This study aimed to evaluate the clinical utility of a nursing intervention program to promote cancer pain self-management for outpatients by adapting the program for clinical practice.Methods: This study used a single-group, pre-post intervention comparative research design. In the study, a face-to-face individual intervention using the program was conducted three times for 10 outpatients with cancer pain. A self-administered questionnaire survey was conducted, and the scores of pain intensity, interference with daily life, quality of life, self-Efficacy, anxiety and depression were compared and analyzed before and after the intervention.Results: The mean participant age was 59.9 (SD 8.3) years. The items that had a large effect size comparing those before and after the intervention were anxiety (r = .63) and depression (r = .67), which decreased significantly (p < .05). The items that were not significantly different but had a medium effect size were the most severe pain (r = .36), average pain (r = .33), and total interference with daily life (r = .31), which both decreased after the intervention. The satisfaction with the analgesic treatment (r = .36) increased after the intervention.Conclusion: Patient anxiety and depression decreased significantly, and pain intensity, interference with daily life and satisfaction with analgesic treatment had a medium positive effect size. Overall, this program was suggested to have clinical utility.