Investigation of Plasma Inflammatory Profile in Diabetic Patients With Abdominal Aortic Aneurysm: A Pilot Study

Lareyre, Fabien; Moratal, Claudine; Chikande, Julien; Jean-Baptiste, Elixène; Hassen-Khodja, Réda; Neels, Jaap G.; Chinetti-Gbaguidi, Giulia; Raffort, Juliette

doi:10.1177/1538574418784717

Cited by 6 publications

(10 citation statements)

References 34 publications

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“…Most of the studies published so far compared features between diabetic and non-diabetic patients with AAA ( 19 , 30 - 34 ). To the best of our knowledge, this is the first study addressing the association between insulin resistance and AAA.…”

Section: Discussionmentioning

confidence: 99%

“…This prospective monocentric cross-sectional study included patients with AAA eligible to surgical repair in the Department of Vascular Surgery at the University Hospital of Nice from January 2016 to February 2017. This study involves a previously published clinical cohort ( 19 ). It was conducted in conformity with the Declaration of Helsinki and was approved by our institutional local ethics committee (Comité de Protection des Personnes Sud Méditerranée V).…”

Section: Methodsmentioning

confidence: 99%

“…The pathophysiological mechanisms underlying the protective effect of diabetes on AAA occurrence and development are not totally understood and may be multifactorial through effects on ECM remodelling, inflammation, vascular smooth muscle cell homeostasis, neoangiogenesis, and thrombus formation ( 6 , 19 ). In addition, the use of antidiabetic drugs has also been paradoxically identified as a protective factor against AAA formation ( 20 , 21 ).…”

Section: Introductionmentioning

confidence: 99%

“…While the link between blood glucose concentration and AAA development is well described, the association between AAA and insulin resistance has never been explored. We previously published a pilot study which compared plasma inflammatory profile between diabetic and non-diabetic patients with AAA ( 19 ). However, we did not address the association between insulin resistance and AAA independently of diabetic status.…”

Section: Introductionmentioning

confidence: 99%

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Association of abdominal aortic aneurysm diameter with insulin resistance index

Lareyre¹,

Moratal

Zereg³

et al. 2018

Biochemia Medica

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IntroductionEpidemiological studies have highlighted a negative association between diabetes and abdominal aortic aneurysm (AAA). The aim of this study was to investigate the association between insulin resistance and AAA size.Materials and methodsThis prospective cross sectional monocentric study analysed fasting blood samples from 55 patients with AAA eligible for surgical repair. They were divided into 2 groups according to the median AAA diameter: diameter < 50 mm (N = 28) and diameter > 50 mm (N = 27). The median ages were respectively 73 years (62 - 79) and 72 years (67 - 81). Glucose and fructosamine concentrations were determined by spectrophotometry; insulin and C-peptide using chemiluminescent technology. Homeostasis model assessment 2 calculator was used to estimate insulin resistance index (HOMA2 IR).ResultsThere was no significant difference for fasting glucose concentration between the groups (6.1 vs. 5.9 mmol/L, P = 0.825). C-peptide and insulin concentrations, as well as HOMA2 IR index were significantly higher in patients with AAA > 50 mm (0.82 vs. 0.54 nmol/L, P = 0.012; 9 vs. 5 mU/L, P = 0.019 and 1.72 vs. 1.26, P = 0.028, respectively). No linear correlation was identified between AAA diameter and HOMA2 IR. Fructosamine concentration was lower in patients with AAA > 50 mm (225.5 vs. 251 μmol/L, P = 0.005) and negatively correlated with AAA diameter (r = - 0.54, P < 0.001).ConclusionThis study evidenced an association between AAA diameter and insulin resistance. Further studies are required to determine a causal link between insulin resistance and AAA development.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Association of abdominal aortic aneurysm diameter with insulin resistance index

Lareyre¹,

Moratal

Zereg³

et al. 2018

Biochemia Medica

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“…Human samples were obtained from patients with AAA and from organ donors at the University Hospital of Nice (Nice, France). This study involves partly a previously published clinical cohort (43,44) Animal studies.…”

Section: Human Samples Analysismentioning

confidence: 99%