Investigation of Saccadic Eye Movement Effects on the Fluid Dynamic in the Anterior Chamber

Abstract

<jats:p>The aqueous humor (AH) flow in the anterior chamber (AC) due to saccadic movements is investigated in this research. The continuity, Navier-Stokes and energy equations in 3D and unsteady forms are solved numerically and the saccadic motion was modeled by the dynamic mesh technique. Firstly, the numerical model was validated for the saccadic movement of a spherical cavity with analytic solutions and experimental data where excellent agreement was observed. Then, two types of periodic and realistic saccadic motions of the AC are simulated, whereby the flow field is computed for various saccade amplitudes and the results are reported for different times. The results show that the acting shear stress on the corneal endothelial cells from AH due to saccadic movements is much higher than that due to normal AH flow by buoyancy induced due to temperature gradient. This shear stress is higher on the central region of the cornea. The results also depict that eye saccade imposes a 3D complicated flow field in the AC consist of various vortex structures. Finally, the enchantment of heat transfer in the AC by AH mixing as a result of saccadic motion is investigated.</jats:p>

Phakic Iris-Fixated Intraocular Lens Placement in the Anterior Chamber: Effects on Aqueous Flow

“…4 of that paper, red line). We also note that the WSS distribution on the cornea is not significantly modified by the presence of the pIOL, and it is in agreement with the distribution shown by Abouali et al 23 (see fig. 3 of that paper).…”

“…11b) in the absence (open circles) and presence (solid circles) of the pIOL. The time evolution of the WSS on the cornea with no pIOL agrees closely (both qualitatively and quantitatively) with that obtained numerically by Abouali et al 23 (see fig. 4 of that paper, red line).…”

Numerical Simulation of Aqueous Flow in Laser Iridotomy

“…For a long time, the numerical study on the factors affecting the flow of aqueous humor has focused on three aspects: (1) Analysis of the flow mechanism of aqueous humor: The aqueous humor (AH) flow in the anterior chamber (AC) due to saccadic movements is investigated by Abouali, et al [4] . Ooi [5] proposed various hypotheses to describe the cause of the aqueous humor flow.…”

A Mathematical Model of Corneal Metabolism in the Presence of an Iris-Fixated Phakic Intraocular Lens

“…10 This flow also exists with a similar intensity in the presence of a PIOL. 4,11 Moreover, daytime eye rotations also generate significant velocities and mixing in the aqueous. 11,12 Thus, in this case the presence of the PIOL is not likely to interfere much with nutrient transport to the cornea.…”

“…4,11 Moreover, daytime eye rotations also generate significant velocities and mixing in the aqueous. 11,12 Thus, in this case the presence of the PIOL is not likely to interfere much with nutrient transport to the cornea. On the other hand, during sleep the eyelids are closed and, when rapid eye movements (REMs) do not occur, the eye globe is approximately fixed.…”