Investigation of serum vitamin D levels in Chinese infertile men

Zhu, Chunxia; Xu, Qin; Li, S.-x.; Wei, Yarong; Zhu, Guoxing; Yang, Cui; Shi, Yun

doi:10.1111/and.12570

Cited by 36 publications

(42 citation statements)

References 16 publications

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“…Prolactin receptors have been found in Leydig and Sertoli cells in male testes, and high serum PRL levels reduce spermatogenesis, sperm motility and quality by reducing the pulsatile release of FSH, LH and testosterone (Blomberg et al, ; Boisen et al, ; Zhu et al, ). In our study, serum PRL levels were significantly elevated in the infertile groups than in the fertile group.…”

Section: Discussionmentioning

confidence: 90%

“…Follicle‐stimulating hormone and luteinising hormone are essential for normal spermatogenesis in men. It has been shown that serum FSH and LH levels increase in cases of spermatogenesis slowing down, decreased TPMSC and azoospermia (Chen, Hsieh, Yu, & Chang, ; Inal, Kahyaoglu, Turkkani, Tuzluoglu, & Yilmaz, ; Zhu et al, ). In our study, in line with previous studies, serum FSH and LH levels were significantly higher in men with oligospermia and azoospermia than in fertile men.…”

Section: Discussionmentioning

confidence: 99%

“…Although there was a difference in serum vitamin D levels among the groups in our study, no difference was observed in terms of serum PTH levels. It has been posited that vitamin D increases sperm motility by increasing intracellular calcium concentration in the male reproductive system's spermatogenesis and has a positive effect on acrosome reaction, enhancing sperm fertilisation ability (Blomberg et al, 2016;Lerchbaum & Obermayer-Pietsch, 2012;Zhu et al, 2016). Some studies have shown an association and positive correlation between serum 25-OH VD levels and sperm parameters, especially sperm motility (Blomberg et al, 2016;Yang et al, 2012), while other studies did not confirm this link (Ramlau-Hansen, Moeller, Bonde, Olsen, & Thulstrup, 2011;Zhu et al, 2016).…”

Section: Discussionmentioning

confidence: 99%

“…Some studies found a positive correlation with sperm motility and suggest that vitamin D increases sperm motility by increasing intracellular calcium levels and that it also has a regulatory role in testosterone synthesis (Jorde et al, 2013;Kinuta et al, 2000); there was no correlation between vitamin D, sperm motility and sex steroid hormones in the other studies (Blomberg & Dissing, 2012;Zhu et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

“…The enzymes necessitated in the metabolism of VDR and vitamin D have been found in male epididymis, seminal vesicle, prostate, germ and Leydig cells, and spermatozoa and have been reported to function in spermatogenesis, sperm maturation and sex hormone yield; in decreased fertility; and in vitamin D deficiency (Blomberg, ). Some studies found a positive correlation with sperm motility and suggest that vitamin D increases sperm motility by increasing intracellular calcium levels and that it also has a regulatory role in testosterone synthesis (Jorde et al, ; Kinuta et al, ); there was no correlation between vitamin D, sperm motility and sex steroid hormones in the other studies (Blomberg & Dissing, ; Inal, Erdem, et al, ; Zhu et al, ).…”

Section: Introductionmentioning

confidence: 99%

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Investigation of serum vitamin D and ischaemia‐modified albumin levels in infertile Turkish men

İnal¹,

İnal²,

Mermer³

et al. 2020

Andrologia

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Our aim was to explore the existence of a possible relationship of sperm motility with serum 25‐hydroxyvitamin D3 (25‐OH VD) levels and with ischaemia‐modified albumin (IMA) levels in infertile Turkish men. A total of 30 men with nonobstructive azoospermia (no spermatozoa in ejaculate), 30 men with oligospermia (total progressive motile sperm count (TPMSC) <15 × 106/ml) and 33 fertile men with normospermia (with at least one child, as the control group) were enrolled in the study. The mean 25‐OH VD levels for groups 1, 2 and 3 were 9.31 ± 6.46, 19.71 ± 12.80 and 30.52 ± 12.49 respectively (p < .05). There was a statistically significant difference in serum IMA levels among the groups (479.32 ± 307.56 vs. 296.37 ± 127.27 vs. 150.04 ± 81.05, respectively; p < .05). A positive correlation between serum 25‐OH VD levels and TPMSC, and a negative correlation between TPMSC and serum IMA levels were determined. Infertile men had lower serum 25‐OH VD and higher IMA levels than fertile men, with a positive correlation between serum 25‐OH VD levels and TPMSC, and a negative correlation between TPMSC and serum IMA levels. Vitamin D supplementation may increase the sperm motility.

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Section: Discussionmentioning

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Investigation of serum vitamin D and ischaemia‐modified albumin levels in infertile Turkish men

İnal¹,

İnal²,

Mermer³

et al. 2020

Andrologia

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show abstract

Vitamin D and chronic diseases: the current state of the art

et al. 2016

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The objective was to provide the current state of the art regarding the role of vitamin D in chronic diseases (osteoporosis, cancer, cardiovascular diseases, dementia, autism, type 1 and type 2 diabetes mellitus, male and female fertility). The document was drawn up by panelists that provided their contribution according to their own scientific expertise. Each scientific expert supplied a first draft manuscript on a specific aspect of the document's topic that was subjected to voting by all experts as "yes" (agreement with the content and/or wording) or "no" (disagreement). The adopted rule was that statements supported by ≥75 % of votes would be immediately accepted, while those with <25 % would be rejected outright. Others would be subjected to further discussion and subsequent voting, where ≥67 % support or, in an eventual third round, a majority of ≥50 % would be needed. This document finds that the current evidence support a role for vitamin D in bone health but not in other health conditions. However, subjects with vitamin D deficiency have been found to be at high risk of developing chronic diseases. Therefore, although at the present time there is not sufficient evidence to recommend vitamin D supplementation as treatment of chronic diseases, the treatment of vitamin D deficiency should be desiderable in order to reduce the risk of developing chronic diseases.

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The role of vitamin D in male fertility: A focus on the testis

Angelis¹,

Galdiero²,

Pivonello

et al. 2017

Rev Endocr Metab Disord

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In the last decade, vitamin D has emerged as a pleiotropic molecule with a multitude of autocrine, paracrine and endocrine functions, mediated by classical genomic as well as non-classical non-genomic actions, on multiple target organs and systems. The expression of vitamin D receptor and vitamin D metabolizing enzymes in male reproductive system, particularly in the testis, suggests the occurrence of vitamin D synthesis and regulation as well as function in the testis. The role of vitamin D in the modulation of testis functions, including hormone production and spermatogenesis, has been investigated in animals and humans. Experimental studies support a beneficial effect of vitamin D on male fertility, by modulating hormone production through genomic and non-genomic actions, and, particularly, by improving semen quality essentially through non-genomic actions. However, clinical studies in humans are controversial. Indeed, vitamin D seems to contribute to the modulation of the bioavailable rather than total testosterone. Moreover, although an increased prevalence or risk for testosterone deficiency was reported in men with vitamin D deficiency in observational studies, the majority of interventional studies demonstrated the lack of effect of vitamin D supplementation on circulating levels of testosterone. The most consistent effect of vitamin D was reported on semen quality. Indeed, vitamin D was shown to be positively associated to sperm motility, and to exert direct actions on spermatozoa, including non-genomic driven modulation of intracellular calcium homeostasis and activation of molecular pathways involved in sperm motility, capacitation and acrosome reaction. The current review provides a summary of current knowledge on the role of vitamin D in male fertility, by reporting clinical and experimental studies in humans and animals addressing the relationship between vitamin D and testis function.

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Investigation of serum vitamin D levels in Chinese infertile men

Cited by 36 publications

References 16 publications

Investigation of serum vitamin D and ischaemia‐modified albumin levels in infertile Turkish men

Investigation of serum vitamin D and ischaemia‐modified albumin levels in infertile Turkish men

Vitamin D and chronic diseases: the current state of the art

The role of vitamin D in male fertility: A focus on the testis

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