research groups. [4,11,[13][14][15][16][17][18][19] The resulting carbon dots exhibit high quantum yields, long fluorescence lifetimes, tunable emission, low toxicity, good biocompatibility, and mild, low-cost synthesis conditions. Following precedent, we refer to these materials as CA carbon dots, or CACDs.…”

Section: Introductionmentioning

confidence: 99%

A molecular fluorophore in citric acid/ethylenediamine carbon dots identified and quantified by multinuclear solid‐state nuclear magnetic resonance

Duan

Zhi

Coburn

et al. 2020

Magnetic Reson in Chemistry

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The composition of fluorescent polymer nanoparticles, commonly referred to as carbon dots, synthesized by microwave-assisted reaction of citric acid and ethylenediamine was investigated by 13 C, 13 C{ 1 H}, 1 H─ 13 C, 13 C{ 14 N}, and 15 N solid-state nuclear magnetic resonance (NMR) experiments. 13 C NMR with spectral editing provided no evidence for significant condensed aromatic or diamondoid carbon phases. 15 N NMR showed that the nanoparticle matrix has been polymerized by amide and some imide formation. Five small, resolved 13 C NMR peaks, including an unusual ═CH signal at 84 ppm (1 H chemical shift of 5.8 ppm) and ═CN 2 at 155 ppm, and two distinctive 15 N NMR resonances near 80 and 160 ppm proved the presence of 5-oxo-1,-2,3,5-tetrahydroimidazo[1,2-a]pyridine-7-carboxylic acid (IPCA) or its derivatives. This molecular fluorophore with conjugated double bonds, formed by a double cyclization reaction of citric acid and ethylenediamine as first shown by Y. Song, B. Yang, and coworkers in 2015, accounts for the fluorescence of the carbon dots. Cross-peaks in a 1 H─ 13 C HETCOR spectrum with brief 1 H spin diffusion proved that IPCA is finely dispersed in the polyamide matrix. From quantitative 13 C and 15 N NMR spectra, a high concentration (18 ± 2 wt %) of IPCA in the carbon dots was determined. A pronounced gradient in 13 C chemical-shift perturbations and peak widths, with the broadest lines near the COO group of IPCA, indicated at least partial transformation of the carboxylic acid of IPCA by amide or ester formation.

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Investigation of phosphorous doping effects on polymeric carbon dots: Fluorescence, photostability, and environmental impact

Cited by 130 publications

References 86 publications

Glycyrrhizic‐Acid‐Based Carbon Dots with High Antiviral Activity by Multisite Inhibition Mechanisms

Glycyrrhizic‐Acid‐Based Carbon Dots with High Antiviral Activity by Multisite Inhibition Mechanisms

Bone-targeting carbon dots: effect of nitrogen-doping on binding affinity

A molecular fluorophore in citric acid/ethylenediamine carbon dots identified and quantified by multinuclear solid‐state nuclear magnetic resonance

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