Investigation of shared genetic effects for psychotic and obsessive symptoms in young adult twins

Fagnani, Corrado; Tansella, Michele; Balestrieri, Matteo; Toccaceli, Virgilia; Patriarca, Valeria; Stazi, Maria Antonietta; Brambilla, Paolo

doi:10.1016/j.psychres.2010.12.002

Cited by 15 publications

(6 citation statements)

References 56 publications

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“…Another unanswered and important question pertains to the genetic and environmental influences of social mistrust. Twin studies of young adults in the general population have suggested moderate to high (about 50%) heritability estimates in paranoid ideation (Fagnani et al, 2011), with similar findings replicated in late adolescents (aged 16 years) (Shakoor et al, 2015a, 2015b, 2016). No sex difference in genetic and environmental influences on paranoia was evident (Shakoor et al, 2015a; Zavos et al, 2014).…”

Section: Introductionmentioning

confidence: 90%

Suspiciousness in young minds: Convergent evidence from non-clinical, clinical and community twin samples

Zhou

Wong

Shi

et al. 2018

Schizophrenia Research

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Section: Introductionmentioning

confidence: 90%

Suspiciousness in young minds: Convergent evidence from non-clinical, clinical and community twin samples

Zhou

Wong

Shi

et al. 2018

Schizophrenia Research

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“…This project is supported by a grant from the Italian Ministry of Health (Project title: 'SPES Service for detection of Pre-psychosES: from gene-environment interactions to phenomenology'). Within the same line of research, the relationships between psychotic and obsessive symptoms in young adult twins (Fagnani et al, 2011) and between magical ideation and personality in adult twins (Brambilla et al, 2014) were investigated. Within a collaboration with the Social and Cognitive Neuroscience Laboratory of the Sapienza University in Rome, whose main research interest is the neural representation of body image in healthy and brain-damaged patients, the ability of monozygotic (MZ) twins to distinguish their own face from the face of their co-twins was examined.…”

Section: From Children To Adults: Behavior Personality and Brain Funmentioning

confidence: 99%

The Italian Twin Registry: An Update at 18 Years From Its Inception

et al. 2019

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The Italian Twin Registry (ITR), established in 2001, is a population-based registry of voluntary twins. To date, it consists of approximately 29,000 twins who gave their consent to participate in the studies proposed by the ITR research group. The database comprises 11,500 monozygotic and 16,700 dizygotic twins resident throughout the country and belonging to a wide age range (from 0 to 95 years, mean 36.8 years). This article provides an overview of the recruitment strategies along with the major phenotypes investigated during an 18 years’ research period. Over the years, several self-reported questionnaire data were collected, together with saliva/blood samples and measurements taken during in-person interviews or outpatient clinical examinations. Mental and behavioral phenotypes as well as atherosclerotic traits were studied in depth across different age groups. A birth cohort of twins was established and followed up. Novel research hypotheses are also being tested in ongoing projects. The ITR is involved in international studies in collaboration with other twin registries and represents a valuable resource for national and international research initiatives regarding a broad spectrum of health-related characteristics.

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“…For details on the definition of each scale, please refer to a previous work of our group (2). Notably, twin studies reported that genetic factors have significant effects on temperament and on character dimensions, where the heritability does not show strong differences (3–5).…”

Section: Introductionmentioning

confidence: 99%

The Assertive Brain: Anterior Cingulate Phosphocreatine plus Creatine Levels Correlate With Self-Directedness in Healthy Adolescents

et al. 2019

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Despite various advances in the study of the neurobiological underpinnings of personality traits, the specific neural correlates associated with character and temperament traits are not yet fully understood. Therefore, this study aims to fill this gap by exploring the biochemical basis of personality, which is explored with the temperament and character inventory (TCI), during brain development in a sample of adolescents. Twenty-six healthy adolescents (aged between 13 and 21 years; 9 males and 18 females) with behavioral and emotional problems underwent a TCI evaluation and a 3T single-voxel proton magnetic resonance spectroscopy (1H MRS) acquisition of the anterior cingulate cortex (ACC). Absolute metabolite levels were estimated using LCModel: significant correlations between metabolite levels and selective TCI scales were identified. Specifically, phosphocreatine plus creatine (PCr+Cre) significantly correlated with self-directedness, positively, and with a self-transcendence (ST), negatively, while glycerophosphocholine plus phosphocholine (GPC+PC) and myo-inositol negatively correlated with ST. To the best of our knowledge, this is the first study reporting associations of brain metabolites with personality traits in adolescents. Therefore, our results represent a step forward for personality neuroscience within the study of biochemical systems and brain structures.

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Investigation of shared genetic effects for psychotic and obsessive symptoms in young adult twins

Cited by 15 publications

References 56 publications

Suspiciousness in young minds: Convergent evidence from non-clinical, clinical and community twin samples

Suspiciousness in young minds: Convergent evidence from non-clinical, clinical and community twin samples

The Italian Twin Registry: An Update at 18 Years From Its Inception

The Assertive Brain: Anterior Cingulate Phosphocreatine plus Creatine Levels Correlate With Self-Directedness in Healthy Adolescents

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