2014
DOI: 10.1117/1.jbo.19.9.097001
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Investigation of reflectance sampling depth in biological tissues for various common illumination/collection configurations

Abstract: Knowledge of light penetration characteristics is very important in almost all studies in biomedical optics. In this work, the reflectance sampling depth in biological tissues was investigated using Monte Carlo simulations for various common illumination/collection configurations. The analysis shows that the average sampling depth can be described by two simple empirical analytical expressions over the entire typical ranges of absorption and scattering properties relevant to in vivo biological tissue, regardle… Show more

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Cited by 10 publications
(8 citation statements)
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“…The penetration depth of photons migrating in random media has been studied by several research groups2425262728293031323334353637. The mean average depth or the mean maximum depth 〈 z max 〉 reached by photons eventually detected at the surface of the medium at a distance ρ from the injection point are the main quantities investigated (also indicated as and 〈 z max | ρ 〉).…”
mentioning
confidence: 99%
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“…The penetration depth of photons migrating in random media has been studied by several research groups2425262728293031323334353637. The mean average depth or the mean maximum depth 〈 z max 〉 reached by photons eventually detected at the surface of the medium at a distance ρ from the injection point are the main quantities investigated (also indicated as and 〈 z max | ρ 〉).…”
mentioning
confidence: 99%
“…Zonios 37 studied the penetration depth at short inter-optodes distances by means of MC simulations in the CW domain for a semi-infinite medium. For the total CW reflectance Zonios provided also an empirical analytical expression for derived from MC simulations that shows to be valid even for large values of the reduced scattering coefficient, , and the absorption coefficient, μ a , of the medium.…”
mentioning
confidence: 99%
“…Similarly, the physics of optics in random media 3,18,19 , and the attempts to improve focusing through scattering media need to model the depth profile of re-emitted photons [20][21][22][23] . The penetration depth of photons migrating in random media has been studied by several research groups [24][25][26][27][28][29][30][31][32][33][34][35][36][37] . The mean average depth z or the mean maximum depth 〈 z max 〉 reached by photons eventually detected at the surface of the medium at a distance ρ from the injection point are the main quantities investigated (also indicated as ρ z and 〈 z max |ρ〉 ).…”
mentioning
confidence: 99%
“…Zonios 37 studied the penetration depth at short inter-optodes distances by means of MC simulations in the CW domain for a semi-infinite medium. For the total CW reflectance Zonios provided also an empirical analytical expression for z derived from MC simulations that shows to be valid even for large values of the reduced scattering coefficient, µ′ s , and the absorption coefficient, μ a , of the medium.…”
mentioning
confidence: 99%
“…media has been largely investigated in the time-domain (TD) and in the continuous wave (CW) domain by several research groups [1][2][3][4][5][6][7][8][9][10]. Recently, the photon penetration depth for a slab, in TD and CW domain, has been studied by means of a comprehensive statistical approach.…”
mentioning
confidence: 99%