Investigation of serum and brain superoxide dismutase levels depending on atomoxetine used in attention-deficit/hyperactivity disorder treatment: A combination of in vivo and molecular docking studies

Gür, Fatma; Gür, Bahri; Erkayman, Beyzagül; Halıcı, Zekai; Karakoc, Akar

doi:10.1016/j.bioorg.2020.104435

Cited by 19 publications

(5 citation statements)

References 46 publications

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“…ROS is a normal metabolite that plays an important role in cell signaling pathways [ 43 ]. However, excessive ROS can lead to oxidative damage in the human body and food system by reacting with biomolecules, such as DNA, lipids, proteins, and sugars, and destroying their structures and functions [ 44 ].…”

Section: Resultsmentioning

confidence: 99%

Enzymatic Degradation of Gracilariopsis lemaneiformis Polysaccharide and the Antioxidant Activity of Its Degradation Products

Tian

Zhang

et al. 2021

Marine Drugs

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Gracilariopsis lemaneiformis polysaccharides (GLP) were degraded using pectinase, glucoamylase, cellulase, xylanase, and β-dextranase into low-molecular-weight polysaccharides, namely, GPP, GGP, GCP, GXP, and GDP, respectively, and their antioxidant capacities were investigated. The degraded GLPs showed higher antioxidant activities than natural GLP, and GDP exhibited the highest antioxidant activity. After the optimization of degradation conditions through single-factor and orthogonal optimization experiments, four polysaccharide fractions (GDP1, GDP2, GDP3, and GDP4) with high antioxidant abilities (hydroxyl radical scavenging activity, DPPH radical scavenging activity, reduction capacity, and total antioxidant capacity) were obtained. Their cytoprotective activities against H2O2-induced oxidative damage in human fetal lung fibroblast 1 (HFL1) cells were examined. Results suggested that GDP pretreatment can significantly improve cell viability, reduce reactive oxygen species and malonaldehyde levels, improve antioxidant enzyme activity and mitochondria membrane potential, and alleviate oxidative damage in HFL1 cells. Thus, the enzyme degradation of GLP with β-dextranase can significantly improve its antioxidant activity, and GDP might be a suitable source of natural antioxidants.

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Section: Resultsmentioning

confidence: 99%

Enzymatic Degradation of Gracilariopsis lemaneiformis Polysaccharide and the Antioxidant Activity of Its Degradation Products

Tian

Zhang

et al. 2021

Marine Drugs

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show abstract

“…[20,25,26]. Enerji minimizasyonu ve diğer parametreler önceki çalışmalarımızda yapıldığı gibi ayarlandı [27,28].…”

Section: Hyperoside'nin Siklofosfamid Kaynaklı Apoptoza Karşı Koruyuc...unclassified

Hyperoside'nin siklofosfamid kaynaklı apoptoza karşı koruyucu etkilerinin in silico değerlendirilmesi

2023

Proceeding Book of 3rd International Conference on Scientific and Academic Research ICSAR 2023

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“…[30] The SOD is closely related to oxidative stress, which is effectively resisted when the activity of SOD is increased. [31] In addition, Xiao-Ke-An can decrease the apoptosis of islet β cells and increase insulin secretion by inhibiting the expression of caspase-3, a proteinase that mediates β-cell apoptosis. [32] Although several components of Xiao-Ke-An have shown DPP-4 activity, systematic screening of all its possible components relative to DPP-4 activity has not been studied thus far, and their binding modes between the active components and DPP-4 remain unclear.…”

Section: Introductionmentioning

confidence: 99%

“…The TNF‐α is strongly induced usually after tissue infection or injury; therefore, inhibiting its activity can effectively promote the regression of infection and tissue repair [30] . The SOD is closely related to oxidative stress, which is effectively resisted when the activity of SOD is increased [31] . In addition, Xiao‐Ke‐An can decrease the apoptosis of islet β cells and increase insulin secretion by inhibiting the expression of caspase‐3, a proteinase that mediates β‐cell apoptosis [32]…”

Section: Introductionmentioning

confidence: 99%

Exploring the Hypoglycaemic Mechanism of Chinese Medicine Xiao‐Ke‐An Based on Target Dipeptidyl Peptidase 4 Using Molecular Docking and Dynamics Simulation

et al. 2021

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Xiao-Ke-An is a traditional Chinese medicine formula for reducing the effects of diabetes by inhibiting dipeptidyl peptidase-4 (DPP-4) activity. However, its molecular mechanism is unclear owing to the complexity of its components. In this study, methods of molecular docking, molecular dynamics and molecular mechanics/Poisson Boltzmann surface area are combined for analysis. The main hypoglycaemic mechanism of Xiao-Ke-An involves multiple components. In particular, MOL003714 shows the strongest binding capacity with a binding free energy of À 253.08 kJ mol À 1 and thus could be a potent inhibitor of DPP-4. Additionally, MOL007062 and MOL010404 show strong interactions with superoxide dismutase, tumour necrosis factor-alpha and caspase-3, indicating their ability to decrease the symptoms of type II diabetes by alleviating insulin resistance and reducing inflammatory reactions and oxidative stress. This study provides a theoretical basis for the discovery and modification of natural DPP-4 inhibitors and details the role of Xiao-Ke-An.

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Investigation of serum and brain superoxide dismutase levels depending on atomoxetine used in attention-deficit/hyperactivity disorder treatment: A combination of in vivo and molecular docking studies

Cited by 19 publications

References 46 publications

Enzymatic Degradation of Gracilariopsis lemaneiformis Polysaccharide and the Antioxidant Activity of Its Degradation Products

Enzymatic Degradation of Gracilariopsis lemaneiformis Polysaccharide and the Antioxidant Activity of Its Degradation Products

Hyperoside'nin siklofosfamid kaynaklı apoptoza karşı koruyucu etkilerinin in silico değerlendirilmesi

Exploring the Hypoglycaemic Mechanism of Chinese Medicine Xiao‐Ke‐An Based on Target Dipeptidyl Peptidase 4 Using Molecular Docking and Dynamics Simulation

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