Investigation of serum neprilysin levels in overweight and normal weight young women

Abstract

Background In this study we aimed to evaluate biochemical, lipid and glycemic parameters and to compare serum neprilysin levels between overweight (OW) and normal weight (NW) young women who are more prone to gain weight. Material and Methods A total of 28 overweight/obese women aged between 22-34 years and 34 age matched normal-weight women were included in this cross-sectional study on voluntary basis. of the subjects were performed, Participants' anthropometric measurements, hormone profiles, glycemic parameters and insulin resistance, and serum neprilysin levels were recorded and analyzed. Patients were evaluated in two groups as Group OW and Group NW. Results The mean ALT, TSH and uric acid values were statistically significantly higher in Group OW compared to Group NW (for all, p<0.05). The mean HDL-c was statistically significantly lower in Group OW than in Group NW (p<0.01), while the mean triglyceride level was significantly higher in Group OW than in Group NW (p=0.002). The mean fasting blood glucose, insulin, HOMA, HbA1c and triglyceride values were statistically significantly higher in Group OW compared to Group NW (for all, p<0.001). The mean neprilysin (NEP) value was found as 1123.44±1327.60 mmol/L in Group NW and 1229.39±1315.17 mmol/L in Group OW with no statistically significant difference between the groups. No significant correlation was found between NEP and BMI values. Conclusions In this study, no significant difference was found between serum neprilysin levels of overweight/obese and normal weight women, suggesting that neprilysin does not play a role in the pathogenesis of obesity, insulin resistance or diabetes.