Investigation of possible teratogenic effects in the offspring of mice exposed to methylphenidate during pregnancy

Costa, Gabriel de Araújo; Galvão, Talita Cristina; Bacchi, André Demambre; Moreira, Estefânia Gastaldello; Salles, Maria José Sparça

doi:10.1016/j.rbmo.2015.11.016

Cited by 18 publications

(3 citation statements)

References 35 publications

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“…During the GD 6–8 in mice the incomplete differentiation of trophoblastic cells results in an incomplete placental barrier. Therefore, maternal exposure to drugs or medications during this period may have teratogenic effects ( Costa et al, 2016 ). This is precisely why we utilized Rg1 during PND 1–9.…”

Section: Discussionmentioning

confidence: 99%

Protective role of the ginsenoside Rg1 against methimazole-induced gestational hypothyroidism on reflexive behaviors, conditioned fear and cortical antioxidant levels in mice offspring

Sanaiee,

Hassanpour,

Vazir

2024

IBRO Neuroscience Reports

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Section: Discussionmentioning

confidence: 99%

Protective role of the ginsenoside Rg1 against methimazole-induced gestational hypothyroidism on reflexive behaviors, conditioned fear and cortical antioxidant levels in mice offspring

Sanaiee,

Hassanpour,

Vazir

2024

IBRO Neuroscience Reports

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“…Thus, the chemicals can affect the fetus, the placenta, and even the mother herself [ 14 ]. Administration of chemical agents in the early embryonic period, since the trophoblast cell differentiation is not complete to make the placental membrane [ 43 ], can affect the development of embryonic tissue and the placenta [ 44 ].…”

Section: Discussionmentioning

confidence: 99%

Prenatal Developmental Toxicity and Histopathological Changes of the Placenta Induced by Syzygium guineense Leaf Extract in Rats

Abebe

Asres

Bekuretsion

et al. 2022

Journal of Toxicology

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Many of the traditional herbal products are served to the consumer without proper efficacy and safety investigations. A laboratory-based experimental study was employed to investigate the toxic effects of Syzygium guineense leaf extract on the fetal development and histopathology of the placenta in rats. Fifty pregnant Wistar albino rats were randomly allocated into five groups, each consisting of 10 rats. S. guineense leaf extract, at doses of 250, 500, and 1000 mg/kg of body weight, was respectively administered to groups I-III rats. Groups four and five were control and ad libitum control, respectively. The number of resorptions, implantation sites, and live or dead fetuses was counted. The weight and crown-rump length of the fetuses were measured. The histopathological investigation of the placenta was conducted. Administration of 70% ethanol extract of S. guineense leaves reduced weight gain and food intake of pregnant rats at p value <0.05. The crown-rump length of the near-term rat fetus was significantly reduced in rats treated with 1000 mg/kg body weight of S. guineense extract ( p value <0.05). The plant extract did not affect the number of implantations, fetal resorptions, live births, and stillbirths. The weight of the fetuses and the placentae also decreased dose-dependently. Decidual cystic degeneration was the most prevalent histopathological change observed in a rat’s placenta treated with 1000 mg/kg body weight of S. guineense extract. Consumption of S. guineense leaves, especially at a high dose, may affect fetal development. Therefore, liberal use of S. guineense leaves during pregnancy should be avoided.

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“…However, our subgroup analysis suggested that there might be a small increase in the risk of cardiovascular malformations associated with intrauterine exposure to MPH. Although very high doses of MPH have also been associated with certain malformations, most animal studies using relevant doses have not indicated a teratogenic effect . It should be noted that cardiovascular malformations might be associated with coexisting mental disorders and other associated factors rather than with exposure to MPH .…”

Section: Discussionmentioning

confidence: 99%

Maternal and neonatal outcomes after exposure to ADHD medication during pregnancy: A systematic review and meta‐analysis

Jiang

Zhang

Jiang

et al. 2018

Pharmacoepidemiology and Drug

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Purpose Attention‐deficit/hyperactivity disorder (ADHD) medications are used by increasing numbers of reproductive‐age women. The safety of these medications during pregnancy has not been well described. Methods A systematic review and meta‐analysis was performed to evaluate the adverse maternal and neonatal outcomes associated with exposure to ADHD medication during pregnancy. The PubMed and Embase databases were searched to identify potential studies for inclusion. Results Eight cohort studies that estimated adverse maternal or neonatal outcomes associated with exposure to ADHD medication during pregnancy were included. Exposure to ADHD medication was associated with an increased risk of neonatal intensive care unit (NICU) admission compared with no exposure at any time (risk ratio (RR) 1.88; 95% confidence interval (CI), 1.7‐2.08) and compared with women with exposure either before or after pregnancy (RR 1.38; 95% CI, 1.23‐1.54; P < 0.001). Exposure to methylphenidate (MPH) was marginally associated with an increased risk for cardiac malformation (RR 1.27; 95% CI, 0.99‐1.63; P = 0.065) compared with no exposure. However, exposure to ADHD medication was not associated with an increased risk for other adverse maternal or neonatal outcomes. This analysis was limited by the small number of studies included and the limited adjustments for the possible confounders in the studies. Conclusions Exposure to ADHD medication during pregnancy does not appear to be associated with adverse maternal or neonatal outcomes. Given the few studies included, further larger, prospective studies that control for important confounders are needed to verify our findings.

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Investigation of possible teratogenic effects in the offspring of mice exposed to methylphenidate during pregnancy

Cited by 18 publications

References 35 publications

Protective role of the ginsenoside Rg1 against methimazole-induced gestational hypothyroidism on reflexive behaviors, conditioned fear and cortical antioxidant levels in mice offspring

Protective role of the ginsenoside Rg1 against methimazole-induced gestational hypothyroidism on reflexive behaviors, conditioned fear and cortical antioxidant levels in mice offspring

Prenatal Developmental Toxicity and Histopathological Changes of the Placenta Induced by Syzygium guineense Leaf Extract in Rats

Maternal and neonatal outcomes after exposure to ADHD medication during pregnancy: A systematic review and meta‐analysis

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