Investigation of speckle contrast ratio in optical coherence tomography

Adie, Steven G.; Hillman, Timothy R.; Sampson, David D.

doi:10.1117/12.645700

Cited by 1 publication

(2 citation statements)

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“…where H 2d denotes the one-dimensional Hilbert transform operator applied along each scan of the OCT image [8]. The Hilbert-transformed series has the same amplitude and frequency content as the original real data and includes phase information that depends on the phase of the original data.…”

Section: Am-fm Analysismentioning

confidence: 99%

“…However, it has recently been recognized that speckle contains information regarding such unresolvable features. Studies have shown that the contrast ratio and size of speckle, in the demodulated (amplitude) OCT image, can be used as a measure of scatterer properties [7,8]. In addition, it is also well known that changes in scatterer size induce changes in the spectral content of scattered light [9].…”

Section: Biophotonicsmentioning

confidence: 99%

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AM–FM techniques in the analysis of optical coherence tomography signals

Pitris

Kartakoullis

Bousi

2009

Journal of Biophotonics

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The subtle tissue changes associated with the early stages of malignancies, such as cancer, are not clearly discernible even at the current, improved, resolution of optical coherence tomography (OCT) systems. However, these changes directly affect the spectral content of the OCT image that contains information regarding these unresolvable features. Spectral analysis of OCT signals has recently been shown to provide additional information, resulting in improved contrast, directly related to scatterer size changes. Amplitude modulation-frequency modulation (AM-FM) analysis, a fast and accurate technique for the estimation of the instantaneous frequency, phase, and amplitude of a signal, can also be applied to OCT images to extract scatterer-size information. The proposed technique could make available an extremely valuable tool for the investigation of disease characteristics that now remain below the resolution of OCT and could significantly improve the technology's diagnostic capabilities.

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Section: Am-fm Analysismentioning

confidence: 99%

Section: Biophotonicsmentioning

confidence: 99%