Investigation of potential genomic biomarkers for obesity and personalized medicine

Ergören, Mahmut Çerkez; Söyler, Gizem; Sah, Huseyin; Becer, Eda

doi:10.1016/j.ijbiomac.2018.10.059

Cited by 12 publications

(5 citation statements)

References 48 publications

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“…Based on these findings, it is reasonable to assume that ACE I/D polymorphism is important in the development of obesity among the Saudi population. However, the published literature on ACE DD polymorphism on obese patients from different geographically distributed populations reveals both negative associations 21–23 and positive associations. 20,24–26 The results from a meta-analysis of ACE I/D polymorphism showed the positive contribution of D allele towards the risk of developing metabolic syndrome, a disorder closely related to central obesity.…”

Section: Discussionmentioning

confidence: 98%

ACE insertion/deletion genetic polymorphism, serum ACE levels and high dietary salt intake influence the risk of obesity development among the Saudi adult population

Sabir

Omri

Khan

et al. 2019

J Renin Angiotensin Aldosterone Syst

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Introduction: Angiotensin-converting enzyme ( ACE), which contributes to adipocyte growth, differentiation and function, has recently been linked with both salt metabolism and obesity development. Therefore, this study has aimed to investigate the putative relationship between ACE genetic polymorphism, serum ACE levels and salt consumption on the risk of developing obesity in the Saudi population. Materials and methods: ACE genotype status of 267 adult Saudi volunteers (124 obese and 143 non-obese) was correlated with their serum ACE activity and dietary salt intake amounts. Results: Obesity was more prevalent in deletion-deletion genotype individuals ( p<0.03), under dominant, co-dominant and monoallelic conditions ( p<0.04). Deletion allele corresponds to serum ACE activity in obese patients ( p<0.05). The amount of salt intake (<6 g/d) was significantly associated with obesity and particularly high in deletion-deletion and insertion-deletion genotype carriers ( p<0.001). STITCH analysis underlined interactions of the ACE protein with sodium molecule, REN, ACE2, KNG1 and AGTR1 in a biological network. Conclusions: Our findings suggest the positive association between ACE deletion genotype, serum ACE activity and sodium intake with risk of obesity development in the Saudi population.

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Section: Discussionmentioning

confidence: 98%

ACE insertion/deletion genetic polymorphism, serum ACE levels and high dietary salt intake influence the risk of obesity development among the Saudi adult population

Sabir

Omri

Khan

et al. 2019

J Renin Angiotensin Aldosterone Syst

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“…However, the predisposition effect of these gene loci show differences according to the interaction with environment as well as ethnic origin. Recently, we investigated the relationship between FTO rs9939609 (A>T), ADIPOQ rs2241766 (G>T), and ACE rs4340288 polymorphism and obesity in the current population [ 25 ] and our results indicated that the FTO gene rs9939609 A allele was found to have a strong association with pathogenesis obesity in Turkish-Cypriots. Additionally, Becer et al .…”

Section: Discussionmentioning

confidence: 99%

“…Recently, we have investigated the association between the Adiponectin (ADIPOQ) , the fat mass and obesity-associated (FTO) and the angiotensin I-converting (ACE) genes variants and obesity [ 25 ]. There is no investigative study showing the relationship between the GHRL gene polymorphisms and obesity in North Cyprus.…”

Section: Introductionmentioning

confidence: 99%

Dual effect of the GHRL gene variant in the molecular pathogenesis of obesity

Becer

Ergoren

2021

Balkan Journal of Medical Genetics

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Obesity is as a global health problem due to its interaction with complex chronic disorders such as cardiovascular disorders, type 2 diabetes mellitus (T2DM) and cancer. Despite the fact that pathogenesis of obesity is not yet clearly understood, it is associated with a combination of psychological, environmental and various genetic factors. Here, employing a case-control design, we aimed to examine the effects of the GHRL c.152C>T (p.Arg51Gln) (rs34911341) and c.214G>T (p.Leu72Met) (rs696217) markers on susceptibility to obesity in a Turkish-Cypriot population, as well as to evaluate whether these markers affect biochemical parameters and show their putative functional consequences. This study involved 211 Turkish-Cypriot subjects (106 obese and 95 non obese). Genotyping for the GHRL gene polymorphisms was performed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis. Our results indicate that the GHRL Leu72Met polymorphism was found to be significantly higher in obese patients, with respect to genotypic (p = 0.0012) and allelic (p = 0.0005) frequencies. Strikingly, the rs696217 GT genotype (heterozygous) had significantly lower serum high-density lipoprotein cholesterol (HDL-C) (p = 0.015) than GG (wild type) genotypes. Overall, Leu72Met susceptibility variant may be considered as risk and crucial marker for both obesity and cholesterol metabolism in the community of Turkish-Cypriots. Thus, the dual effect of the GHRL gene Leu72Met variant may be used for clinical diagnosis.

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“…Adiponectin has been demonstrated to predict obesity and metabolic health status among adult populations, and is a potential target for personalized medical therapy, as adiponectin may contribute to obesity and diabetes to varying degrees between and within populations [ 18 ]. The Hispanic population represents a historically underrepresented group in academic medicine, making them an important target of additional research in the potential rise in personalized medicine [ 19 ].…”

Section: Introductionmentioning

confidence: 99%

Inflammatory markers and body mass index amoung hispanic children

Lang,

Loudermilk,

Clark

et al. 2024

PLoS ONE

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Background and objectives Body mass index (BMI) is inversely proportional with adiponectin levels among adults, while insulin, C-reactive protein (CRP), interleukin 6 (IL-6), resistin and tumor necrosis factor-alpha (TNF-α) have been linked with elevated BMI. The role and relation of these biomarkers with BMI among a Hispanic pediatric population are less known. Thus, the objective of this study was to examine the association of inflammatory markers with the odds of overweight/obesity while controlling for several sociodemographic factors among a Hispanic youth population in Northeast Tennessee. Methods Height, weight, demographic information, and blood samples were collected from 107 Hispanic children aged 2 to 10 years recruited at a large community health center in 2015–2016 in Northeast Tennessee. Data for this research were accessed and analyzed in 2022. Multivariable logistic regression was conducted to assess the relations between adiponectin, insulin, resistin, CRP, TNF-α, and IL-6, and overweight/obesity vs. having a healthy (normal) weight. Results Adiponectin levels were significantly lower among overweight/obese Hispanic children (p = 0.0144) compared to healthy weight children. The odds of overweight/obesity decreased by 4% for every one-unit increase in serum adiponectin. Insulin levels were significantly higher among overweight/obese Hispanic children compared to healthy weight children (p = 0.0048). The odds of overweight/obesity increased by 7% for every one-unit increase in serum insulin. Resistin, IL-6, TNF-α, and CRP were not significantly associated with overweight/obesity in this population. Conclusion Adiponectin behaves similarly in Hispanic youth as it does in other pediatric populations, possibly making it a valuable marker when examining metabolic health status in this population.

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Investigation of potential genomic biomarkers for obesity and personalized medicine

Cited by 12 publications

References 48 publications

ACE insertion/deletion genetic polymorphism, serum ACE levels and high dietary salt intake influence the risk of obesity development among the Saudi adult population

ACE insertion/deletion genetic polymorphism, serum ACE levels and high dietary salt intake influence the risk of obesity development among the Saudi adult population

Dual effect of the GHRL gene variant in the molecular pathogenesis of obesity

Inflammatory markers and body mass index amoung hispanic children

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