Investigation of strontium accumulation on ovariectomized Sprague–Dawley rat tibia by micro-PIXE

Li, X.; Li, Y.; Wei-fang, Jin; Zheng, Yi; Rong, Chun; Lyu, Houchen; Shen, H. F.

doi:10.1016/j.nimb.2014.02.087

Cited by 5 publications

(3 citation statements)

References 57 publications

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“…It is evident that the implant surface plays a key role when biomedical materials/devices respond to the physiological environment. [33][34][35] Therefore, our interest was aroused and we were inspired to design this study due to the possibility of the Sr element stimulating osteogenesis as well as the possibility that the micro/nano surface improving cell-material interactions could have a synergistic effect on promoting osseointegration and bioactivity. 21 From the perspective of bionics, cell functions would be positively enhanced by constructing a hierarchical structure containing micro-and nanosized parts on implant surfaces to better mimic the architecture of the natural extracellular matrix.…”

Section: Introductionmentioning

confidence: 99%

“…[29][30][31][32] However, to our knowledge, it is rare to use Sr-substituted implants together with micro/nanotopography to investigate the bone formation and osseointegration in osteoporotic bones in current research, though there have been some previous studies of Sr-doped implants in vivo. [33][34][35] Therefore, our interest was aroused and we were inspired to design this study due to the possibility of the Sr element stimulating osteogenesis as well as the possibility that the micro/nano surface improving cell-material interactions could have a synergistic effect on promoting osseointegration and bioactivity.…”

Section: Introductionmentioning

confidence: 99%

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Strontium delivery on topographical titanium to enhance bioactivity and osseointegration in osteoporotic rats

Wen

Pan

et al. 2015

J. Mater. Chem. B

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Strontium delivery on topographical titanium to enhance bioactivity and osseointegration in osteoporotic ratsThis work completed by Wen Jin, Li Jinhua et al. indicated that a topographical titanium surface with substituted strontium could promote osteogenic diff erentiation, inhibit osteoclast formation in vitro and have a good osseointegration eff ect in osteoporotic rats. 4790 | J. Mater. Chem. B, 2015, 3, 4790--4804 This journal is Osseointegration remains a major clinical challenge in osteoporotic patients. Strontium (Sr) has been shown to be a significant therapy to favor bone growth by both increasing new bone formation and reducing bone resorption. In this study, we attempt to chemically functionalize Ti implants by micro-arc oxidation, alkali treatment and ion exchange. This functionalized Ti surface possessed a hierarchical topography with Sr incorporation, which can release Sr ions at a slow rate. To our knowledge, this work is the first to use this type of Sr-doped Ti surface to address osteoporotic bone mesenchymal stem cells (BMSCs) in the dual directions of bone regeneration, bone formation and bone resorption. The modified surface was demonstrated to remarkably enhance the adhesion, spreading, and osteogenic differentiation of BMSCs in vitro. The effect of the wash-out solution from various groups on osteoporotic BMSCs was also investigated. The Sr-doped group can improve the ALP activity and osteogenic gene expression.Moreover, the Sr-doped group and the wash-out solution show the most inhibition in osteoclast formation and maturation. Furthermore, the increased bioactivity of the hierarchical structure was also confirmed with the ovariectomized rat femur model in vivo. The outcome of fluorescence labeling, histology and histomorphometric analysis demonstrated a significant promotion of osseointegration in ovariectomized rats. Altogether, the experimental data indicate that the fabrication of a Sr-doped hierarchical Ti surface is a meaningful attempt to incorporate the Sr nutrient element into Ti-based implants, and it is expected to be exploited in developing better osseointegration for osteoporotic patients.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Strontium delivery on topographical titanium to enhance bioactivity and osseointegration in osteoporotic rats

Wen

Pan

et al. 2015

J. Mater. Chem. B

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“…The need to prevent bone fractures has led to the therapeutic use of bone seeking elements that can substitute for calcium in the hydroxyapatite of the bone. Strontium has been shown to possess strong bone seeking properties (Li et al, 2014). Many bene cial e ects may be achieved at low doses, however, toxic effects at higher levels such as: enamel mottling may arise, rickets and osteomalacia; the proper amount of elemental strontium to be administered is crucial (Curzon and Spector, 1977).…”

Section: Strontium-based Treatment For Osteoporosismentioning

confidence: 99%

Elemental Mapping of Bone Strontium in Rats Treated with Strontium Ranelate and Strontium Citrate Using 2D Micro-XRF and 3D Dual Energy K-Edge Subtraction X-ray Imaging

Cardenas¹

2023

Preprint

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Strontium-based medications, such as strontium ranelate, have been shown to have therapeutic effects in the treatment of osteoporosis, other strontium salts are assumed to have similar effects on bone health. The objective of this study was to compare the distribution of strontium in animal bones following administration of strontium ranelate and strontium citrate. Humerus bones were collected from female Sprague-Dawley rats that were dosed daily over ten weeks with strontium ranelate and strontium citrate, and no strontium (control). Bones were imaged using 2D micro-XRF and 3D dual energy KES X-ray imaging. The 2D imaging revealed differences in strontium and calcium levels between samples from treated and non-treated animals (푝 < 0.001). 3D images obtained showed that strontium was observed to be largely present in the trabecular regions under the epiphyseal plate with concentrations of approximately 5 to 15 mg/cm3 in the bones of both strontium treated groups. The thickness of the strontium layers below the growth plate in both the strontium ranelate and strontium citrate sample were not significantly different (푝 = 0.9201). Both imaging studies performed in this work showed that strontium from both salts is heterogeneously distributed in newly formed bone during treatment.

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Reconstruction of Ge spatial distribution in ICF target using PIXE-T

Lü

Meng

et al. 2016

Fusion Engineering and Design

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Investigation of strontium accumulation on ovariectomized Sprague–Dawley rat tibia by micro-PIXE

Cited by 5 publications

References 57 publications

Strontium delivery on topographical titanium to enhance bioactivity and osseointegration in osteoporotic rats

Strontium delivery on topographical titanium to enhance bioactivity and osseointegration in osteoporotic rats

Elemental Mapping of Bone Strontium in Rats Treated with Strontium Ranelate and Strontium Citrate Using 2D Micro-XRF and 3D Dual Energy K-Edge Subtraction X-ray Imaging

Reconstruction of Ge spatial distribution in ICF target using PIXE-T

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