Investigation of proton spin relaxation in water with dispersed silicon nanoparticles for potential magnetic resonance imaging applications

Kargina, Yu. V.; Gongalsky, M. B.; Perepukhov, Alexander M.; Gippius, A. A.; Миннеханов, А. А.; Zvereva, E.A.; Maximychev, Alexander V.; Timoshenko, V. Yu.

doi:10.1063/1.5006846

Cited by 11 publications

(17 citation statements)

References 37 publications

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“…The latter is obviously related to aggregates of the NPs. Zeta potentials of SIO NPs in aqueous suspensions for all samples is around −20 ± 5 mV, which is typical for Si based NPs …”

Section: Resultsmentioning

confidence: 70%

“…The latter value is higher than that for clinically used CAs based on SPIO NPs . The higher relaxivity of SIO NPs can be explained by the contributions of both the iron ions and intrinsic paramagnetic centers (Si dangling bonds) …”

Section: Resultsmentioning

confidence: 83%

“…The shortening effect is maximal for the transverse magnetization measurements. To characterize the shortening efficiency one can use the longitudinal and transverse relaxivity, which can be defined as follows

r_{1, 2} = R_{1, 2} / C_{N P}

where R 1,2 is the corresponding relaxation rate defined as

R_{1, 2} = 1 / T_{1, 2} - 1 / T_{1, 2}^{w}

where C NP is the concentration of SIO NPs, T 1,2 and T 1,2 w are the relaxation times of SIO NP suspensions and pure water, respectively.…”

Section: Resultsmentioning

confidence: 99%

“…Silicon (Si) NPs are biocompatible and, unlike previous NPs, they can excrete from the body by biodegradation into orthosilicic acid . It was shown that Si NPs can be used as agents for MRI visualization of the tumors, as active agents for mild cancer therapy …”

Section: Introductionmentioning

confidence: 99%

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Silicon Nanoparticles Prepared by Plasma‐Assisted Ablative Synthesis: Physical Properties and Potential Biomedical Applications

Kargina

Perepukhov

Kharin

et al. 2019

Physica Status Solidi (a)

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Silicon (Si) nanoparticles (NPs) with small (10 À3 -10 À1 at%) content of iron oxide (Fe 2 O 3 ) are prepared by plasma-assisted ablative synthesis. Powders of the prepared Si-iron oxide (SIO) NPs are investigated by means of the transmission electron microscopy, Raman spectroscopy, electron paramagnetic resonance, and magnetic susceptibility measurements. Aqueous suspensions of the NPs are studied by using dynamic light scattering and nuclear magnetic resonance technique. The longitudinal and transverse relaxation times of protons in aqueous suspensions of the NPs are found to be dependent on the iron content. The stronger decrease of the proton relaxation is detected for the samples with higher iron content. Magnetic resonance imaging (MRI) experiments show that SIO NPs have properties of the MRI contrast agent and it is confirmed by in vivo experiments with cancer tumor. Aqueous suspensions of SIO NPs are explored as sensitizers of electromagnetic radio frequency hyperthermia and the highest heating rate is observed for the NPs with smaller hydrodynamic size (%50 nm). The obtained results indicate possible ways for applications of SIO NPs in the MRI diagnostics and mild therapy of cancer.

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“…The latter is obviously related to aggregates of the NPs. Zeta potentials of SIO NPs in aqueous suspensions for all samples is around −20 ± 5 mV, which is typical for Si based NPs …”

Section: Resultsmentioning

confidence: 70%

Section: Resultsmentioning

confidence: 83%

r_{1, 2} = R_{1, 2} / C_{N P}

where R 1,2 is the corresponding relaxation rate defined as

R_{1, 2} = 1 / T_{1, 2} - 1 / T_{1, 2}^{w}

where C NP is the concentration of SIO NPs, T 1,2 and T 1,2 w are the relaxation times of SIO NP suspensions and pure water, respectively.…”

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Silicon Nanoparticles Prepared by Plasma‐Assisted Ablative Synthesis: Physical Properties and Potential Biomedical Applications

Kargina

Perepukhov

Kharin

et al. 2019

Physica Status Solidi (a)

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show abstract

“…Si NPs with a high number of the electron spin centers can act as contrast agents (CAs) for the conventional biomedical MRI at the proton ( 1 H) frequency [95]. The MRI contrast property of Si NPs was explained by considering the magnetic dipole-dipole interaction between electron spins on the Si NP's surfaces and those of surrounding protons [96] as schematically shown in Figure 36. While a solid NP itself can increase the proton spin relaxation (Figure 36a), Si NPs especially prepared from por-Si provide additional opportunities to increase the spin center density due to huge specific surface area of small nc-Si [62].…”

Section: Si Nps With Electron Spin Centers As Potential Contrast Agenmentioning

confidence: 99%

Spin-Dependent Phenomena in Semiconductor Micro-and Nanoparticles—From Fundamentals to Applications

Fomin

Timoshenko

2020

Applied Sciences

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The present overview of spin-dependent phenomena in nonmagnetic semiconductor microparticles (MPs) and nanoparticles (NPs) with interacting nuclear and electron spins is aimed at covering a gap between the basic properties of spin behavior in solid-state systems and a tremendous growth of the experimental results on biomedical applications of those particles. The first part of the review represents modern achievements of spin-dependent phenomena in the bulk semiconductors from the theory of optical spin orientation under indirect optical injection of carriers and spins in the bulk crystalline silicon (c-Si)—via numerous insightful findings in the realm of characterization and control through the spin polarization—to the design and verification of nuclear spin hyperpolarization in semiconductor MPs and NPs for magnetic resonance imaging (MRI) diagnostics. The second part of the review is focused on the electron spin-dependent phenomena in Si-based nanostructures, including the photosensitized generation of singlet oxygen in porous Si and design of Si NPs with unpaired electron spins as prospective contrast agents in MRI. The experimental results are analyzed by considering both the quantum mechanical approach and several phenomenological models for the spin behavior in semiconductor/molecular systems. Advancements and perspectives of the biomedical applications of spin-dependent properties of Si NPs for diagnostics and therapy of cancer are discussed.

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Recent Developments in Porous Silicon Nanovectors with Various Imaging Modalities in the Framework of Theranostics

et al. 2022

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The number of in vitro, ex vivo, and in vivo studies on porous silicon (PSi) nanoparticles for biomedical applications has increased extensively over the last decade. The focus of the reports has been on the carrier properties of PSi concerning the therapeutic aspect due to several beneficial nanovector characteristics including high payload capacity, biocompatibility, and versatile surface chemistry. Recently, increasing attention has been paid to the diagnostic aspects of PSi, which is typically attributed to the biotraceability of the nanovector. Also, PSi has been studied as a contrast agent. When both these aspects, therapy and diagnosis, are integrated into one nanovector, we can discuss a real nanotheranostics approach. Herein, we review the recent progress developing PSi for various imaging modalities, specifically focusing on optical imaging, magnetic resonance imaging, and nuclear medicine imaging. Furthermore, we summarized the knowledge gaps that must be covered before applying PSi in clinical imaging, highlighting future research trends.

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Investigation of proton spin relaxation in water with dispersed silicon nanoparticles for potential magnetic resonance imaging applications

Cited by 11 publications

References 37 publications

Silicon Nanoparticles Prepared by Plasma‐Assisted Ablative Synthesis: Physical Properties and Potential Biomedical Applications

Silicon Nanoparticles Prepared by Plasma‐Assisted Ablative Synthesis: Physical Properties and Potential Biomedical Applications

Spin-Dependent Phenomena in Semiconductor Micro-and Nanoparticles—From Fundamentals to Applications

Recent Developments in Porous Silicon Nanovectors with Various Imaging Modalities in the Framework of Theranostics

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