Investigation of suitable starting doses of narrowband UVB in Asian vitiligo patients: a pilot study

Lee, H.; Chu, Howard; Oh, Sang Ho

doi:10.1111/jdv.13933

Cited by 2 publications

(1 citation statement)

References 18 publications

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“…Related studies on these diseases all suggested that the anti-inflammation effect of ADSCs occurs via the IL-1β pathway. Previous studies have shown that ADSCs affect the treatment of scars induced by P. acnes [ 44 ] and diabetic wound healing [ 45 – 47 ]. ADSCs have the advantage of being abundant, easy to obtain, and usable without ethical constraints.…”

Section: Discussionmentioning

confidence: 99%

Adipose-derived stem cells attenuate acne-related inflammation via suppression of NLRP3 inflammasome

Luo

Chen

et al. 2022

Stem Cell Res Ther

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Background Acne is a chronic facial disease caused by Propionibacterium acnes, which proliferates within sebum-blocked skin follicles and increases inflammatory cytokine production. Several therapeutic drugs and products have been proposed to treat acne, yet no single treatment that ensures long-term treatment efficacy for all patients is available. Here, we explored the use of facial autologous fat transplant of adipose-derived stem cells (ADSCs) to dramatically reduce acne lesions. Methods THP-1 cells were treated with active P. acnes for 24 h at different multiplicities of infection, and alterations in inflammatory factors were detected. To study the effect of THP-1 on inflammasome-related proteins, we first co-cultured ADSCs with THP-1 cells treated with P. acnes and evaluated the levels of these proteins in the supernatant. Further, an acne mouse model injected with ADSCs was used to assess inflammatory changes. Results Propionibacterium acnes-mediated stimulation of THP-1 cells had a direct correlation with the expression of active caspase-1 and interleukin (IL)-1β in an infection-dependent manner. ADSCs significantly reduced the production of IL-1β induced by P. acnes stimulation through the reactive oxygen species (ROS)/Nod-like receptor family pyrin domain-containing 3 (NLRP3)/caspase-1 pathway. The results showed that ADSCs inhibit the skin inflammation induced by P. acnes by blocking the NLRP3 inflammasome via reducing the secretion of IL-1β in vivo. Conclusions Our findings suggest that ADSCs can alter IL-1β secretion by restricting the production of mitochondria ROS, thereby inhibiting the NLRP3/caspase-1 pathway in P. acnes-induced inflammatory responses. This study indicates that anti‐acne therapy can potentially be developed by targeting the NLRP3 inflammasome.

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Section: Discussionmentioning

confidence: 99%

Adipose-derived stem cells attenuate acne-related inflammation via suppression of NLRP3 inflammasome

Luo

Chen

et al. 2022

Stem Cell Res Ther

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Identification of factors associated with minimal erythema dose variations in a large‐scale population study of 22 146 subjects

Tan

Wang

Fan

et al. 2020

Acad Dermatol Venereol

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Background Minimal erythema dose (MED) has substantial inter‐ and intraindividual variations, reflecting the influence of very diverse factors. However, related studies showed little consistency probably because of their limited sample size. Objective To identify the factors associated with MED variations in a large‐scale population study. Methods The MED test was performed by following the international standard procedure on 22 146 subjects. The results were analysed in adjusted multivariable linear and logistic regression models. Results This large‐scale study revealed that lower MED was consistently associated with lighter skin [β‐coefficient = −0.33, 95% confidence interval ( CI ) −0.36 to 0.30, P = 6.41 × 10 −84 ]. Females had significantly higher MED than male (β = 0.91, 0.32–1.50, P = 2.93 × 10 −3 ). Stratified analyses showed that MED was not associated with age [female: odds ratio ( OR ) = 0.99, 0.98–1.01; male: OR = 0.99, 0.97–1.00]. MED was lower in summer than in other seasons (spring: OR = 1.08, 1.06–1.11; autumn: OR = 1.11, 1.08–1.13; winter: OR = 1.20, 1.18–1.22). Furthermore, MED was associated with air temperature (β = −0.36, −0.49 to 0.23, P = 4.81 × 10 −8 ) and air pressure (β = −0.64, −0.82 to 0.46, P = 8.01 × 10 −12 ) in summer only while not in other seasons. Conclusions This study provides unprecedented evidence that MED is associated with skin colour, sex, season and meteorological factors, but not with age.

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Investigation of suitable starting doses of narrowband UVB in Asian vitiligo patients: a pilot study

Abstract: Results from phototest and tolerability of patients to doses higher than 280 mJ/cm may indicate that higher starting doses might be appropriate for Asian vitiligo patients.

Cited by 2 publications

References 18 publications

Adipose-derived stem cells attenuate acne-related inflammation via suppression of NLRP3 inflammasome

Adipose-derived stem cells attenuate acne-related inflammation via suppression of NLRP3 inflammasome

Identification of factors associated with minimal erythema dose variations in a large‐scale population study of 22 146 subjects

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