Investigation of seasonal variability of vestibular neuronitis

Koors, Paul D.; Thacker, Leroy R.; Coelho, Daniel H.

doi:10.1017/s0022215113001977

Cited by 17 publications

(28 citation statements)

References 26 publications

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“…[3,[5][6][7]9] Although Dix and Hallpike suggested a possibility of infection of Scarpa ganglion or the vestibular nerve, it was not verified whether direct viral infection of the vestibular organ could induce VN. [4,6] An animal model of VN was developed by inoculating herpes simplex virus (HSV) type 1 into the auricle of mice, and HSV type 1 deoxynucleic acid was detected by polymerase chain reaction in about 60 percent of autopsied vestibular ganglia in human. [3,[5][6][7]9] Thus, reactivation of latent viruses, such as HSV type 1, was thought to be associated with VN.…”

Section: Discussionmentioning

confidence: 99%

“…[4,6] An animal model of VN was developed by inoculating herpes simplex virus (HSV) type 1 into the auricle of mice, and HSV type 1 deoxynucleic acid was detected by polymerase chain reaction in about 60 percent of autopsied vestibular ganglia in human. [3,[5][6][7]9] Thus, reactivation of latent viruses, such as HSV type 1, was thought to be associated with VN. [2,3,[5][6][7]9,10] A viral etiology had been supported previously by the following findings.…”

Section: Discussionmentioning

confidence: 99%

“…[ 12 ] Because the incidence of viral infections varies by season, seasonal variations in VN could support this viral hypothesis. [ 6 ]…”

Section: Introductionmentioning

confidence: 99%

“…In a study with 52 patients with VN for 3 years in the United States, there were no significant annual or seasonal variations. [ 6 ] In a prospective, population-based study with 79 patients with VN for 2 years in Croatia, there was also no seasonal variation. [ 8 ] In a study using a nationwide database with 6108 patients with VN for 3 years in Germany, no seasonal variation was demonstrated.…”

Section: Introductionmentioning

confidence: 99%

“…Vascular ischemia and autoimmune reaction are additional possible causes of VN. [5][6][7]10,14] Thus, multiple etiologies could influence the incidence of VN. In the present study, we analyzed many patients with VN over a several-year period to evaluate monthly and seasonal variations.…”

Section: Introductionmentioning

confidence: 99%

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Monthly and seasonal variations in vestibular neuritis

Jeong

Nam²,

Oh³

et al. 2022

Medicine

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Seasonal variations in vestibular neuritis (VN) could support the etiology of viral infection. However, several recent studies revealed no significant seasonal variations in VN. Further studies are necessary to determine the etiology of VN. We analyzed patients with VN to evaluate monthly and seasonal variations. Patients with VN who visited our otorhinolaryngology department or were referred to our department from the emergency department between March 2014 and February 2019 were included retrospectively in this study. Differences among the months and seasons of VN visits were analyzed. Patients were divided into 2 groups according to sex and age (65 years or older and younger than 65 years). Differences among the months and seasons of VN visits were analyzed between groups. There were no significant differences in monthly and seasonal distributions in 248 patients with VN. There were also no significant differences in monthly and seasonal distributions in male and female patients or in older and younger patients. There were no significant differences in monthly or seasonal distributions of patients with VN. Factors other than viruses, such as vascular ischemia, should also be considered in the incidence of VN, especially in older patients.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

“…[ 12 ] Because the incidence of viral infections varies by season, seasonal variations in VN could support this viral hypothesis. [ 6 ]…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Monthly and seasonal variations in vestibular neuritis

Jeong

Nam²,

Oh³

et al. 2022

Medicine

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Seasonal variation in peripheral vestibular disorders based on Korean population data

Jeong,

Youk,

Jung

et al. 2024

Laryngoscope Investig Oto

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ObjectivesComprehensive studies in which the seasonal variation in peripheral vestibular disorders was evaluated using data from an entire population are insufficient. The seasonal variation in peripheral vestibular disorders based on data from the entire Korean population was investigated in the present study.MethodsRetrospective data from the National Health Insurance Service of Korea from 2008 to 2020 was analyzed. Benign paroxysmal positional vertigo (BPPV), vestibular neuritis (VN), and Meniere's disease (MD) were defined based on diagnostic, treatment, or audiovestibular test codes. The seasonal incidence for each peripheral vestibular disorder was calculated among all study subjects.ResultsFor the entire study cohort, the incidence of BPPV was significantly higher in spring (odds ratio [OR] = 1.031, 95% confidence interval [CI] = 1.026–1.037), autumn (OR = 1.024, 95% CI = 1.019–1.029), and winter (OR = 1.051, 95% CI = 1.046–1.056) than in summer. The incidence of VN was significantly lower in winter (OR = 0.917, 95% CI = 0.907–0.927) than in summer. The incidence of MD was significantly higher in spring (OR = 1.027, 95% CI = 1.015–1.039) and autumn (OR = 1.029, 95% CI = 1.017–1.041) and significantly lower in winter (OR = 0.919, 95% CI = 0.908–0.931) than in summer. Differences were also observed in seasonal variation based on sex and age.ConclusionsSignificant seasonal variation occurred in peripheral vestibular disorders including BPPV, VN, and MD based on the entire Korean population data. Furthermore, seasonal variation showed differences based on sex and age.Level of Evidence4.

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