Investigation of Some Crown Ether Compounds for Electrochemical Determination of Dopamine

Abstract

In this study, the use of three different crown ether-modified electrodes prepared by electropolymerization of different crown ether compounds (CE1, CE2 and CE3) on multi-walled carbon nanotube (MWCNT) modified glassy carbon electrode (GCE) surfaces was investigated for electrochemical dopamine determination. The number of cycles during the electropolymerization of crown ethers and the pH of the buffer solution were optimized. Under optimum conditions, the sensitivities of MWCNT-modified GCE and crown ether-MWCNT-modified electrodes were determined in the range of 4.0×10-6 – 5.7×10-4 M dopamine. The sensitivity of MWCNT/GCE was found to be 6.71 µA mM-1, while the sensitivities of CE1/MWCNT/GCE, CE2/MWCNT/GCE and CE3/MWCNT/GCE were 19.53, 16.32 and 20.80 µA mM-1, respectively. The performance characteristics of the crown ether-MWCNT-modified electrodes such as detection limit, quantification limit, reusability and reproducibility were also investigated. The study showed that crown ether compounds significantly enhanced the electrochemical response in dopamine determination.