Investigation of silicon nanoparticles produced by centrifuge chemical vapor deposition for applications in therapy and diagnostics

Lumén, Dave; Wang, Shiqi; Mäkilä, Ermei; Imlimthan, Surachet; Sarparanta, Mirkka; Correia, Alexandra; Haug, Christina Westerveld; Hirvonen, Jouni; Santos, Hélder A.; Airaksinen, Anu J.; Filtvedt, W.O.; Salonen, Jarno

doi:10.1016/j.ejpb.2020.11.022

Cited by 16 publications

(5 citation statements)

References 39 publications

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“…The broad absorbance features of MPDA are also readily observed in MPDA–PsMME spectra [ 37 ]. As with the silica, the main absorbance bands of TCPSi, the Si–O and Si–C related vibrations near 1050–1100 cm −1 are highly visible in the TCPSi–PsMME nanoformulation [ 38 ].…”

Section: Resultsmentioning

confidence: 99%

Investigating the Effectiveness of Different Porous Nanoparticles as Drug Carriers for Retaining the Photostability of Pinosylvin Derivative

Howaili,

Saadabadi,

Mäkilä

et al. 2024

Pharmaceutics

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Pinosylvin monomethyl ether (PsMME) is a natural compound known for its valuable bioactive properties, including antioxidant and anti-inflammatory effects. However, PsMME’s susceptibility to photodegradation upon exposure to ultraviolet (UV) radiation poses a significant limitation to its applications in the pharmaceutical field. This study, for the first time, introduces a strategy to enhance the photostability of PsMME by employing various nanoformulations. We utilized mesoporous silica nanoparticles (MSNs) coated with polydopamine via a poly(ethylene imine) layer (PDA–PEI–MSNs), thermally carbonized porous silicon nanoparticles (TCPSi), and pure mesoporous polydopamine nanoparticles (MPDA). All these nanocarriers exhibit unique characteristics, including the potential for shielding the drug from UV light, which makes them promising for enhancing the photostability of loaded drugs. Here, these three nanoparticles were synthesized and their morphological and physicochemical properties, including size and ζ-potential, were characterized. They were subsequently loaded with PsMME, and the release profiles and kinetics of all three nanoformulations were determined. To assess their photoprotection ability, we employed gas chromatography with a flame ionization detector (GC-FID) and gas chromatography–mass spectrometry (GC-MS) to assess the recovery percentage of loaded PsMME before and after UV exposure for each nanoformulation. Our findings reveal that MPDA exhibits the highest protection ability, with a remarkable 90% protection against UV light on average. This positions MPDA as an ideal carrier for PsMME, and by extension, potentially for other photolabile drugs as well. As a final confirmation of its suitability as a drug nanocarrier, we conducted cytotoxicity evaluations of PsMME-loaded MPDA, demonstrating dose-dependent drug toxicity for this formulation.

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Section: Resultsmentioning

confidence: 99%

Investigating the Effectiveness of Different Porous Nanoparticles as Drug Carriers for Retaining the Photostability of Pinosylvin Derivative

Howaili,

Saadabadi,

Mäkilä

et al. 2024

Pharmaceutics

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Section: Discussionmentioning

confidence: 99%

“…5 Varying toxicity for different surface modifications of porous silicon materials has been documented. 20,44,45 Furthermore, depending on the administration route, extensive in vivo studies and clinical trials of an eventual final nanomedicine product are needed to guarantee clinical safety. 46 The release rate of drugs from nanocarriers depends on several factors including the degradation rate of the carrier material, the surface area available for adsorption and dissolution, the drug solubility and the hydrophilic-lipophilic, electrostatic, or other interactions between the drug and carrier.…”

Section: Drug Deliverymentioning

confidence: 99%

“…The method yielded Si particles that have the ability to produce therapeutic levels of hydrogen gas 19 and have shown promising biocompatibility measures. 20 The cCVD process allows control over synthesis parameters such as temperature and growth time to regulate particle properties like primary and total particle size. 21,22 A means to achieve porous particles by controlled aggregation of small primary particles into larger "snow lantern-like" particles using the cCVD process, and its potential as a drug delivery material, is documented in the present study.…”

Section: Introductionmentioning

confidence: 99%

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Stable “snow lantern-like” aggregates of silicon nanoparticles suitable as a drug delivery platform

Johnsen,

Hossaini Nasr,

De Luna

et al. 2024

Nanoscale

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“…Many techniques have been used for the fabrication of Si NCs, the chemical vapor deposition (CVD), the annealing of Si rich oxide (SRO) layers or the implantation of Si in SiO2 layers. However, these techniques commonly produce NCs with crystalline defects and/or impurities (specially at the NCs/SiO2 interface), inhomogeneous size, low densities and imprecise positioning [15][16][17][18][19][20] which make them unsuitable for optoelectronic applications.…”

Section: Introductionmentioning

confidence: 99%

High-sensitive MIS structures with silicon nanocrystals grown via solid-state dewetting of silicon-on-insulator for solar cell and photodetector applications

Aouassa

Algarni

Althobaiti

et al. 2022

J Mater Sci: Mater Electron

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This work reports an original method for the fabrication of Metal-Isulator-Semiconductor (MIS) structures with silicon nanocrystals (Si NCs) based active layers embedded in the insulating SiO2 oxide, for high performance solar cell and photodetector applications. The Si NCs are produced via the in situ solid-state dewetting of ultra-pure amorphous silicon-oninsulator (a-SOI) grown by solid source molecular beam epitaxy (SSMBE). The size and density of Si NCs are precisely tuned by varying the deposited thickness of silicon. The morphological characterization carried out by using atomic force microscopy (AFM) and scanning electron microscopy (SEM) shows that the Si NCs have homogeneous size with welldefined spherical shape and densities up to ~10 12 /cm 2 (inversely proportional to the square of nominal a-Si thickness). The structural investigations by high resolution transmission electron microscopy (HR-TEM) show that the ultra-small Si NCs (with mean diameter ~7 nm) are monocrystalline and free of structural defects. The electrical measurements performed by current versus voltage (I-V) and photocurrent spectroscopies on the Si-NCs based MIS structures prove the efficiency of Si NCs to enhance the electrical conduction in MIS structures and to increase (x10 times) the photocurrent (i.e. at bias voltage V = -1 V) via the photogeneration of additional electron-hole pairs in the MIS structures. These results evidence that the Si NCs obtained by the combination of MBE growth and solid-state dewetting are perfectly suitable for the development of novel high performance optoelectronic devices compatible with the CMOS technology.

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Investigation of silicon nanoparticles produced by centrifuge chemical vapor deposition for applications in therapy and diagnostics

Cited by 16 publications

References 39 publications

Investigating the Effectiveness of Different Porous Nanoparticles as Drug Carriers for Retaining the Photostability of Pinosylvin Derivative

Investigating the Effectiveness of Different Porous Nanoparticles as Drug Carriers for Retaining the Photostability of Pinosylvin Derivative

Stable “snow lantern-like” aggregates of silicon nanoparticles suitable as a drug delivery platform

High-sensitive MIS structures with silicon nanocrystals grown via solid-state dewetting of silicon-on-insulator for solar cell and photodetector applications

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